Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers

Background: Methods for rapid assessment of interactions of small molecules with membrane proteins in detergent are lacking.  Results: Thermostability measurements of mitochondrial transporters display informative trends about detergent, lipid, substrate, and inhibitor interactions.  Conclusion: Mechanistic insights are obtained by studying the thermostability of mitochondrial transporters.  Significance: Information about the nature of compound interactions with membrane proteins can be obtained rapidly

Credit Surety Fund: A Credit Innovation for Micro, Small, and Medium-Sized Enterprises in the Philippines

Micro, small, and medium-sized enterprises are a backbone of the Philippine economy. One factor that hinders the growth of these enterprises is their difficulty in accessing finance from banks and other financial institutions. The Credit Surety Fund (CSF) was established to help these enterprises and other organizations become creditworthy and bankable. The CSF is a credit guarantee program initiated by the Bangko Sentral ng Pilipinas that enables enterprises and cooperatives to gain easier access to loans from banks without providing collateral. The CSF pools contributions from cooperatives and nongovernment organizations, local government units, institutions such as the Development Bank of the Philippines, the Land Bank of the Philippines, the Industrial Guarantee and Loan Fund, and other organizations. In this way, it is a public-private partnership that links the key players of the economy to empower enterprises and cooperatives

Comparative mitochondrial proteomics: perspective in human diseases

Mitochondria are the most complex and the most important organelles of eukaryotic cells, which are involved in many cellular processes, including energy metabolism, apoptosis, and aging. And mitochondria have been identified as the "hot spot" by researchers for exploring relevant associated dysfunctions in many fields. The emergence of comparative proteomics enables us to have a close look at the mitochondrial proteome in a comprehensive and effective manner under various conditions and cellular circumstances. Two-dimensional electrophoresis combined with mass spectrometry is still the most popular techniques to study comparative mitochondrial proteomics. Furthermore, many new techniques, such as ICAT, MudPIT, and SILAC, equip researchers with more flexibilities inselecting proper methods. This article also reviews the recent development of comparative mitochondrial proteomics on diverse human diseases. And the results of mitochondrial proteomics enhance a better understanding of the pathogenesis associated with mitochondria and provide promising therapeutic targets

Hydrogen production from glycerin reforming

Thesis (M.S.)--University of Hawaii at Manoa, 2006.Includes bibliographical references (leaves 69-72).vii, 89 leaves, bound ill. 29 cmFollowing a factorial experimental design, a series of tests were performed to investigate the effects of operating parameters; oxygen to carbon ratio (O/C), steam to carbon ratio (SIC) and temperature (T), on reforming glycerin to a H2 rich gas. A mathematical model defining the effect of those three variables was derived., and used for improving the reaction hydrogen yield. From the range of experimental conditions tested it was concluded that OIC, as well as the interaction between OIC and temperature had the most important effects on H2 yield. 4.5 mole of hydrogen were produced per mole of glycerin at experimental conditions of O/C=1, S/C=2.2, and T=804°C. This is 65% of the maximum theoretical yield, and 90% of the yield predicted by thermochemical equilibrium. 1.4 moles of carbon monoxide per mole of glycerin were also produced., presenting a potential for an additional 1.4 mole hydrogen per mole glycerin. A water gas shift reaction was then used., and its operating temperature optimized, in order to convert the reformate gas CO into hydrogen by combining it with water. Results were satisfying, with a final yield of 5.3 moles H2 I mole glycerin, which is 75% of the maximum stoichiometric hydrogen yield. Crude glycerin, obtained from biodiesel production, was finally tested (without a water gas shift) as a feed to compare it with pure glycerin used throughout the tests. The initial results were very encouraging, almost identical to those of pure glycerin, but carbon formation quickly became a problem. Possible contaminants causing the coking may include methanol, chloride and sodium cations, and free fatty acids, all present in crude glycerin as byproducts of biodiesel synthesis

Mitochondrial uncoupling proteins: new insights from functional and proteomic studies.

Mitochondria are the major sites of ATP synthesis through oxidative phosphorylation, a process that is weakened by proton leak. Uncoupling proteins are mitochondrial membrane proteins specialized in inducible proton conductance. They dissipate the proton electrochemical gradient established by the respiratory chain at the expense of reducing substrates. Several physiological roles have been suggested for uncoupling proteins, including roles in the control of the cellular energy balance and in preventive action against oxidative stress. This review focuses on new leads emerging from comparative proteomics about the involvement of uncoupling protein in the mitochondrial physiology. A brief overview on uncoupling proteins and on proteomics applied to mitochondria is also presented herein

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

http://www.sciencedirect.com/science/article/B6W8G-4T72WXD-1/2/734055ec11eadc8100fee13e06c683d

De la pratique de l'agriculture.

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Forts de la Meuse. Place de Namur : Images et textes de la construction des forts (1887-1892). Edition introduite et commentée

De 1887 à 1891, la construction de neuf forts bétonnés et cuirassés fait de Namur une place forte moderne, selon les plans du général Alexis Brialmont. Les entrepreneurs font réaliser à cette occasion un reportage photographique exceptionnel, dont ils offrent l’album à Brialmont et à des ministres. Ces photos sont publiées pour la première fois dans leur intégralité, accompagnées d’extraits de la presse locale et précédées de la présentation des chantiers par les ingénieurs, tous textes inédits. L’équipe de rédaction des Amis de la citadelle les introduit par des textes explicatifs synthétiques, donnant ainsi le contexte général de ces documents historiques qui révèlent une face peu connue des fortifications namuroises. Les photographies de la construction des forts de la Meuse présentées dans cette monographie ont plus de 120 ans. Elles sont extraites d’un album concernant la place de Namur et actuellement conservé dans cette même ville. Dans un souci de cohérence éditoriale, nous avons fait le choix rédactionnel de travailler avec cet album, propriété d’un membre de l’association. A notre connaissance, les plaques originales ayant servi aux tirages de ces photographies n’existent plus. C’est donc à partir des tirages anciens que nous avons travaillé et nous assumons pleinement ce choix. Ainsi, de nombreuses photos de l’album originale ont, hélas, beaucoup pâli et leur reproduction s’est avérée parfois difficile pour un résultat quelquefois décevant. Mais cet ouvrage n’est pas une édition d’art mais l’occasion de faire partager des documents historiques exceptionnels et de les remettre dans leur contexte