Case-control study of stroke and the quality of hypertension control in north west England

Objective: To examine the risk of stroke in relation to quality of hypertension control in routine general practice across an entire health district. Design: Population based matched case-control study. Setting: East Lancashire Health District with a participating population of 388,821 aged < or = 80. Subjects: Cases were patients under 80 with their first stroke identified from a population based stroke register between 1 July 1994 and 30 June 1995. For each case two controls matched with the case for age and sex were selected from the same practice register. Hypertension was defined as systolic blood pressure > or = 160 mm Hg or diastolic blood pressure > or = 95 mm Hg, or both, on at least two occasions within any three month period or any history of treatment with antihypertensive drugs. Main outcome measures: Prevalence of hypertension and quality of control of hypertension assessed by using the mean blood pressure recorded before stroke) and odds ratios of stroke (derived from conditional logistic regression). Results: Records of 267 cases and 534 controls were examined; 61% and 42% of these subjects respectively were hypertensive. Compared with non-hypertensive subjects hypertensive patients receiving treatment whose average pre-event systolic blood pressure was controlled to or = 160 mm Hg) or untreated had progressively raised odds ratios of 1.6, 2.2, 3.2, and 3.5 respectively. Results for diastolic pressure were similar; both were independent of initial pressures before treatment. Around 21% of strokes were thus attributable to inadequate control with treatment, or 46 first events yearly per 100,000 population aged 40-79. Conclusions: Risk of stroke was clearly related to quality of control of blood pressure with treatment. In routine practice consistent control of blood pressure to below 150/90 mm Hg seems to be required for optimal stroke prevention

Thermal conductivity of engineered bamboo composites

Here we characterise the thermal properties of engineered bamboo panels produced in Canada, China, and Colombia. Specimens are processed from either Moso or Guadua bamboo into multi-layered panels for use as cladding, flooring or walling. We utilise the transient plane source method to measure their thermal properties and confirm a linear relationship between density and thermal conductivity. Furthermore, we predict the thermal conductivity of a three-phase composite material, as these engineered bamboo products can be described, using micromechanical analysis. This provides important insights on density-thermal conductivity relations in bamboo, and for the first time, enables us to determine the fundamental thermal properties of the bamboo cell wall. Moreover, the density-conductivity relations in bamboo and engineered bamboo products are compared to wood and other engineered wood products. We find that bamboo composites present specific characteristics, for example lower conductivities – particularly at high density – than equivalent timber products. These characteristics are potentially of great interest for low-energy building design. This manuscript fills a gap in existing knowledge on the thermal transport properties of engineered bamboo products, which is critical for both material development and building design.DUS and MCDB thank Mr Robert Cornell (University of Cambridge) for training on thermal conductivity measurement. Special thanks go to Prof Greg Smith and Dr Kate Semple at the University of British Columbia (Department of Wood Science), working on processing of structural bamboo products. This research has been funded by the EPSRC (Grant EP/K023403/1), a Leverhulme Trust Programme Grant, and the Newton Trust.This is the final version of the article. It was first available from Springer via http://dx.doi.org/10.1007/s10853-015-9610-

Design consideration of a multi-function otoacoustic emission measurement system

A new approach for recording otoacoustic emissions (OAEs) is described in the paper. The system is based on a personal computer equipped with INTEL Pentium CPU. A single chip microcomputer INTEL 8096 is developed to be a stimulus generator. Some critical problems and circuit parameters in the design of this system are presented in the paper. The main advantages of the system are (1) it can record three kinds of OAEs which have many clinical applications; (2) it can save raw data for further analysis, as most researchers need; (3) plenty of analysis functions can be developed in this system. With the use of the newly developed system, SOAEs, TEOAEs, and DPOAEs have been successfully measured.published_or_final_versio

Fast tracking of evoked potential variations using correlated scale function designed by multiresolution analysis

Fast tracking of evoked potential variations is of great importance in clinical operation. The paper describes a method whereby an ensemble averaged signal is used as the prototype of the scale function and designs a correlated scale function based on multiresolution analysis. Hence, an effective low pass digital filter having powerful tracking capability is obtained. Results show that the filter designed filters out the noise more effectively than that using general wavelet filtering, and the tracking of the peak of evoked potential is easily obtained.published_or_final_versio

