828 research outputs found
Louvain-Based Fusion of Topology and Attribute Structure of Social Networks
With the increasing diversity and complexity of online social networks, effectively dividing communities presents a growing challenge. These networks are characterized by their large scale, sparse structure, and numerous isolated points. Traditional community detection methods lack consideration of node attribute information, thereby negatively impacting the accuracy of community detection. To address these challenges, this paper presents a novel Louvain-FTAS community detection algorithm that integrates topology and attribute structure. The proposed algorithm first selects attributes with positive effects to account for attribute heterogeneity. Subsequently, it utilizes a semi-local strategy to calculate topology similarity and information entropy to calculate attribute similarity. These values are combined to obtain the final node similarity matrix, which is then fed into the Louvain algorithm to maximize modularity and incorporate multi-dimensional attribute features to enhance community detection accuracy. The proposed model is evaluated through comparative experiments on two real datasets and artificial synthetic networks, demonstrating its rationality and effectiveness
Chronic Glucocorticoid Exposure Induces Depression-Like Phenotype in Rhesus Macaque (Macaca Mulatta)
It has long been observed in humans that the occurrence of depressive symptoms is often accompanied by the dysfunction of hypothalamic-pituitary-adrenal (HPA) axis. The rodent experiments also showed that chronic corticosterone exposure could induce depression-like phenotype. However, rodents are phylogenetically distant from humans. In contrast, non-human primates bear stronger similarities with humans, suggesting research on primates would provide an important complement. For the first time, we investigated the effects of chronic glucocorticoid exposure on rhesus macaques. Seven male macaques were selected and randomized to glucocorticoid or vehicle groups, which were subjected to either prednisolone acetate or saline injections, respectively. The depression-like behaviors were assessed weekly, and the body weights, HPA axis reactivity, sucrose solution consumption and monoaminergic neurotransmitters were further compared between these two groups. The glucocorticoid group was not found to display more depression-like behaviors than the vehicle group until 7 weeks after treatment. Chronic glucocorticoid exposure significantly decreased the levels of cortisol determined from blood (a biomarker for acute HPA axis reactivity) but increased the hair cortisol concentrations (a reliable indicator of chronic HPA axis reactivity) compared with controls. The glucocorticoid group was also found to consume less sucrose solution than controls, a good manifestation of anhedonia. This could be possibly explained by lower dopamine (DA) levels in cerebrospinal fluid induced by chronic glucocorticoid treatment. The results presented here indicate that chronic glucocorticoid exposure could disturb both the acute and chronic HPA axis reactivity, which eventually disturbed the neurotransmitter system and led monkeys to display depression-like phenotype
A conceptual framework for after-sales service risk reduction of Chinese agricultural machinery in South Africa
After-sales service (ASS) plays a significant role following the agricultural machinery
being sold. With the development of trade and economic exchange between South Africa and
China. Chinese agricultural machinery has increasingly sold to South African and Africa. After-
sales service becomes crucial important to maintenance the machinery. Results found that the
people whose age was between 30 and 49 that much involved in the research findings.
Comparison between South African and China found to be more males participate (79.2%) in
China, and more females (29.2%) in South Africa. It found that South African female engaged
more than Chinese females. The staff and directors made up the majority of participants, where
staff and directors accounted for 54.2% in South Africa and 70.9% from China’s side. The
percentage on the degree of high school level of Chinese interviewees showed the highest
among these five items, which were 50% compared to the highest degree of South African
participants at the college level (37.5%). There was no interviewer who earned a major in
engineering in South African involved in this study and there was an endeavor to employ more
engineers in South Africa. The highest point was the value of spare parts factor from the
perspective of South African participants, followed by the factors repairing, maintenance,
technician and training. The focus group was concerned with the other factors that impacted on
the ASS of AM. The focus-group in China showed that except for the factors that influenced
the ASS of AM, Sanbao; three Guarantees: repair, replacement and return, and customer’s
satisfaction played a significant role in the process of ASS of AM. With this, the factors
included the revisiting, maintenance, technology assistance, tracking service and customer’s
satisfaction. The focus-group in South Africa found that after-sales service was faced a crucial
effect to ASS of AM.http://www.ijat-aatsea.comhj2023Graduate School of Technology Management (GSTM
A fast responsive chromogenic and near-infrared fluorescence lighting-up probe for visual detection of toxic thiophenol in environmental water and living cells
Thiophenols as high toxic environmental pollutants are poisonous for animals and aquatic organisms. Therefore,
it is indispensable to monitor thiophenols in the environment. Herein, a novel near-infrared fluorescent probe
was developed for the detection of thiophenols, which was easily prepared by one-step coupling of 2,4-dini trobenzenesulfonyl chloride with Nile blue. The probe showed a significant near infrared (∼675 nm) fluores cence “turn-on” response to thiophenols with some good features including chromogenic reaction, high sensi tivity and selectivity, fast response, near-infrared emission along with low detection limit (1.8 nM). The probe
was employed to rapidly and visually determine thiophenols in several industrial wastewaters with good re coveries (90–110%). Moreover, this probe has been demonstrated good capability for imaging thiophenol in
HeLa cellsinfo:eu-repo/semantics/publishedVersio
Editorial: Processes, mechanisms and solutions in coastal wetland to adapt to changing environment
Semi-classical solutions of perturbed elliptic system with general superlinear nonlinearity
Abstract
This paper is concerned with the following perturbed elliptic system:
−
ε
2
△
u
+
V
(
x
)
u
=
W
v
(
x
,
u
,
v
)
,
x
∈
R
N
,
−
ε
2
△
v
+
V
(
x
)
v
=
W
u
(
x
,
u
,
v
)
,
x
∈
R
N
,
u
,
v
∈
H
1
(
R
N
)
, where
V
∈
C
(
R
N
,
R
)
and
W
∈
C
1
(
R
N
×
R
2
,
R
)
. Under some mild conditions on the potential V and nonlinearity W, we establish the existence of nontrivial semi-classical solutions via variational methods, provided that
0
<
ε
≤
ε
0
, where the bound
ε
0
is formulated in terms of N, V, and W.
MSC: 35J10, 35J20.</jats:p
Rheumatoid arthritis-associated depression: focusing on the interactions between mitochondria and endoplasmic reticulum
The interplay between mitochondria and endoplasmic reticulum (ER) is essential for cellular viability. The structures known as mitochondria-associated endoplasmic reticulum membranes (MAM) provide complicated connections between these organelles, which house a variety of proteins, each serving distinct roles across different cellular environments. Growing evidence indicates that disruptions in mitochondrial-ER interactions are linked to immune and inflammatory responses. The concurrent presence of rheumatoid arthritis (RA), an immune-mediated inflammatory condition, and depression has been well-documented. Alterations in proteins that mediate mitochondrial-ER interactions and MAM functionality are increasingly correlated with immune and inflammatory pathways. This suggests that a comprehensive understanding of disease mechanisms can be enhanced by examining the alterations in their intercommunication rather than viewing the organelles in isolation. In this review, we explore the pathophysiological mechanisms underlying RA in conjunction with depression, the relationships among mitochondria, the endoplasmic reticulum, mitochondrial-ER interactions, and their association with RA-associated depression, and propose that targeting MAM could offer a novel therapeutic approach for managing RA-associated depression
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