Response Functions For Nontraditional Inputs In Agriculture

As part of the restructured regional research program of the U.S. Department of Agriculture and the Land-Grant Universities, a research strategy committee (NCR-113) was formed in 1978 to identify new research tHrusts in the area of farm firm management-and finance. At the .first meeting in April, 1979, a number of possible areas for additional research activity or new thrusts were identified. One area identified was that of the development and utilization of new inputs in agri culture and the estimation of response functions for these inputs..

Near wake of a hypersonic blunt body with mass addition

An experimental investigation of the steady, laminar near-wake flowfield of a two-dimensional, adiabatic, circular cylinder ·with surface mass transfer has been made at a freestream Mach number of 6.0. The pressure and mass- concentration fields associated with the transfer of argon, nitrogen, or helium into the near wake were studied for mass transfer from the forward stagnation region, and from the base. For sufficiently low mass transfer rates from the base, for which a recirculating zone exists, the entire near-wake flowfield correlates with the momentum flux, not the mass flux, of the injectant, and the mass-concentration field is determined by counter-current diffusion into the reversed flow. For mass addition from the forward stagnation region, the pressure field is undisturbed and the mass- concentration field is nearly uniform in the region of reversed flow. The axial decay of argon mass concentration in the intermediate wake, downstream of the neck, is explained with the aid of an integral solution in the incompressible plane, from which the location of the virtual origin for the asymptotic far-wake solution has been derived as one result

The first confirmed superoutburst of the SU UMa type dwarf nova SDSS J083931.35+282824.0

We report unfiltered CCD photometry of the first confirmed superoutburst of the recently discovered dwarf nova, SDSS J083931.35+282824.0 in April 2010. From a quiescence magnitude of ~19.8 it rose to 14.0, an outburst amplitude of at least 5.8 magnitudes. Only the plateau phase of the outburst was observed during which superhumps with peak-to-peak amplitude of up to 0.28 magnitudes were present, confirming this to be an SU UMa type dwarf nova. The mean superhump period was Psh = 0.07836(2) during the first 3 days and this subsequently decreased to 0.07800(3) d. Analysis of the data revealed tentative evidence for an orbital period Porb = 0.07531(25) d. The fractional superhump period excess was epsilon = 0.039(6), which is consistent with other dwarf novae of similar orbital period.Comment: 12 pages, 3 figures. Accepted for publication in the Journal of the British Astronomical Associatio

Deletion of the trpc4 gene and its role in simple and complex strategic learning

The TRPC4 ion channel is expressed extensively in corticolimbic and a subpopulation of midbrain dopamine neurons. While TRPC4 knockout (KO) rats exhibit reduced sociability and social exploration, little is known about the role of TRPC4 in motivation and learning. To identify a function for TRPC4 channels in learning processes  we tested TRPC4 KO and normal wild type (WT) rats. TRPC4 KO and WT rats exhibited no differences in Y-­maze learning or simple discrimination learning. Furthermore, on a more complex serial reversal shift task designed  to assess strategic learning where the reward and non-­reward cues were repeatedly reversed between training sessions both TRPC4 KO and WT rats   performed equally well. Finally, we found no   performance differences when using a conditional reversal shift task where a tone signals the reversal of reward and non-reward cues within sessions. These data suggest that although TRPC4 channels may play a role in social interaction/anxiety  they exert a minimal role in simple and complex strategic learning

ρ\rho and K∗K^* resonances on the lattice at nearly physical quark masses and Nf=2N_f=2

Working with a pion mass $m_\pi \approx 150$ MeV, we study $\pi\pi$ and $K\pi$ scattering using two flavours of non-perturbatively improved Wilson fermions at a lattice spacing $a\approx 0.071$ fm. Employing two lattice volumes with linear spatial extents of $N_s=48$ and $N_s=64$ points and moving frames, we extract the phase shifts for p-wave $\pi\pi$ and $K\pi$ scattering near the $\rho$ and $K^*$ resonances.Comparing our results to those of previous lattice studies, that used pion masses ranging from about 200 MeV up to 470 MeV, we find that the coupling $g_{\rho\pi\pi}$ appears to be remarkably constant as a function of $m_{\pi}$.Comment: 16 pages, 8 figures, v2: "and $N_f=2$" added to the title, references updated, some figures replaced, including improved summary plots, alternative parametrizations are considered and analytical continations are performed to determine pole positions on the second Riemann shee

Frio pilot in CO2 sequestration in brine-bearing sandstones: The University of Texas at Austin, Bureau of Economic Geology, report to the Texas Commission on Environmental Quality to accompany a class V application for an experimental technology pilot injection well.

