12,050 research outputs found
Enumerating Regular Objects associated with Suzuki Groups
We use the M\"obius function of the simple Suzuki group Sz(q) to enumerate
regular objects such as maps, hypermaps, dessins d'enfants and surface
coverings with automorphism groups isomorphic to Sz(q).Comment: 20 page
A role for chromatin remodellers in replication of damaged DNA
In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure. There are two isoforms of the Remodels the Structure of Chromatin (RSC) remodelling complex in yeast. We show that deletion of RSC2 results in a dramatic reduction in the level of PCNA ubiquitination after DNA-damaging treatments, whereas no such effect was observed after deletion of RSC1. Similarly, depletion of the BAF180 component of the corresponding PBAF (Polybromo BRG1 (Brahma-Related Gene 1) Associated Factor) complex in human cells led to a similar reduction in PCNA ubiquitination. Remarkably, we found that depletion of BAF180 resulted after UV-irradiation, in a reduction not only of ubiquitinated PCNA but also of chromatin-associated unmodified PCNA and Rad18 (the E3 ligase that ubiquitinates PCNA). This was accompanied by a modest decrease in fork progression. We propose a model to account for these findings that postulates an involvement of PBAF in repriming of replication downstream from replication forks blocked at sites of DNA damage. In support of this model, chromatin immunoprecipitation data show that the RSC complex in yeast is present in the vicinity of the replication forks, and by extrapolation, this is also likely to be the case for the PBAF complex in human cells
Application of a Solar Wind Model Driven by Turbulence Dissipation to a 2D Magnetic Field Configuration
Although it is widely accepted that photospheric motions provide the energy
source and that the magnetic field must play a key role in the process, the
detailed mechanisms responsible for heating the Sun's corona and accelerating
the solar wind are still not fully understood. Cranmer et al. (2007) developed
a sophisticated, 1D, time-steady model of the solar wind with turbulence
dissipation. By varying the coronal magnetic field, they obtain, for a single
choice of wave properties, a realistic range of slow and fast wind conditions
with a sharp latitudinal transition between the two streams. Using a 1D,
time-dependent model of the solar wind of Lionello et al. (2014), which
incorporates turbulent dissipation of Alfv\'en waves to provide heating and
acceleration of the plasma, we have explored a similar configuration, obtaining
qualitatively equivalent results. However, our calculations suggest that the
rapid transition between slow and fast wind suggested by this 1D model may be
disrupted in multidimensional MHD simulations by the requirement of transverse
force balance
Analysis of data systems requirements for global crop production forecasting in the 1985 time frame
Data systems concepts that would be needed to implement the objective of the global crop production forecasting in an orderly transition from experimental to operational status in the 1985 time frame were examined. Information needs of users were converted into data system requirements, and the influence of these requirements on the formulation of a conceptual data system was analyzed. Any potential problem areas in meeting these data system requirements were identified in an iterative process
Glass shell manufacturing in space
Residual gases always found in glass shells are CO2, O2 and N2. In those cases where high water vapor pressure is maintained in the furnace, water is also found in the shells. Other evidence for the existence of water in shells is the presence of water-induced surface weathering of the interior shell surface. Water and CO2 are the predominant volatiles generated by the pyrolysis of both inorganic and hydrolyzed metal-organic gels. The pyrolysates of unhydrolyzed metal-organic gels also contain, in addition to water and CO2, significant levels of organic volatiles, such as ethanol and some hydrocarbons; on complete oxidation, these produce CO2 and water as well. Water is most likely the initial blowing agent, it is produced copiously during the initial stages of heating. In the later stages, CO2 becomes the dominant gas as H2O is lost at increasing rates. Water in the shell arises mainly from gel dehydration, CO2 by sodium bicarbonate/carbonate decomposition and carbon oxidation, and O2 and N2 by permeation of the ambient furnace air through the molten shell wall
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