Controversias sobre el estatuto funcional de algunas entidades glóticas

En el presente artículo se discute sobre el estatuto controvertido de algunas entidades lingüísticas intermedias, precisamente sobre el estatuto funcional de los elementos compositivos de origen grecolatino. Se sostiene la idea que los afijoides representan ciertos elementos compositivos de origen grecolatino susceptibles de contraer relaciones derivacionales con bases derivativas libres (autónomas) en la sincronía y formar derivados afijales. Las unidades léxicas constituidas en exclusividad de elementos compositivos grecolatinos son calificadas como compuestos cultos.L’article reprend en discussion le problème controversé du statut fonctionnel de certaines unités linguistiques intermédiaires, plus précisément le statut des éléments de composition d’origine gréco-latine. On propose l’idée que les affixoïdes represantent des éléments de composition d’origine gréco-latine propres à entrer en rapport de dérivation avec de bases dérivatives libres en synchronie et à former des dérivés affixaux. Les unités lexicales constituées exclusivement des éléments de composition d’origine gréco-latine peuvent être rapportées à la catégorie des composés savants

Controversias sobre el estatuto funcional de algunas entidades glóticas

En el presente artículo se discute sobre el estatuto controvertido de algunas entidades lingüísticas intermedias, precisamente sobre el estatuto funcional de los elementos compositivos de origen grecolatino. Se sostiene la idea que los afijoides representan ciertos elementos compositivos de origen grecolatino susceptibles de contraer relaciones derivacionales con bases derivativas libres (autónomas) en la sincronía y formar derivados afijales. Las unidades léxicas constituidas en exclusividad de elementos compositivos grecolatinos son calificadas como compuestos cultos

The contemporary aspects on diagnosis and treatment of chronic prostatitis

Catedra Urologie şi Nefrologie Chirurgicală USMF “N. Testemiţanu”, Al V-lea Congres de Urologie, Dializă şi Transplant Renal din Republica Moldova cu participare internaţională (1-13 iunie 2011)Summary. Chronic prostatitis is ranked first among the inflammatory diseases of the male urogenital tract, and the third most important disease of the prostate, after benign hyperplasia and cancer. The aim of the work is to study contemporary methods of diagnosis and treatment of chronic prostatitis. The classification of disease proposed by the National Public Health Institute from U.S.A is presented, and diagnostic methods, such as imaging and microbiological are highlighted. It is stressed the importance of a complex treatment with long time antibiotics, alpha adrenoblockers, local complementary therapy and physiotherapy treatment

Histological outcome after conventional testicular sperm extraction vs microsurgical technics in patients with azoospermia

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroduction. The 2021 AUA/ASRM Guidelines on Diagnosis and Treatment of Infertility in Men recommend micro-TESE for men with NOA undergoing sperm retrieval. The 2021 European Association of Urology (EAU) Guidelines on Male Sexual and Reproductive Health recommend conventional or micro-TESE. Aim of study. The study aimed to perform a comparative analysis of the success sperm retrieval rate and histological outcome between tissue samples obtained through conventional and microTESE. Methods and materials. The study included 45 men with a mean age of 33.4±5.6 years. According to the internal protocol, patients with presumed obstructive azoospermia underwent conventional TESE (22 men), while those with non-obstructive azoospermia underwent microTESE (23 men). The criteria for presuming the type of azoospermia were: medical history, testicular volume, hormones and genetic findings. A comparative analysis of the success sperm retrieval rate and histological outcome was conducted in both groups. Results. In the group undergoing classical extraction intervention, the success sperm retrieval rate was 81.8% (18), respectively 18.2% (4) yielding a negative result. Histological analysis revealed normal spermatogenesis in 68.2% (15), reduced spermatogenesis in 22.7% (5), and maturation arrest in 9.1% (2). We observed that 9.1% (2) with reduced spermatogenesis had a negative success rate due to the classical method used. In the group subjected to micro-TESE methods, the success rate was 21.7% (5) versus 78.3% (18) where sperm cells were not identified. Histological examination identified mixed atrophy in 13.6% (3), hypo-spermatogenesis in 8.7% (2), Sertoli cell-only syndrome in 56.5% (13), and tubular fibrosis in 21.2% (5). Conclusion. Both conventional TESE and micro-TESE are effective methods when patients are pre-selected based on the presumed type of azoospermia. For better efficacy, the possibility of switching to the microsurgical method should be considered for patients planned for the classical method. recommend micro-TESE for men with NOA undergoing sperm retri eval. The 2021 European Association of Urology (EAU) Guidelines on Male Sexual and Repr oductive Health recommend conventional or micro-TESE. Aim of study. The study aimed to perform a comparative analysis of the success sperm retrieval rate and histological outcome between tissue samples obt ained through conventional and microTESE. Methods and materials. The study included 45 men with a mean age of 33.4±5.6 years. According to the internal protocol, patients with presumed o bstructive azoospermia underwent conventional TESE (22 men), while those with non-obstruc tive azoospermia underwent microTESE (23 men). The criteria for presuming the type of azo ospermia were: medical history, testicular volume, hormones and genetic findings. A compa rative analysis of the success sperm retrieval rate and histological outcome was conducted in bot h groups. Results. In the group undergoing classical extraction interventio n, the success sperm retrieval rate was 81.8% (18), respectively 18.2% (4) yielding a negative result. Histological analysis revealed normal spermatogenesis in 68.2% (15), reduced spermatogenesis in 22.7% (5), and maturation arrest in 9.1% (2). We observed that 9.1% (2) with reduced spe rmatogenesis had a negative success rate due to the classical method used. In the group subjected to micro-TESE methods, the success rate was 21.7% (5) versus 78.3% (18) where sperm cells were not ide ntified. Histological examination identified mixed atrophy in 13.6% (3), hypo-spermatogen esis in 8.7% (2), Sertoli cell-only syndrome in 56.5% (13), and tubular fibrosis in 21.2% ( 5). Conclusion. Both conventional TESE and micro-TESE are effective me thods when patients are pre-selected based on the presumed type of azoospermia. Fo r better efficacy, the possibility of switching to the microsurgical method should be considere d for patients planned for the classical method