GEOSEQ project (LBNL, LLNL, ORNL), NETL, Schlumberger–Doll Research Center, Transpetco, Sandia TechnologiesJackson School of Geoscience

Equalization in redundant channels

A miscomparison between a channel's configuration data base and a voted system configuration data base in a redundant channel system having identically operating, frame synchronous channels triggers autoequalization of the channel's historical signal data bases in a hierarchical, chronological manner with that of a correctly operating channel. After equalization, symmetrization of the channel's configuration data base with that of the system permits upgrading of the previously degraded channel to full redundancy. An externally provided equalization command, e.g., manually actuated, can also trigger equalization

Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

With advances in screening, the incidence of detection of premalignant breast lesions has increased in recent decades; however, treatment options remain limited to surveillance or surgical removal by lumpectomy or mastectomy. We hypothesized that disease progression could be blocked by RNA interference (RNAi) therapy and set out to develop a targeted therapeutic delivery strategy. Using computational gene network modeling, we identified HoxA1 as a putative driver of early mammary cancer progression in transgenic C3(1)-SV40TAg mice. Silencing this gene in cultured mouse or human mammary tumor spheroids resulted in increased acinar lumen formation, reduced tumor cell proliferation, and restoration of normal epithelial polarization. When the HoxA1 gene was silenced in vivo via intraductal delivery of nanoparticle-formulated small interfering RNA (siRNA) through the nipple of transgenic mice with early-stage disease, mammary epithelial cell proliferation rates were suppressed, loss of estrogen and progesterone receptor expression was prevented, and tumor incidence was reduced by 75%. This approach that leverages new advances in systems biology and nanotechnology offers a novel noninvasive strategy to block breast cancer progression through targeted silencing of critical genes directly within the mammary epithelium.Engineering and Applied Science

Relating hygroscopicity and composition of organic aerosol particulate matter

A hygroscopicity tandem differential mobility analyzer (HTDMA) was used to measure the water uptake (hygroscopicity) of secondary organic aerosol (SOA) formed during the chemical and photochemical oxidation of several organic precursors in a smog chamber. Electron ionization mass spectra of the non-refractory submicron aerosol were simultaneously determined with an aerosol mass spectrometer (AMS), and correlations between the two different signals were investigated. SOA hygroscopicity was found to strongly correlate with the relative abundance of the ion signal m/z 44 expressed as a fraction of total organic signal (f44). m/z 44 is due mostly to the ion fragment CO2+ for all types of SOA systems studied, and has been previously shown to strongly correlate with organic O/C for ambient and chamber OA. The analysis was also performed on ambient OA from two field experiments at the remote site Jungfraujoch, and the megacity Mexico City, where similar results were found. A simple empirical linear relation between the hygroscopicity of OA at subsaturated RH, as given by the hygroscopic growth factor (GF) or "ϰorg" parameter, and f44 was determined and is given by ϰorg = 2.2 × f44 − 0.13. This approximation can be further verified and refined as the database for AMS and HTDMA measurements is constantly being expanded around the world. The use of this approximation could introduce an important simplification in the parameterization of hygroscopicity of OA in atmospheric models, since f44 is correlated with the photochemical age of an air mass

Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum.

Malaria is caused by an obligate intracellular protozoan parasite that replicates within and destroys erythrocytes. Asexual blood stages of the causative agent of the most virulent form of human malaria, Plasmodium falciparum, can be cultivated indefinitely in vitro in human erythrocytes, facilitating experimental analysis of parasite cell biology, biochemistry and genetics. However, efforts to improve understanding of the basic biology of this important pathogen and to develop urgently required new antimalarial drugs and vaccines, suffer from a paucity of basic research tools. This includes a simple means of quantifying the effects of drugs, antibodies and gene modifications on parasite fitness and replication rates. Here we describe the development and validation of an extremely simple, robust plaque assay that can be used to visualise parasite replication and resulting host erythrocyte destruction at the level of clonal parasite populations. We demonstrate applications of the plaque assay by using it for the phenotypic characterisation of two P. falciparum conditional mutants displaying reduced fitness in vitro