Observations of tetrel bonding between sp3-carbon and THF

We report the direct observation of tetrel bonding interactions between sp3-carbons of the supramolecular synthon 3,3-dimethyl-tetracyanocyclopropane (1) and tetrahydrofuran in the gas and crystalline phase. The intermolecular contact is established via σ-holes and is driven mainly by electrostatic forces. The complex manifests distinct binding geometries when captured in the crystalline phase and in the gas phase. We elucidate these binding trends using complementary gas phase quantum chemical calculations and find a total binding energy of −11.2 kcal mol−1 for the adduct. Our observations pave the way for novel strategies to engineer sp3-C centred non-covalent bonding schemes for supramolecular chemistry

Evaluation of functional capacity by spiroergometry before and after pulmonary thromboendarterectomy

In der vorliegenden Dissertation wurde die funktionelle Kapazität bei 61 Patienten mit CTEPH mit Hilfe der Spiroergometrie im zeitlichen Verlauf vor und nach pulmonaler Thrombendarteriektomie evaluiert. Hierbei konnte frühzeitig postoperativ eine signifikante Verbesserung der Atemeffizienz und der Gasaustauschstörung nachgewiesen werden. Im späteren postoperativen Verlauf konnte eine weitere Verbesserung der Sauerstoffaufnahme und der Atemeffizienz bei Belastung aufgrund eines Trainingseffektes gezeigt werden. Die hier vorgelegte Arbeit hat im Vergleich zu vorausgehend publizierten Untersuchungen wesentlich mehr spiroergometrische Parameter untersucht und damit einen weitergehenden Beitrag zum Verständnis kardiopulmonaler Effekte der pulmonalen Thrombendarteriektomie geliefert. Letztlich ist unserer Auffassung nach unter Hinzunahme der aktuellen Datenlage die Spiroergometrie ein sensibles, nichtinvasives Instrument sowohl zur frühzeitigen als auch späteren Beurteilung eines Therapieerfolges nach pulmonaler Thrombendarteriektomie bei CTEPH und sollte somit eine breitere Anwendung im klinischen Alltag finden. Darüber hinaus wurden im gleichen Setting Parameter der Hämodynamik (mittels Rechtsherzkatheteruntersuchung), der Echokardiographie, des 6-Minuten-Gehtests sowie der Borg-Dyspnoe-Score, der Borg-Erschöpfungs-Score und die WHO-Funktionsklasse untersucht.In the present dissertation, functional capacity was evaluated in 61 patients with CTEPH using spiroergometry over time before and after pulmonary thromboendarterectomy. Here, a significant improvement in respiratory efficiency and gas exchange disturbance was demonstrated early postoperatively. Later postoperatively, further improvement in oxygen uptake and respiratory efficiency on exercise was demonstrated due to a training effect. Compared with previously published studies, the work presented here has investigated considerably more spiroergometric parameters and thus made a further contribution to the understanding of cardiopulmonary effects of pulmonary thromboendarterectomy. Ultimately, adding the current data, we believe that spiroergometry is a sensitive, noninvasive tool for both early and later assessment of therapeutic success after pulmonary thromboendarterectomy for CTEPH and thus should find wider application in clinical practice. In addition, parameters of hemodynamics (by right heart catheterization), echocardiography, the 6-minute-walk-test, as well as the Borg dyspnea score, the Borg fatigue score, and the WHO functional class were studied in the same setting

Carolvs Magnvs, Princeps Graece Et Latine Doctvs Ac In Saxonia Inferiore Et Reliqva Germania Primvs Vtrivsqve Lingvae Parens : Qvo Argvmento, Consvetam Examinis Avctvmnalis Lvstrationem IV. Idvvm Octobris, Et Seqventibvs Diebvs Antiqvo Ritv Celebrandam, Venerabili Ephororvm Collegio, Convocatis In Honoratae Praesentiae Partes Vtrivsqve Fori, Tam In Cvria, Qvam Ecclesia, Patronis, Et Literarvm Amatoribvs, Decenter Indicit M. Ioannes Doppertvs, Rector Scholae Sneebergensis ; [P. P. Dominica XIX. post Triados solennia. MDCCXXII.]

Vorlageform des Erscheinungsvermerks: Impressit Henr. Fvlda. - Erscheinungsort nach dem Wirkungsort des Druckers bestimmt - Erscheinungsjahr nach der Datierung am Textende bestimm

The transformation of the Spoorzone

This thesis is focussed on the Spoorzone, an area in the city centre of Tilburg. This area was reallocated after it was purchased from the NS, creating a large opportunity for redevelopment in the city centre of Tilburg. Ten years after the purchase the Spoorzone can be seen as a largely developed area in which several modern themes like attractiveness and design. The effects which these themes have on the city centre are analysed and listed in the research, showing which effects have the biggest impact on the feeling of attractiveness by the redevelopment. In the research different effects are listed and grounded in theory written by names like Gehl and Jacobs. The ideology by these thinkers is integrated into the project by using the basics of the theories in the interview guides used to analyse the effects of the redevelopment. This casestudy on Tilburg involves interviews with several experts on the topics in the region and stakeholders present in the Spoorzone as well as inhabitants of Tilburg. The research is aimed to see whether the effects of the redevelopment have positively impacted the feeling of attractiveness in the city centre of Tilburg

Hoc Propter Commendandi Mvnvs Viatico Iter Ad Misniae Athenas, Lipsiam. Io. Friderici Steinbachii, Avrobacensis Inter Variscos, Ivvenis Diligentiae Eximiae, Indolisqve Probae, Singvlari Indvctvs Amore Remvneratvr M. Ioannes Doppertvs, Rector Schol. Sneeb.

Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Impressit Henricvs Fvlda. - Erscheinungsjahr nach der Datierung am Schluß bestimm

Crastino Die Svb Vesperam Avdita Hora IV. Schola Nostra Memoriam Theophaneias S. Natalis Commvnis Mortalivm Sospitatoris Solemniter, Locoqve Consveto Celebrabit, Et Simvl Religiosa Mentis Observantia Divinvm Nascendi Beneficivm Cvm Pvblico Coetv Recolet, Ad Qvam Solemnitatem Venerandos Maximeqve Spectatos Lycei Nostri Ephoros, Amplissimos Ac Nobilissimos Vtrivsqve Cvriae Patres, Et Omnes, Qvot Qvot Jvcvndis Mvsarvm Exercitiis Capivntvr, Sacriqve Natalis Argvmento Permvlcentvr, Invitat, Verbisqve Honorificis Convocat [ P. P. ipsis natalium Christi solennibus MD CCIV.] / Ioannes Doppertvs, Lycei Sneeberg. Rector.

Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Sneebergae Praelo Henrici Fulda