The treatment of erectile dysfunction at the patients with Peyronie diseases. (Case study)

Catedra Urologie şi Nefrologie Chirugicală, IMSP Spitalul Clinic Republican, Al VI-lea Congres de Urologie, Dializă şi Transplant Renal din Republica Moldova cu participare internaţională (21-23 octombrie 2015)Rezumat Maladia Peyroni este una dintre cele mai dificile în practica medicului androlog, în special la pacientul tînăr, şi în asociere cu disfuncţie erectilă. Este prezentată experienţa autorilor în evaluarea multidisciplinară şi aboradrea terapeutică a pacienţilor cu disfuncţie erectilă şi maladia Peyroni. Este argumentată necesitatea administrării zilnice a inhibitorilor de PDE5, în situaţiile cînd curbura peniană este mică.Summary Peyronie's disease is one of the most difficult diseases in medical practice, especially in young patients, and when it is associated with erectile dysfunction. The authors present their experience and multidisciplinary assessment of patients with erectile dysfunction and Peyronie's disease. Daily administration of PDE5 inhibitors is needed in patients with small penile curvature

Testosterone deficiency in men of reproductive age

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. La moment, observăm o adresabilitate tot mai mare a bărbaților tineri (18 – 49 de ani) cu simptome de nivel scăzut de testosteron (T), confirmate prin analize de laborator. Activitatea sexuală redusă, disfuncția erectilă, absența erecțiilor matinale și scăderea dorinței sexuale sunt cele mai predictive și frecvente simptome raportate. Scopul lucrării. Identificarea celor mai importante aspecte în diagnosticul, tratamentul și monitorizarea deficitului de testosteron la bărbații de vârstă fertilă. Material și metode. Analiza literaturii de specialitate utilizând bazele de date PubMed, Hinari, SpringerLink și Scopus, selectând articolele ce elucidează diagnosticul și tratamentul deficitului de testosteron la bărbații de vârstă reproductivă. Rezultate. O treime dintre bărbații infertili sub 50 de ani sunt hipogonadali. Corelarea spermogramei cu nivelul de testosteron a identificat deficitul la 16,7% dintre bărbații cu azoospermie obstructivă, 45% cu azoospermie non-obstructivă, 42,9% cu oligozoospermie și/sau astenozoospermie și 35,3% cu parametri normali ai spermei. În cazurile de afectare a SHBG seric, măsurarea T liber este necesară. Concluzii. Deficitul de testosteron la bărbații de vârstă fertilă este frecvent și asociat cu diverse forme de infertilitate. Terapia de substituție cu testosteron îmbunătățește simptomele hipogonadismului, dar necesită monitorizare pentru a evita efectele negative asupra funcției testiculare. O abordare integrată în diagnostic și tratament este esențială.Introduction. Currently, we observe an increasing number of young men (18 – 49 years) with symptoms characteristic of low testosterone (T) levels, subsequently confirmed by laboratory tests. Reduced sexual activity, erectile dysfunction, absence of morning erections, and decreased sexual desire are the most predictive symptoms for low T levels and the most frequently reported symptoms. Objective of the study. Identification of the most important aspects in the diagnosis, treatment, and monitoring of testosterone deficiency in men of reproductive age. Material and methods: A literature review was conducted using the databases PubMed, Hinari, SpringerLink, and Scopus (Elsevier), selecting articles that elucidate the aspects of diagnosis and treatment of testosterone deficiency in men of reproductive age. Results. It was found that one-third of infertile men under 50 years old are hypogonadal. Correlating sperm analysis results with testosterone levels identified a deficiency in 16.7% of men with obstructive azoospermia, 45% of men with non-obstructive azoospermia, 42.9% of men with oligozoospermia and/or asthenozoospermia, and 35.3% of men with normal sperm parameters. Given that serum SHBG concentration can be affected by liver or kidney disease, thyroid dysfunction, or other endocrine disorders, measuring free T, either calculated or by equilibrium dialysis, is necessary. Conclusions. Testosterone replacement therapy, although effective in addressing most symptoms of hypogonadism, requires careful monitoring to avoid negative effects on endogenous testicular function. An integrated approach in diagnosis and treatment is essential for effectively managing this deficiency

