Qualita igienico-sanitaria e composizione del latte d'asina di razza sarda destinato al consumo umano diretto.

Considerato il crescente interesse verso il latte d’asina che per la sua particolare composizione simile al latte umano è stato recentemente rivalutato quale alimento adatto soggetti a rischio e in special modo per bambini affetti da allergie alimentari, si è ritenuto interessante studiare il latte della razza sarda al fine di valutare le sue caratteristiche qualitative ed evidenziarne eventuali differenze rispetto al latte delle altre razze asinine. Lo studio è stato effettuato su 40 campioni di latte individuale ottenuto da n. 10 asine di razza Sarda e da n. 2 asine di razza Sarda var. albina appartenenti alla colonia dislocata nei pressi di Campu Perdu nella costa orientale dell’isola dell’Asinara ( Porto Torres – Sassari). I campioni di latte sono stati analizzati presso i laboratori accreditati secondo la norma UNI EN ISO/IEC 17025 dell’Istituto Zooprofilattico Sperimentale della Sardegna. I risultati del nostro studio hanno dimostrato la sostanziale similitudine delle caratteristiche chimico-fisiche ed igienico-sanitarie del latte d’asina di razza Sarda rispetto al latte delle altre razze più diffuse e studiate in Italia (Martina Franca, Amiata e Ragusana). Come riportato da altri autori, si sottolinea la necessità di una normativa specifica e completa in materia di produzione e commercializzazione del latte d’asina ad uso alimentare che definisca limiti critici per i parametri di tipo igienico sanitario utilizzabili quale strumento per una maggiore tutela della sicurezza e del valore nutrizionale del prodotto considerata la peculiare destinazione per categorie di consumatori a rischio quali bambini e anziani

Clinical phenotypes in adult patients with bronchiectasis

Bronchiectasis is a heterogeneous disease. This study aimed at identifying discrete groups of patients with different clinical and biological characteristics and long-term outcomes. This was a secondary analysis of five European databases of prospectively enrolled adult outpatients with bronchiectasis. Principal component and cluster analyses were performed using demographics, comorbidities, and clinical, radiological, functional and microbiological variables collected during the stable state. Exacerbations, hospitalisations and mortality during a 3-year follow-up were recorded. Clusters were externally validated in an independent cohort of patients with bronchiectasis, also investigating inflammatory markers in sputum. Among 1145 patients (median age 66 years; 40% male), four clusters were identified driven by the presence of chronic infection with Pseudomonas aeruginosa or other pathogens and daily sputum: "Pseudomonas" (16%), "Other chronic infection" (24%), "Daily sputum" (33%) and "Dry bronchiectasis" (27%). Patients in the four clusters showed significant differences in terms of quality of life, exacerbations, hospitalisations and mortality during follow-up. In the validation cohort, free neutrophil elastase activity, myeloperoxidase activity and interleukin-1\u3b2 levels in sputum were significantly different among the clusters. Identification of four clinical phenotypes in bronchiectasis could favour focused treatments in future interventional studies designed to alter the natural history of the disease

Prospect for Charge Current Neutrino Interactions Measurements at the CERN-PS

Tensions in several phenomenological models grew with experimental results on neutrino/antineutrino oscillations at Short-Baseline (SBL) and with the recent, carefully recomputed, antineutrino fluxes from nuclear reactors. At a refurbished SBL CERN-PS facility an experiment aimed to address the open issues has been proposed [1], based on the technology of imaging in ultra-pure cryogenic Liquid Argon (LAr). Motivated by this scenario a detailed study of the physics case was performed. We tackled specific physics models and we optimized the neutrino beam through a full simulation. Experimental aspects not fully covered by the LAr detection, i.e. the measurements of the lepton charge on event-by-event basis and their energy over a wide range, were also investigated. Indeed the muon leptons from Charged Current (CC) (anti-)neutrino interactions play an important role in disentangling different phenomenological scenarios provided their charge state is determined. Also, the study of muon appearance/disappearance can benefit of the large statistics of CC muon events from the primary neutrino beam. Results of our study are reported in detail in this proposal. We aim to design, construct and install two Spectrometers at "NEAR" and "FAR" sites of the SBL CERN-PS, compatible with the already proposed LAr detectors. Profiting of the large mass of the two Spectrometers their stand-alone performances have also been exploited.Comment: 70 pages, 38 figures. Proposal submitted to SPS-C, CER

Cidadania política e voto do analfabeto no Brasil

ResumoEste trabalho examina, a partir de uma perspectiva histórica, o direito político de cidadania dos analfabetos no Brasil. De 1889 a 1985, havia uma lei estabelecendo a obrigatoriedade de ser alfabetizado para poder ter o direito de voto. Tal conexão entre voto e educação tornou-se uma fonte de exclusão social e de injustiça. No âmbito das lutas pela democracia no país, os analfabetos conquistaram o direito político de voto. Dessa maneira, eles começaram a participar das decisões políticas concernentes às suas próprias vidas, mesmo que continuem sem ter o direito de serem eleitos. Palavras-chave: Educação e voto; Cidadania política; Voto do analfabeto; Estado e sociedade civil AbstractThis work examines, from a historical perspective, the illiterate’s political right of citizenship in Brazil. From 1889 to 1985, there was a law establishing the obligation to be literate so to have the right to vote. This connection between vote and education became a source of social exclusion and injustice. In the scope of the social struggles for democracy, the illiterates conquered the political right to vote. In this manner, they started to participate at the political decisions referring to their own lives, even if they continue not having the right to be elected. Keywords: Education and vote; Political citizenship; Vote of the illiterate; State and civil society  

Search for anomalies in the neutrino sector with muon spectrometers and large LArTPC imaging detectors at CERN

