The Efficacy of Antibiotics in the Treatment of Chlamydia Trachomatis Infections during Pregnancy. A Systematic Review and a Meta-analysis.

open access journalChlamydia trachomatis infections encountered during pregnancy can lead to many complications for both mother and neonate if left untreated. A systematic review and a meta-analysis were conducted to analyse the efficacy of antibiotic treatment infection during pregnancy that established the most effective antibiotic to treat Chlamydia trachomatis infections during pregnancy. PubMed and Cochrane Library were searched to the end of 2019. Randomised control trials that aligned with inclusion criteria of relevant antibiotics Azithromycin, Erythromycin, Clindamycin and Amoxicillin during Pregnancy was included. A systematic review and meta-analysis were used to calculate pooled (i) success of treatment for each antibiotic in several trials and (ii) the total adverse side effects for each drug encountered in several trials. Randomised controlled trials (RCTs) selected included 1917 pregnant patients with Chlamydia infections, and 851 have completed follow up assessments. Data from three RCTs observed a higher success of treatment for Azithromycin versus Erythromycin, fixed effect model, odds ratio (OR) = 0.67, 95% confidence interval (CI), 0.32-1.80. Data from three RCTs observed a higher success of treatment for Clindamycin versus Erythromycin OR = 2.43 95%, CI:2.00-2.60. Data from two RCTs showed a higher success of treatment for Amoxicillin versus Erythromycin OR = 3.74, 95%, CI:0.68-13.66. Analysis established that Erythromycin resulted in the most adverse side effects. Azithromycin was determined as the most effective antibiotic to treat C. trachomatis infections during pregnancy due to the high success of treatment. Clindamycin is capable of eradicating C. trachomatis infections in pregnancy and can be considered a secondary antibiotic treatment with fewer incidences of adverse side effects and high levels of successful treatment of the infection, however, due to a lack of studies more analysis will be required to confirm the efficacy of Clindamycin

The Paedophile and ‘I’

The year 2004 saw the release of three separate American films which had a focus on paedophilia. The dominant cultural — and legal — response to any and all adult–child sexual relationships is one of intense condemnation. Unexpectedly, however, these films addressed this highly controversial topic in a manner that avoided sensationalism, while simultaneously exposing the complexities of the relationship between the deviant paedophile and the normal sexual self. This article offers an analysis of the differing representations of the paedophile and paedophilic relationships in The Woodsman, Birth and Mysterious Skin. Using a queer theoretical approach, I consider the extent to which these contemporary representations of an otherwise abhorrent sexual form challenge the assumption of and the desire for sexual normality for the viewing subject. In viewing representations of the paedophile, I may hope to see in ‘him’ what I desire to know to be alien to the self, but such a level of sexual comfort is denied me in these films. While none of the films can be said to promote paedophilia, they nevertheless all manage to challenge the distance assumed to exist between this deviant sexual other and the normal sexual self. </jats:p

The effect of certain drugs and hormones on cortisol binding globulin levels in human plasma

Imperial Users onl

To all the bodies I have loved before : the marginalisation of non-homosexual male-male corporeal pleasures in the discourse of gay liberation

In the post-gay liberation era, the body desirous of same-sex sex is presented with the possibility of existing without punishment. Indeed, gay liberation has demanded freedom for this body, insisting that the journey towards enlightened liberation must include a willingness on the part of the body to publicise all of its same-sex sexual desires and pleasures through proud articulation of “I am gay.” This thesis attacks the assumption of freedom assigned within the discourse of gay liberation to both the act of sex and the act of speech. Specifically, I argue against the belief that the body is liberated when it and its pleasures are contained within an identified and identifiable (homo)sexual form.Within the poststructuralist and postmodern contexts, silence has been exposed as a means of repressing the truth. It seeks to deny marginalised bodies the freedom they crave and deserve. Such an interpretation of silence, however, is only one reading among many. I advocate a (re)turn to silence, a (re)casting of it as a mode of resistance to the discipline of the sex-truths established in the culture. In challenging the truths of “man” and “sex” through the construction of a Body without Sex (BwS), I dispute the reality of the homosexual type. The premise of this thesis is that the silence of a BwS offers a space in which the male-d body that engages in same-sex sexualised contact is able to resist the culture’s dictate to be a homosexual. A silencing of anatomical sex and the act of sex disrupts compulsory homosexualisation.This thesis concludes with an application of the concept of a BwS to three male-male relationships in which the participants might experience mutual desires and/or corporeal pleasures. Here, with anticipated controversy, intimate unions between men and boys, “mates” and brothers are removed from the framework of compulsory sexualisation through which the culture demands they must be read. The intensity of the culture’s focus on anatomical sex and the act of sex contain such relationships and the bodies involved within the discipline of the sexual. A BwS aims to resist such discipline through its desire to encourage the body and its pleasures to become other than signifiers of sexual truths