Information and Communication Technologies in Areas of Limited Statehood

This paper analyzes the effects of information and communication technology (ICT) on governance where the state‘s ability to authoritatively implement and enforce political decisions is weak or functionally absent – areas of limited statehood (AoLS). How do ICTs influence the provision of collective goods in AoLS, especially in policy fields such as security, welfare and the environment? In addressing this question we focus on the emergence of ICT- enabled forms of steering. Virtual organizations such as Ushahidi and FrontlineSMS enable the coordination of collective goods without the same level of hierarchical structure historically associated with traditional forms of governance. The focus lies on quasi-organizational forms that rely on mass collaborative action across electronic networks. The consideration of these questions is supported by fieldwork in Africa in 2011, and on previous research in Afghanistan and various African countries in 2010. The paper concludes with some tentative hypotheses on the interconnection between ICT, statehood and governance.Dieses Arbeitspapier analysiert die Effekte von Informations- und Kommunikationstechnologien (ICT) in Räumen begrenzter Staatlichkeit (RbS) mit Bezug auf Governance. Es geht dabei v.a. der Frage nach, wie ICTs die Bereitstellung kollektiver Güter insbesondere in den Politikfeldern Sicherheit, Wohlfahrt und Umwelt beeinflussen. Bei der Beantwortung dieser Frage konzentrieren wir uns auf die Entstehung neuer Steuerungsformen, die auf ICTs basieren. Virtuelle Organisationen wie Ushahidi oder FrontlineSMS beispielsweise ermöglichen die Erbringung kollektiver Güter auch ohne staatlich-hierarchische Strukturen, die in einem traditionellen Verständnis häufig als Voraussetzung von Governance betrachtet werden. Unser Fokus liegt somit auf Governance-Formen die auf kollektivem Handeln über elektronische Netzwerke basieren. Die Diskussion dieser Fragen wird durch die Ergebnisse von Forschungsaufenthalten illustriert, die in den Jahren 2010 und 2011 in Afghanistan und verschiedenen afrikanischen Staaten stattgefunden haben. Das Paper endet mit einigen vorläufigen Hypothesen zu der Verbindung von ICTs, Staatlichkeit und Governance

A Macro-Quantitative Analysis of Governance Performance

“State-Building” wird vielerorts als Prinzip moderner Entwicklungspolitik angesehen. Dies beruht auf der Annahme, dass dem modernen Staat eine zentrale Rolle im Bereich der Gewährleistung von Governance-Dienstleistungen zukommt. Das Verhältnis zwischen Staatlichkeit und so verstandener „Governance“ ist jedoch alles andere als klar. Auf Basis eines makro-quantitativen Ansatzes, analysieren wir die Performanz von Staaten in Bereichen wie Sicherheit, Gesundheit, Bildung, ökonomische Subsistenz, Infrastruktur und Umwelt und fragen, inwieweit Staatlichkeit die entsprechenden Unterschiede erklären kann, wenn für diverse andere Faktoren kontrolliert wird, die in den entsprechenden Debatten (v.a. in der Politikwissenschaft und (Entwicklungs-) Ökonomie) als zentral angesehen werden. Drei Ergebnisse der Untersuchung stechen hervor: Erstens – und entgegen der obigen Annahme – lässt sich keine signifikante, konsistente Beziehung zwischen Staatlichkeit und objektiver Governance- Performanz herstellen. Zweitens schneiden die entsprechenden Indikatoren besser ab, wenn es um den Zusammenhang zur subjektiven Wahrnehmung von Governance- Performanz geht, was die Ubiquität der o.g. Annahme bestätigt. Drittens schließlich stellt sich der Grad des „Empowerment“ von Frauen über ganz verschiedene Sachbereiche hinweg als stärkster Prädiktor der Governance- Performanz heraus. Dieses Ergebnis rechtfertigt den Schwerpunkt, den viele Akteure der Entwicklungspolitik derzeit auf die Förderung von Frauen legen.State building is seen as the central tenet of many present-day development efforts. This rests on a global normative script that emphasizes the modern state’s role in providing governance services from security to education to health. However, the relationship between statehood and governance outcomes is not well understood. We use a macro-quantitative approach to analyze state performance in various governance dimensions including security, health, education, economic subsistence, infrastructure, and the environment. We test for the power of statehood in explaining the variation in governance outcomes while controlling for various other factors prominent in the respective debates in political science, economics, and development studies. The analysis yields three interesting results. First, statehood does not have a consistent significant relationship with governance outcomes. It matters more for some outcomes than for others. Second, we find that statehood sometimes performs better at predicting subjective (survey-based) evaluations than at predicting objective measures of governance outcomes (which confirms the ubiquity of the normative script). Finally, we find that the degree of domestic female empowerment performs consistently strong at explaining the variation in governance outcomes. This result is consistent with the policy community’s emphasis on women’s roles in development