If players are sparse social dilemmas are too: Importance of percolation for evolution of cooperation

Spatial reciprocity is a well known tour de force of cooperation promotion. A thorough understanding of the effects of different population densities is therefore crucial. Here we study the evolution of cooperation in social dilemmas on different interaction graphs with a certain fraction of vacant nodes. We find that sparsity may favor the resolution of social dilemmas, especially if the population density is close to the percolation threshold of the underlying graph. Regardless of the type of the governing social dilemma as well as particularities of the interaction graph, we show that under pairwise imitation the percolation threshold is a universal indicator of how dense the occupancy ought to be for cooperation to be optimally promoted. We also demonstrate that myopic updating, due to the lack of efficient spread of information via imitation, renders the reported mechanism dysfunctional, which in turn further strengthens its foundations.Comment: 6 two-column pages, 5 figures; accepted for publication in Scientific Reports [related work available at http://arxiv.org/abs/1205.0541

Quantum control of hybrid nuclear-electronic qubits

Pulsed magnetic resonance is a wide-reaching technology allowing the quantum state of electronic and nuclear spins to be controlled on the timescale of nanoseconds and microseconds respectively. The time required to flip either dilute electronic or nuclear spins is orders of magnitude shorter than their decoherence times, leading to several schemes for quantum information processing with spin qubits. We investigate instead the novel regime where the eigenstates approximate 50:50 superpositions of the electronic and nuclear spin states forming "hybrid nuclear-electronic" qubits. Here we demonstrate quantum control of these states for the first time, using bismuth-doped silicon, in just 32 ns: this is orders of magnitude faster than previous experiments where pure nuclear states were used. The coherence times of our states are five orders of magnitude longer, reaching 4 ms, and are limited by the naturally-occurring 29Si nuclear spin impurities. There is quantitative agreement between our experiments and no-free-parameter analytical theory for the resonance positions, as well as their relative intensities and relative Rabi oscillation frequencies. In experiments where the slow manipulation of some of the qubits is the rate limiting step, quantum computations would benefit from faster operation in the hybrid regime.Comment: 20 pages, 8 figures, new data and simulation

Fast measurement of SEP for monitoring spinal cord during scoliosis

Recently there has been considerable interest in the use of somatosensory evoked potential (SEP) for monitoring the functional integrity of the spinal cord during surgery such as scoliosis. This paper describes a monitoring system and signal processing algorithms, which consist of an artificial neural network filter and a wavelet signal enhancer developed to enhance the signal-to-noise ratio (SNR) of surface recorded SEP. Our system allows fast detection of change in SEP's peak latency, amplitude and signal waveform, which are the main parameters of interest during intra-operative procedures.published_or_final_versionThe 20th IEEE Engineering in Medicine and Biology Society Conference Proceedings, Hong Kong, China, 29 October - 1 November 1998, v. 4, p. 2239-224

Narrowband Biphotons: Generation, Manipulation, and Applications

In this chapter, we review recent advances in generating narrowband biphotons with long coherence time using spontaneous parametric interaction in monolithic cavity with cluster effect as well as in cold atoms with electromagnetically induced transparency. Engineering and manipulating the temporal waveforms of these long biphotons provide efficient means for controlling light-matter quantum interaction at the single-photon level. We also review recent experiments using temporally long biphotons and single photons.Comment: to appear as a book chapter in a compilation "Engineering the Atom-Photon Interaction" published by Springer in 2015, edited by A. Predojevic and M. W. Mitchel

Formalization of Transform Methods using HOL Light

Transform methods, like Laplace and Fourier, are frequently used for analyzing the dynamical behaviour of engineering and physical systems, based on their transfer function, and frequency response or the solutions of their corresponding differential equations. In this paper, we present an ongoing project, which focuses on the higher-order logic formalization of transform methods using HOL Light theorem prover. In particular, we present the motivation of the formalization, which is followed by the related work. Next, we present the task completed so far while highlighting some of the challenges faced during the formalization. Finally, we present a roadmap to achieve our objectives, the current status and the future goals for this project.Comment: 15 Pages, CICM 201