Anti-inflammatory activity of Adenoprosin in nonbacterial prostatitis

Background: The treatment of chronic nonbacterial prostatitis remains an unexplained urology problem. Adenoprosin is a new entomological product containing lipoprotein extract of Lepidopteran insect species. Laboratory studies of the product have shown that it possesses antioxidant, antiproliferative and anti-inflammatory properties. Material and methods: Nonbacterial prostatitis was experimentally modeled on 100 white Wistar rats. Adenoprosin, 150 mg rectal suppositories, was tested against the reference product Vitaprost, 50 mg rectal suppositories and placebo on both the aseptic acute and chronic non-bacterial prostatitis models. In the acute prostatitis model, treatment lasted 7 days and in chronic prostatitis 15 days. The treatment efficacy criteria consisted of assessment of the general condition and histological results. Results: In rats receiving Adenoprosin, the microscopic image of the prostate showed a decrease in the severity of the inflammatory process, in both acute aseptic and chronic nonbacterial prostatitis, manifested by the recovery on the surface of the epithelial cells in the stromal area of the prostate, and decrease in vascular congestion and number of acini with desquamated epithelium. Conclusions: The product of entomological origin Adenoprosin, showed an obvious anti-inflammatory effect in the experimental model of aseptic acute or chronic non-bacterial prostatitis induced on Wistar white rats, similar to the Vitaprost reference product, and significant compared to placebo (p<0.05)

Managementul problemelor sexuale și reproductive la supraviețuitoarele cancerului mamar

Introduction. Breast cancer is the most common form of cancer in women and is a threat to female sexuality, considering the mammary glands’ significance in sexuality, attractiveness, and sexual satisfaction. Female sexual disorders, which involve disturbances in sexual desire, attraction, arousal, orgasm, and genito-pelvic pain, are common among middle-aged breast cancer survivors (BCS). Material and methods. A systematic and structured search of the specialty literature was conducted using PubMed, SCOPUS, EMBASE, and Web of Science databases with keywords such as breast cancer survivors”, “sexual disorders”, and “reproductive health” to find studies relevant to the targeted hypothesis. Works were selected according to the following criteria: full-text articles, publications in English, covering the period 2000-2023. Results. Patients with sexual dysfunctions may benefit from a variety of treatment approaches, such as pharmaceutical, physical, and psychological ones. Studies show that local strategies, such as vaginal estrogens and DHEA, vaginal moisturizers, aqueous lidocaine, vaginal dilators, intravaginal laser, and radiofrequency, as well as psychotherapeutic strategies, such as cognitive-behavioral therapy and couple's therapy based on sexual health, improve sexual function. Conclusions. Identifying and managing sexual dysfunction requires a higher level of awareness, interpersonal interaction, and education among physicians and other health care practitioners. To provide appropriate care and prevent the condition from getting more severe, a systematic assessment of sexual function in BCS patients may be helpful in early diagnosis of sexual disorders.Introducere. Cancerul mamar este cea mai răspândită formă de cancer la femei și reprezintă o amenințare pentru sexualitatea feminină, deoarece marea majoritate a acestora consideră glandele mamare importante în sexualitate, atractivitate și satisfacție sexuală. Tulburările sexuale feminine, care implică perturbări ale dorinței sexuale, atracției, stimulării, orgasmului și durerea genito-pelvină, sunt frecvente la supraviețuitoarele cancerului mamar de vârstă mijlocie. Material și metode. S-a efectuat o cercetare sistemică și structurată a literaturii de specialitate, utilizând bazele de date PubMed, SCOPUS, EMBASE și Web of Science cu cuvintele - cheie „supraviețuitori ai cancerului de sân”, „tulburări sexuale” și „sănătate reproductivă” pentru a găsi studii relevante ipotezei vizate. Au fost selectare lucrări conform următoarelor criterii: articole integrale, publicații în limba engleză, perioada 2000-2023. Rezultate. Pacientele cu disfuncții sexuale pot beneficia de o varietate de abordări terapeutice, cum ar fi cele farmaceutice, fizice și psihologice. Studiile arată că strategiile locale, precum estrogenii vaginali și DHEA, cremele hidratante vaginale, lidocaina apoasă, dilatatoarele vaginale, laserul intravaginal și radiofrecvența, precum și strategiile psihoterapeutice, cum ar fi terapia cognitiv- comportamentală și terapia de cuplu bazată pe sănătatea sexuală, îmbunătățesc funcția sexuală. Concluzii. Identificarea și gestionarea disfuncției sexuale necesită un nivel mai înalt de conștiință, interacțiune interpersonală și educație în rândul medicilor și altor practicieni din domeniul sănătății. Pentru a oferi îngrijiri adecvate și pentru a preveni agravarea afecțiunii, o evaluare sistematică a funcției sexuale pentru supraviețuitoarele cancerului mamar poate fi utilă în diagnosticarea precoce a tulburărilor sexuale