Nose cone mounted heat resistant antenna Patent

Nose cone mounted heat resistant antenna comprising plurality of adjacent layers of silica not introducing paths of high thermal conductivity through ablative shiel

Editorial: EFSA calls for integrated and coordinated actions at EU and international levels to address global declines of pollinators

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Tabu Search for Frequency Assignment in Mobile Radio Networks

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A genetic algorithm to minimize chromatic entropy

We present an algorithmic approach to solving the problem of chromatic entropy, a combinatorial optimization problem related to graph coloring. This problem is a component in algorithms for optimizing data compression when computing a function of two correlated sources at a receiver. Our genetic algorithm for minimizing chromatic entropy uses an order-based genome inspired by graph coloring genetic algorithms, as well as some problem-specific heuristics. It performs consistently well on synthetic instances, and for an expositional set of functional compression problems, the GA routinely finds a compression scheme that is 20-30% more efficient than that given by a reference compression algorithm

Extending standard testing period in honeybees to predict lifespan impacts of pesticides and heavy metals using dynamic energy budget modelling

Concern over reported honeybee (Apis mellifera spp.) losses has highlighted chemical exposure as a risk. Current laboratory oral toxicity tests in A. mellifera spp. use short-term, maximum 96 hour, exposures which may not necessarily account for chronic and cumulative toxicity. Here, we use extended 240 hour (10 day) exposures to examine seven agrochemicals and trace environmental pollutant toxicities for adult honeybees. Data were used to parameterise a dynamic energy budget model (DEBtox) to further examine potential survival effects up to 30 day and 90 day summer and winter worker lifespans. Honeybees were most sensitive to insecticides (clothianidin > dimethoate ≫ tau-fluvalinate), then trace metals/metalloids (cadmium, arsenic), followed by the fungicide propiconazole and herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). LC50s calculated from DEBtox parameters indicated a 27 fold change comparing exposure from 48 to 720 hours (summer worker lifespan) for cadmium, as the most time-dependent chemical as driven by slow toxicokinetics. Clothianidin and dimethoate exhibited more rapid toxicokinetics with 48 to 720 hour LC50s changes of <4 fold. As effects from long-term exposure may exceed those measured in short-term tests, future regulatory tests should extend to 96 hours as standard, with extension to 240 hour exposures further improving realism

Drug Pricing in the United States: A Comparison with Canada and Mexico

The purpose of this study was to assess prescription drug pricing in the United States compared with that in Canada and Mexico. The study was designed to focus on ACE inhibitors in order to gather a limited, yet meaningful outcome. Prices of eight ACE inhibitors and their generic equivalents were gathered for the United States, Canada, and Mexico via Walgreens and international online pharmacies, respectively. The differences in price per pill for Canada and Mexico when paired against the United States were analyzed using t statistics. The results indicate there is a significant price difference for brand name and generic ACE inhibitors in Canada and the United States. However, no significant cost difference was determined for brand name or generic ACE inhibitors in Mexico and the United States. Prices for brand name and generic ACE inhibitors in Canada were found to be lower than those in Mexico

Implementing Animal-Assisted Therapy During Psychiatric Intakes

Introduction: The purpose of this evidence-based project is to determine if Animal-Assisted Therapy (AAT) causes improvements in veterans’ feelings of anger, anxiety, depression, and suicidality in the acute psychiatric setting during psychiatric evaluations. The project aims to provide veterans with an additional way to experience short-term relief from symptoms while discussing their symptomology with mental health providers. Background: The prevalence of depression is 20% higher in veterans than in that of the general population. Similarly, it has been shown that 23% of all veterans using VA care have had PTSD at some point in their lives. In the Psychiatric Emergency Clinic (PEC) at the VA in La Jolla, PTSD, depression, anxiety, and substance use disorder are among the most common diagnoses. These patients often struggle with mood lability, anxiety, and avoidance, making it difficult for providers to get a thorough history to guide recommendations. Utilizing animal assisted therapy (AAT) during the appointment may put patients at ease and provide a comforting distraction when discussing emotionally triggering subjects. Methods: This project evaluates self-reported feelings of anger, anxiety, depression, and suicidal urges in 15 veterans both immediately before and immediately after a psychiatric intake where AAT took place. Using the Brief Mood Survey, veterans rated their symptoms in each category on a scale of 0-5. The Brief Mood Survey (BMS) was utilized to determine baseline pre-intervention mood scores, and a post-intervention survey was administered to determine the efficacy of the intervention when compared to baseline. Results: The BMS scores, which included 5 subscales per category for depression, anger, and anxiety and 2 subscales for suicidal urges, were used to evaluate the efficacy of AAT during psychiatric intakes. The results showed improvements in post-intervention scores compared to pre-intervention scores in all categories, with the most significant improvements seen in the areas of anger and suicidal urges. Evaluation: The marked improvements that were observed in all mood categories on the BMS suggest that AAT is effective as a supplemental intervention for utilization during psychiatric intakes in the acute psychiatric setting