Total anomalous pulmonary vein drainage in a 60-year-old woman diagnosed in an ECG-gated multidetector computed tomography : a case report and review of literature

Purpose: Total anomalous pulmonary vein drainage (TAPVD) is a congenital cardiac defect in which there is no connection between pulmonary veins and the left atrium. Pulmonary veins form a confluence independent of the left atrium and drain to a systemic vein. TAPVD types are: supracardiac, cardiac, infracardiac, and mixed. TAPVD accounts for approximately 1.5-2.2% of all congenital heart diseases. This anomaly is usually diagnosed in the neonatal period, and it coexists with atrial septal defect. Adult cases of TAPVD are rarely reported. Case report: We report a rare case of a 60-year-old woman with incidentally found, uncorrected TAPVD in ECG-gated multidetector computed tomography. In previous echocardiographic examinations partial anomalous pulmonary venous return and atrial septal defect were diagnosed. Conclusions: ECG-gated multidetector computed tomography is a valuable diagnostic method for adults with congenital heart disease. It enables evaluation of coronary arteries and simultaneously provides detailed anatomy of great vessels

CDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins

The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. We have isolated cDNAs encoding the six mouse IGFBPs (mIGFBPs). In addition, we studied the mRNA expression of the six mIGFBPs during development and in various adult tissues. Our results show that each of the six mIGFBPs is highly homologous to their human and rat counterparts, whereas only the N and C terminal ends are conserved between the six mIGFBPs. Northern blotting revealed that mIGFBP-2, -3, -4 and -5 genes are already expressed at gestational day 11.5, suggesting a role for these mIGFBPs in embryonal development. In liver, a peak of mIGFBP-1 mRNA expression was found around birth, suggesting a function for mIGFBP-1 in the newborn mouse. Finally, tissue-specific expression of the six mouse IGFBP genes was observed in adult tissues suggesting different roles or modes of actions in adult life

Insulin-like growth factor binding protein-2, 28 kDa an 24 kDa insulin-like growth factor binding protein levels are decreased in fluid of dominant follicles, obtained from normal and polycystic ovaries

In order to investigate potential changes in insulin-like growth factor binding proteins (IGFBPs) during human follicle maturation, we examined the IGFBP profiles in follicular fluid from follicles in different stages of maturation. Samples were obtained from ovaries of women with regular menstrual cycles and of subjects with cycle abnormalities and polycystic ovaries (diagnosed as polycystic ovary syndrome (PCOS)) and analyzed by Western ligand blotting. IGFBPs of 43 kDa, 37 kDa, 31 kDa, a doublet around 28 kDa and a minor band of 24 kDa were detected in follicle fluid of normal non-dominant (size 4) follicles of both regularly menstruating women and PCOS patients. The 43 and 37 kDa IGFBPs could be identified as IGFBP-3 and the 31 kDa IGFBP as IGFBP-2, whereas the 28 kDa IGFBP could not be identified as IGFBP-1, all by immunoblotting techniques. A dramatic decrease in IGFBP-2, the 28 kDa and 24 kDa IGFBPs was observed in follicular fluid of dominant follicles (size > 10 mm) of both regular menstruating individuals and one PCOS patient as compared with follicular fluid of normal non-dominant or atretic follicles. These observations indicate that the PCOS follicle may not be different from normal with respect to IGFBP profiles. Furthermore, these results suggest that at least one of these IGFBPs might be involved in human folliculogenesis

Kidney growth in normal and diabetic mice is not affected by human insulin-like growth factor binding protein-1 administration