A new experiment with an intense ~2 GeV neutrino beam at CERN SPS is proposed in order to definitely clarify the possible existence of additional neutrino states, as pointed out by neutrino calibration source experiments, reactor and accelerator experiments and measure the corresponding oscillation parameters. The experiment is based on two identical LAr-TPCs complemented by magnetized spectrometers detecting electron and muon neutrino events at Far and Near positions, 1600 m and 300 m from the proton target, respectively. The ICARUS T600 detector, the largest LAr-TPC ever built with a size of about 600 ton of imaging mass, now running in the LNGS underground laboratory, will be moved at the CERN Far position. An additional 1/4 of the T600 detector (T150) will be constructed and located in the Near position. Two large area spectrometers will be placed downstream of the two LAr-TPC detectors to perform charge identification and muon momentum measurements from sub-GeV to several GeV energy range, greatly complementing the physics capabilities. This experiment will offer remarkable discovery potentialities, collecting a very large number of unbiased events both in the neutrino and antineutrino channels, largely adequate to definitely settle the origin of the observed neutrino-related anomalies.Comment: Contribution to the European Strategy for Particle Physics - Open Symposium Preparatory Group, Kracow 10-12 September 201

Intravitreal Dexamethasone in Patients with Wet Age-Related Macular Degeneration Resistant to Anti-VEGF: A Prospective Pilot Study

Purpose. To evaluate the efficacy and safety of a single intravitreal dexamethasone implant (DXI) combined with intravitreal antivascular endothelial growth factor (anti-VEGF) therapy, in patients with neovascular age-related macular degeneration (wet-AMD) resistant to conventional treatment. Methods. In this randomized, controlled pilot study, 16 eyes of 15 patients, unresponsive to anti-VEGF therapy, were enrolled and randomly assigned to two groups: DXI + anti-VEGF (treatment group: 11 eyes) and monthly anti-VEGF alone (control group: 5 eyes). Patients were treated at baseline and followed for 6 months. Best corrected visual acuity (BCVA), optical coherence tomography (OCT) parameters, and fluorescein angiography (FA) were evaluated. Results. Eight eyes (72.7%) in the treatment group and 2 eyes in the control group (40%) showed complete retinal fluid resorption (p=0.049). BCVA showed no significant change from baseline in both the treatment group and the control group (p=0.40 and p=0.29, respectively). Both median central foveal thickness (CFT) and median macular volume showed a greater reduction from baseline in the treatment group. Conclusion. In patients showing an incomplete response to anti-VEGF therapy, DXI combined with intravitreal anti-VEGF seems to improve retinal fluid resorption without functional advantage. This trial is registered with ACTRN12618001102268

Bio-inspired relevant interaction modelling in cognitive crowd management

Cognitive algorithms, integrated in intelligent systems, represent an important innovation in designing interactive smart environments. More in details, Cognitive Systems have important applications in anomaly detection and management in advanced video surveillance. These algorithms mainly address the problem of modelling interactions and behaviours among the main entities in a scene. A bio-inspired structure is here proposed, which is able to encode and synthesize signals, not only for the description of single entities behaviours, but also for modelling cause–effect relationships between user actions and changes in environment configurations. Such models are stored within a memory (Autobiographical Memory) during a learning phase. Here the system operates an effective knowledge transfer from a human operator towards an automatic systems called Cognitive Surveillance Node (CSN), which is part of a complex cognitive JDL-based and bio-inspired architecture. After such a knowledge-transfer phase, learned representations can be used, at different levels, either to support human decisions, by detecting anomalous interaction models and thus compensating for human shortcomings, or, in an automatic decision scenario, to identify anomalous patterns and choose the best strategy to preserve stability of the entire system. Results are presented in a video surveillance scenario , where the CSN can observe two interacting entities consisting in a simulated crowd and a human operator. These can interact within a visual 3D simulator, where crowd behaviour is modelled by means of Social Forces. The way anomalies are detected and consequently handled is demonstrated, on synthetic and also on real video sequences, in both the user-support and automatic modes

Observation of weak neutral current neutrino production of J/ψJ/\psi

Observation of \jpsi production by neutrinos in the calorimeter of the CHORUS detector exposed to the CERN SPS wide-band \numu beam is reported. A spectrum-averaged cross-section $\sigma^{\mathrm{J/\psi}}$ = (6.3 $\pm$ 3.0) $\times \mathrm{10^{-41}~cm^{2}}$ is obtained for 20 GeV $\leq E_{\nu} \leq$ 200 GeV. The data are compared with the theoretical model based on the QCD Z-gluon fusion mechanism

Two naphthalene degrading bacteria belonging to the genera Paenibacillus and Pseudomonas isolated from a highly polluted lagoon perform different sensitivities to the organic and heavy metal contaminants

Two bacterial strains were isolated in the presence of naphthalene as the sole carbon and energy source from sediments of the Orbetello Lagoon, Italy, which is highly contaminated with both organic compounds and metals. 16S rRNA gene sequence analysis of the two isolates assigned the strains to the genera Paenibacillus and Pseudomonas. The effect of different contaminants on the growth behaviors of the two strains was investigated. Pseudomonas sp. ORNaP2 showed a higher tolerance to benzene, toluene, and ethylbenzene than Paenibacillus sp. ORNaP1. In addition, the toxicity of heavy metals potentially present as co-pollutants in the investigated site was tested. Here, strain Paenibacillus sp. ORNaP1 showed a higher tolerance towards arsenic, cadmium, and lead, whereas it was far more sensitive towards mercury than strain Pseudomonas sp. ORNaP2. These differences between the Gram-negative Pseudomonas and the Gram-positive Paenibacillus strain can be explained by different general adaptive response systems present in the two bacteria