Dispelling urban myths about default uncertainty factors in chemical risk assessment - Sufficient protection against mixture effects?

© 2013 Martin et al.; licensee BioMed Central LtdThis article has been made available through the Brunel Open Access Publishing Fund.Assessing the detrimental health effects of chemicals requires the extrapolation of experimental data in animals to human populations. This is achieved by applying a default uncertainty factor of 100 to doses not found to be associated with observable effects in laboratory animals. It is commonly assumed that the toxicokinetic and toxicodynamic sub-components of this default uncertainty factor represent worst-case scenarios and that the multiplication of those components yields conservative estimates of safe levels for humans. It is sometimes claimed that this conservatism also offers adequate protection from mixture effects. By analysing the evolution of uncertainty factors from a historical perspective, we expose that the default factor and its sub-components are intended to represent adequate rather than worst-case scenarios. The intention of using assessment factors for mixture effects was abandoned thirty years ago. It is also often ignored that the conservatism (or otherwise) of uncertainty factors can only be considered in relation to a defined level of protection. A protection equivalent to an effect magnitude of 0.001-0.0001% over background incidence is generally considered acceptable. However, it is impossible to say whether this level of protection is in fact realised with the tolerable doses that are derived by employing uncertainty factors. Accordingly, it is difficult to assess whether uncertainty factors overestimate or underestimate the sensitivity differences in human populations. It is also often not appreciated that the outcome of probabilistic approaches to the multiplication of sub-factors is dependent on the choice of probability distributions. Therefore, the idea that default uncertainty factors are overly conservative worst-case scenarios which can account both for the lack of statistical power in animal experiments and protect against potential mixture effects is ill-founded. We contend that precautionary regulation should provide an incentive to generate better data and recommend adopting a pragmatic, but scientifically better founded approach to mixture risk assessment. © 2013 Martin et al.; licensee BioMed Central Ltd.Oak Foundatio

Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations

Organic anion transporters (OATs) belong to a subgroup of the solute carrier 22 transporter family. OATs have a central role in xenobiotic disposition affecting the toxicokinetics of its substrates and inter-individual differences in their expression, activity and function impact both toxicokinetics and toxicodynamics. Amongst OATs, OAT1 (solute carrier family 22 member 6) is involved in the urinary excretion of many xenobiotics bringing substrates into renal proximal tubular cells which can then be secreted across the apical membrane into the tubule lumen. The mycotoxin ochratoxin A has been shown to have a high affinity for OAT1, which is an important renal transporter involved in its urinary excretion. Nowadays, molecular modeling techniques are widely applied to assess protein-ligand interactions and may provide a tool to depict the mechanic of xenobiotic action be it toxicokinetics or toxicodynamics. This work provides a structured pipeline consisting of docking and molecular dynamic simulations to study OAT1-ligand interactions and the impact of OAT1 polymorphisms on such interactions. Such a computational structure-based analytical framework allowed to: i) model OAT1-substrate complex formation and depict the features correlating its sequence, structure and its capability to recruit substrates; and ii) investigate the impact of OAT1 missense mutations on substrate recruitment. Perspectives on applying such a structured pipeline to xenobiotic-metabolising enzymes are discussed