Insulin-like growth factor I (IGF-I) accumulates in the kidney following the onset of diabetes, initiating diabetic renal hypertrophy. Increased renal IGF-I protein content, which is not reflected in messenger RNA (mRNA) levels, suggests that renal IGF-I accumulation is due to sequestration of circulating IGF-I rather than to local synthesis. It has been suggested that IGF-I is trapped in the kidney by IGF binding protein 1 (IGFBP-1). We administered purified human IGFBP-1 (hIGFBP-1) to nondiabetic and diabetic mice as three daily sc injections for 14 days, starting 6 days after induction of streptozotocin diabetes when the animals were overtly diabetic. Markers of early diabetic renal changes (i.e., increased kidney weight, glomerular volume, and albuminuria) coincided with accumulation of renal cortical IGF-I despite decreased mRNA levels in 20-day diabetic mice. Human IGFBP-1 administration had no effect on increased kidney weight or albuminuria in early diabetes, although it abolished renal cortical IGF-I accumulation and glomerular hypertrophy in diabetic mice. Increased IGF-I levels in kidneys of normal mice receiving hIGFBP-1 were not reflected on kidney parameters. IGFBP-1 administration in diabetic mice had only minor effects on diabetic renal changes. Accordingly, these results did not support the hypothesis that IGFBP-1 plays a major role in early renal changes in diabetes

Conservation of core complex subunits shaped the structure and function of photosystem I in the secondary endosymbiont alga Nannochloropsis gaditana

Photosystem I (PSI) is a pigment protein complex catalyzing the light-driven electron transport from plastocyanin to ferredoxin in oxygenic photosynthetic organisms. Several PSI subunits are highly conserved in cyanobacteria, algae and plants, whereas others are distributed differentially in the various organisms. Here we characterized the structural and functional properties of PSI purified from the heterokont alga Nannochloropsis gaditana, showing that it is organized as a supercomplex including a core complex and an outer antenna, as in plants and other eukaryotic algae. Differently from all known organisms, the N. gaditana PSI supercomplex contains five peripheral antenna proteins, identified by proteome analysis as type-R light-harvesting complexes (LHCr4-8). Two antenna subunits are bound in a conserved position, as in PSI in plants, whereas three additional antennae are associated with the core on the other side. This peculiar antenna association correlates with the presence of PsaF/J and the absence of PsaH, G and K in the N. gaditana genome and proteome. Excitation energy transfer in the supercomplex is highly efficient, leading to a very high trapping efficiency as observed in all other PSI eukaryotes, showing that although the supramolecular organization of PSI changed during evolution, fundamental functional properties such as trapping efficiency were maintained

Dose-response effects of a new growth hormone receptor antagonist (B2036-PEG) on circulating, hepatic and renal expression of the growth hormone/insulin-like growth factor system in adult mice

The effects of growth hormone (GH) in regulating the expression of the hepatic and renal GH and insulin-like growth factor (IGF) system were studied by administering a novel GH receptor antagonist (GHRA) (B2036-PEG) at different doses (0, 1.25, 2.5, 5 and 10 mg/kg/day) to mice for 7 days. No differences were observed in the groups with respect to body weight, food consumption or blood glucose. However, a dose-dependent decrease was observed in circulating IGF-I levels and in hepatic and renal IGF-I levels at the highest doses. In contrast, in the 5 and 10 mg/kg/day GHRA groups, circulating and hepatic transcriptional IGF binding protein-3 (IGFBP-3) levels were not modified, likely resulting in a significantly decreased IGF-I/IGFBP-3 ratio. Hepatic GH receptor (GHR) and GH binding protein (GHBP) mRNA levels increased significantly in all GHRA dosage groups. Endogenous circulatory GH levels increased significantly in the 2.5 and 5 mg/kg/day GHRA groups. Remarkably, increased circulating IGFBP-4 and hepatic IGFBP-4 mRNA levels were observed in all GHRA administration groups. Renal GHR and GHBP mRNA levels were not modified by GHRA administration at the highest doses. Also, renal IGFBP-3 mRNA levels remained unchanged in most GHRA administration groups, whereas IGFBP-1, -4 and -5 mRNA levels were significantly increased in the 5 and 10 mg/kg/day GHRA administration groups. In conclusion, the effects of a specific GHR blockade on circulating, hepatic and renal GH/IGF axis reported here, may prove useful in the future clinical use of GHRAs