528 research outputs found
SCHROEDER, Susan, Anne J. CRUZ, Cristián ROA-DE-LA-CARRERA, and David E. TAVÁREZ (eds and trans.) — Chimalpahin’s Conquest: A Nahua Historian’s Rewriting of Francisco López de Gómara’s La conquista de México, by...
Analisis Penerapan Sistem Akuntansi Penjualan Kredit Dan Penerimaan Kas Dalam Mendukung Pengendalian Intern Perusahaan (Studi Kasus PT. Smart Tbk Refinery Surabaya)
System of selling credit accounting and system of cash receiving from account receivable is the source of life to achieving company goals. This research on the system of credit sales and cash receipts to support the company internal control. This research was conducted at PT. SMART Tbk Refinery Surabaya. PT. SMART Tbk Refinery Surabaya only selling cooking oil in the form of branded product and trading product on credit. PT. SMART Tbk Refinery Surabaya still has any weakness on system of selling credit accounting and system of cash receiving from account receivable, some of the sales transaction activity that occurred less supportive of the company\u27s internal control. This study aims to provide information to companies about the advantages and weakness of credit sales accounting system and cash receipts that have been applied by the company
The role of genetically defined lamina VII spinal interneurons in generating the locomotor rhythm
Locomotor activity in mammals is generated by neural networks known as central pattern generators (CPGs), which are comprised of interneurons located in the ventral regions of the spinal cord. Recently, molecular genetic characterization of transcription factor expression at early embryonic time points has led to the identification of a handful of genetically-distinct interneuronal populations in the central nervous system. This work has provided valuable insight into the structure and mechanism of function of the locomotor CPG. Of particular interest is the dI6 interneuronal population. These cells originate in the dorsal neural tube, but migrate ventrally during embryogenesis to reside in lamina VII of the postnatal spinal cord. Although it has been suggested that these cells are functionally similar to the neighbouring V0 population and play a role in coordinating left-right alternation during locomotion, dI6 cells have not been physiologically characterized, and as such their role in the locomotor CPG is currently unknown.
In the present work I examine the function of the dI6 cells during fictive locomotion. In part one of this thesis, I describe a novel in vitro fictive locomotor preparation that I developed in order to target neurons located close to the central canal for whole cell recording while leaving the locomotor CPG functionally intact. In the second part of this thesis, this preparation was used to make electrophysiological recordings from dI6 interneurons and investigate their function during fictive locomotion. My results indicate that the dI6 neurons are an electrophysiologically diverse population with the majority oscillating rhythmically during fictive locomotion. Analysis of their intrinsic membrane properties suggest that they are likely involved in generating rhythmic, locomotor-like activity in the mammalian spinal cord
La parte censurada de la Historia de la Provincia de Francisco de Florencia
Before the Jesuit Francisco de Florencia was able to publish the History of the Province (1694) he was forced to remove several chapters from the second book of the first volume. The section that was cut out of his manuscript reviews the errors of ancient theories on the environment of the New World, the greatness of Mexico City before the Spanish conquest, and the natural abundance of New Spain. This document is extremely valuable because it demonstrates how colonial historians were restricted by state censorship in what they were able to publish on America. The transcription of this censored section is preceded by an introduction that provides a brief historical sketch of Florencia\u27s travels in the Old World, the general context in which the History of the Province was penned, and two possible reasons why his chronicle was censore
Infrequency of pure GAD: Impact of psychiatric comorbidity on clinical course
The widespread occurrence of psychiatric comorbidity among patients with generalized anxiety disorder (GAD) has been well documented. However, there is a paucity of studies examining the impact comorbid disorders have on the clinical course of GAD. In this study, 179 patients with GAD at intake, 12 patients with a past history of GAD, and 109 patients who subsequently onset a first episode of GAD during the course of follow-up were followed for 8 years in this naturalistic, prospective study of anxiety disorders. Results indicate that comorbid anxiety, mood, and substance use disorders are very common with GAD and increased during follow-up. For example, 39% of participants with GAD also had a comorbid diagnosis of major depressive disorder at intake and increased to 65% at 4 years and 74% at the 8-year follow-up. Inspection of pure cases of GAD indicated that out of 20 patients with GAD alone at intake, all but 1 went on to develop some comorbidity. Results also indicate that being in episode of comorbid MDD or panic disorder with agoraphobia decreased the probability that a subject would remit from their GAD. The findings highlight the need for such long-term, prospective research since results show that patients with GAD at intake had increasing risk for developing other mental disorders during subsequent follow-ups. Additionally, results of such high comorbidity and the impact of these comorbid disorders on the clinical course of GAD should have a notable impact on research into the treatment of GAD. © 2001 Wiley-Liss, Inc
Potential benefits of ketone therapy as a novel immunometabolic treatment for schizophrenia
Therapeutic ketosis could target the potential bio-energetic pathophysiology of schizophrenia. Ideally, novel treatments also target the possible inflammatory aspects of schizophrenia. Adult mice (n = 30) were treated with ketone ester (KE) or vehicle for 3 days, next LPS- or PBS-injected. Brains were collected the next day. KE significantly attenuated the increased transcription of the pro-inflammatory cytokines Tnf-a, Il-6 and Il-1b, without affecting anti-inflammatory/immunomodulatory cytokines (Il-4, Il-10, Il-11) in whole brain. KE potently dampened neuro-inflammation in this acute inflammation mouse model. Ketone therapy could simultaneously target two possible pathophysiological pathways in schizophrenia. We encourage more research into the immunometabolic potential of therapeutic ketosis in schizophrenia.</p
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