A Fast Multigrid Algorithm for Energy Minimization Under Planar Density Constraints

The two-dimensional layout optimization problem reinforced by the efficient space utilization demand has a wide spectrum of practical applications. Formulating the problem as a nonlinear minimization problem under planar equality and/or inequality density constraints, we present a linear time multigrid algorithm for solving correction to this problem. The method is demonstrated on various graph drawing (visualization) instances

How Did Dread Pirate Roberts Acquire and Protect his Bitcoin Wealth?

Abstract. The Bitcoin scheme is one of the most popular and talked about alternative payment schemes. One of the most active parts of the Bitcoin ecosystem was the Silk Road marketplace, in which highly illegal substances and services were traded. It was run by a person who called himself Dread Pirate Roberts (DPR), whose bitcoin holdings are esti-mated to be worth hundreds of millions of dollars at today’s exchange rate. On October 1-st 2013, the FBI arrested a 29 year old person named Ross William Ulbricht, claiming that he is DPR, and seizing a small fraction of his bitcoin wealth. In this paper we use the publicly available record to trace the evolution of his holdings in order to find how he ac-quired and how he tried to hide them from the authorities. In particular, we trace the amounts he received and the amounts he transferred out of his accounts, and show that all his Silk Road commissions from the months of May, June and September 2013, along with numerous other amounts, were not seized by the FBI. This analysis demonstrates the power of data mining techniques in analyzing large payment systems, and especially publicly available transaction graphs of the type provided by the Bitcoin scheme

Harnessing Information Technology to Improve the Process of Students’ Evaluations of Teaching: An Exploration of Students’ Critical Success Factors of Online Evaluations

This paper discusses the relative advantage offered by online Students’ Evaluations of Teaching (SET) and describes a study conducted at a Canadian university to identify critical success factors of online evaluations from students’ point of view. Factors identified as important by the students include anonymity, ease of use (of both SET survey and system), accessibility, publication of results, subsequent adjustments to the course, SET survey redesign, system reliability, incentives, reminders, and conveying the importance of the SET survey to students. We discuss key implications of the factors identified to faculty and survey administrators

Importance of multispin couplings in renormalized Hamiltonians Phys

We introduce a Monte Carlo approach to the calculation of more distant renormalized interactions with higher accuracy than is possible with previous methods. We have applied our method to study the effects of multispin interactions, which turn out to be far more important than commonly assumed. Even though the individual multispin interactions usually have smaller coupling constants than two-spin interactions, they can dominate the effects of two-spin interactions because they are so numerous

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy