Flexible access to conformationally-locked bicyclic morpholines

A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available key building blocks

Breaking the Curve with CANDELS: A Bayesian Approach to Reveal the Non-Universality of the Dust-Attenuation Law at High Redshift

Dust attenuation affects nearly all observational aspects of galaxy evolution, yet very little is known about the form of the dust-attenuation law in the distant Universe. Here, we model the spectral energy distributions (SEDs) of galaxies at z = 1.5--3 from CANDELS with rest-frame UV to near-IR imaging under different assumptions about the dust law, and compare the amount of inferred attenuated light with the observed infrared (IR) luminosities. Some individual galaxies show strong Bayesian evidence in preference of one dust law over another, and this preference agrees with their observed location on the plane of infrared excess (IRX, $L_{\text{TIR}}/L_{\text{UV}}$) and UV slope ($\beta$). We generalize the shape of the dust law with an empirical model, $A_{\lambda,\delta}=E(B-V)\ k_\lambda\ (\lambda/\lambda_V)^\delta$ where $k_\lambda$ is the dust law of Calzetti et al. (2000), and show that there exists a correlation between the color excess ${E(B-V)}$ and tilt $\delta$ with ${\delta=(0.62\pm0.05)\log(E(B-V))}$+ ${(0.26~\pm~0.02)}$. Galaxies with high color excess have a shallower, starburst-like law, and those with low color excess have a steeper, SMC-like law. Surprisingly, the galaxies in our sample show no correlation between the shape of the dust law and stellar mass, star-formation rate, or $\beta$. The change in the dust law with color excess is consistent with a model where attenuation is caused by by scattering, a mixed star-dust geometry, and/or trends with stellar population age, metallicity, and dust grain size. This rest-frame UV-to-near-IR method shows potential to constrain the dust law at even higher ($z>3$) redshifts.Comment: 20 pages, 18 figures, resubmitted to Ap

The Use of Global System of Mobile Communication (GSM) Among University Students in Malaysia

This study examines the use of the Global System of Mobile Communication (GSM) among University students in Malaysia. The survey approach was used in data collection from a sample population from University Teknologi Malaysia. Fifty undergraduate and post graduate students were sampled at the university library. Results from a multiple regression analysis shows that there is a significant relationship between age, monthly income/allowance of respondents, marital status and rate of calls made and received per day (P<0.05). Gender and mode of study were found to be insignificant (P>0.05).Results from t test equally indicate that the respondents do not vary in their perception on benefits derivable from the use of GSM (t = -.483, P >0.05).Majority of the respondents also agreed that they use GSM to contact their lecturers, course mates, parents, siblings and sending of short message services (SMS).The study conclude with discussions on findings which would be relevant to education policy makers and other interest partie

A metamorphic inorganic framework that can be switched between eight single-crystalline states

The design of highly flexible framework materials requires organic linkers, whereas inorganic materials are more robust but inflexible. Here, by using linkable inorganic rings made up of tungsten oxide (P8W48O184) building blocks, we synthesized an inorganic single crystal material that can undergo at least eight different crystal-to-crystal transformations, with gigantic crystal volume contraction and expansion changes ranging from −2,170 to +1,720 Å3 with no reduction in crystallinity. Not only does this material undergo the largest single crystal-to-single crystal volume transformation thus far reported (to the best of our knowledge), the system also shows conformational flexibility while maintaining robustness over several cycles in the reversible uptake and release of guest molecules switching the crystal between different metamorphic states. This material combines the robustness of inorganic materials with the flexibility of organic frameworks, thereby challenging the notion that flexible materials with robustness are mutually exclusive

In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription

Molecular barcoding technologies that uniquely identify single cells are hampered by limitations in barcode measurement. Readout by sequencing does not preserve the spatial organization of cells in tissues, whereas imaging methods preserve spatial structure but are less sensitive to barcode sequence. Here we introduce a system for image-based readout of short (20-base-pair) DNA barcodes. In this system, called Zombie, phage RNA polymerases transcribe engineered barcodes in fixed cells. The resulting RNA is subsequently detected by fluorescent in situ hybridization. Using competing match and mismatch probes, Zombie can accurately discriminate single-nucleotide differences in the barcodes. This method allows in situ readout of dense combinatorial barcode libraries and single-base mutations produced by CRISPR base editors without requiring barcode expression in live cells. Zombie functions across diverse contexts, including cell culture, chick embryos and adult mouse brain tissue. The ability to sensitively read out compact and diverse DNA barcodes by imaging will facilitate a broad range of barcoding and genomic recording strategies

Pseudoscalar Photon Mixing In A Magnetized Medium

Axions are pseudo-scalar particles, those arise because of breaking of Peccei Queen (PQ) symmetry. Axions have a tree level coupling to two photons. As a consequence there exists a tree level coupling of axion to photon in a magnetic field. However, in an external magnetic field, there exists a new loop induced, axion photon vertex, that gives rise to axion photon coupling. The strength of the tree level axion photon coupling in magnetic field is known to be model dependent. However in a magnetic field, the new loop induced coupling has some interesting features. This note discusses the new axion photon vertex in a magnetized medium and the corrections arising from there. The magnitude of the correction to axion photon coupling, because of magnetized vacuum and matter is estimated in this note. While making this estimate we note that the form of the axion photon vertex is related to the axial polarization tensor. This vertex is shown to satisfy the Ward identity. The coupling is shown to have a momentum dependent piece in it. Astrophysical importance of this extra modification is also pointed out.Comment: Uses Axodraw.st

On the stability of high-speed milling with spindle speed variation

Spindle speed variation is a well-known technique to suppress regenerative machine tool vibrations, but it is usually considered to be effective only for low spindle speeds. In this paper, the effect of spindle speed variation is analyzed in the high-speed domain for spindle speeds corresponding to the first flip (period doubling) and to the first Hopf lobes. The optimal amplitudes and frequencies of the speed modulations are computed using the semidiscre- tization method. It is shown that period doubling chatter can effectively be suppressed by spindle speed variation, although, the technique is not effective for the quasiperiodic chatter above the Hopf lobe. The results are verified by cutting tests. Some special cases are also discussed where the practical behavior of the system differs from the predicted one in some ways. For these cases, it is pointed out that the concept of stability is understood on the scale of the principal period of the system—that is, the speed modulation period for variable spindle speed machining and the tooth passing period for constant spindle speed machining

Non-Thermal X-ray Emission from the Northwestern Rim of the Galactic Supernova Remnant G266.2-1.2 (RX J0852.0-4622)

We present a detailed spatially-resolved spectroscopic analysis of two X-ray observations (with a total integration time of 73280 seconds) made of the luminous northwestern rim complex of the Galactic supernova remnant (SNR) G266.2-1.2 (RX J0852.0-4622) with the Chandra X-ray Observatory. G266.2-1.2 is a member of a class of Galactic SNRs which feature X-ray spectra dominated by non-thermal emission: in the cases of these SNRs, the emission is believed to have a synchrotron origin and studies of the X-ray spectra of these SNRs can lend insights into how SNRs accelerate cosmic-ray particles. The Chandra observations have clearly revealed fine structure in this rim complex and the spectra of these features are dominated by non-thermal emission. We have measured the length scales of the upstream structures at eight positions along the rim and derive lengths of 0.02-0.08 pc (assuming a distance of 750 pc to G266.2-1.2). We have also extracted spectra from seven regions in the rim complex and fit these spectra with such models as a simple power law as well as the synchrotron models SRCUT and SRESC. We have constrained our fits to the latter two models using estimates for the flux densities of these filaments at 1 GHz as determined from radio observations made with the Australia Telescope Compact Array (ATCA). Statistically-acceptable fits to all seven regions are derived using each model: differences in the fit parameters (such as photon index and cutoff frequency) are seen in the different regions, which may indicate variations in shock conditions and the maximum energies of the cosmic-ray electrons accelerated at each region. Finally, we estimate the maximum energy of cosmic-ray electrons accelerated along this rim complex to be approximately 40 TeV. We include a summary of estimated maximum energies for both Galactic SNRs as well as SNRs located in the Large Magellanic Cloud.Comment: 56 Pages, 11 Figures, Accepted for publication in the Astrophysical Journa

Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth.

The plasma membrane represents a critical interface between the internal and extracellular environments, and harbors multiple proteins key receptors and transporters that play important roles in restriction of intracellular infection. We applied plasma membrane profiling, a technique that combines quantitative mass spectrometry with selective cell surface aminooxy-biotinylation, to Bacille Calmette-Guérin (BCG)-infected THP-1 macrophages. We quantified 559 PM proteins in BCG-infected THP-1 cells. One significantly upregulated cell-surface protein was the cholesterol transporter ABCA1. We showed that ABCA1 was upregulated on the macrophage cell-surface following infection with pathogenic mycobacteria and knockdown of ABCA1 resulted in increased mycobacterial survival within macrophages, suggesting that it may be a novel mycobacterial host-restriction factor.Medical Research Council (Clinician Scientist Fellowship), Tsinghua University, Wellcome Trust (Senior Fellowship (Grant ID: 108070/Z/15/Z)), National Institute for Health Research (Academic Clinical Fellowship), China Scholarship CouncilThis is the final version of the article. It first appeared from Frontiers via http://dx.doi.org/10.3389/fmicb.2016.0108

Art therapy after stroke: Evidence and a need for further research

This is the post-print version of the final paper published in The Arts in Psychotherapy. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2012 Elsevier B.V.This review presents available evidence regarding the benefits of art therapy and therapeutic arts interventions for stroke survivors. Whilst available evidence is very limited, it suggests that art therapy may address many of the diverse cognitive, emotional and functional needs of people disabled by stroke. Attention, spatial processing, sequencing and planning seem to improve among those who persist with art therapy. Use of the stroke-affected limb may increase. Several studies report improvements in social interaction, and emotional expression. Most published reports offer single case examples, which are idiographic and illuminating. Nonetheless, the brevity of these reports, the reliance on therapist's own accounts, and uncertainties surrounding case selection make generalization of the findings uncertain. There is a pressing need for multi-method research studies. These could use quantitative standardized scales to explore changes in stroke survivors’ physical and emotional functioning, and qualitative enquiry to gain the insights of stroke survivors concerning the art therapy process. Such research designs might help to establish a better recognized role for art therapy within multidisciplinary stroke rehabilitation programs