World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention

Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT. Aim: To provide multi-specialty training guidelines for competency, accreditation and certification of centres and physicians in EVT for acute large vessel occlusion strokes. Material and methods: The World Federation for Interventional Stroke Treatment (WIST) consists of experts in the field of endovascular stroke treatment. This interdisciplinary working group developed competency – rather than time-based – guidelines for operator training, taking into consideration trainees’ previous skillsets and experience. Existing training concepts from mostly single specialty organizations were analysed and incorporated. Results: The WIST establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in EVT. WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models. Conclusions: WIST multispecialty guidelines outline competency and quality standards for physicians and centres to perform safe and effective EVT. The role of quality control and quality assurance is highlighted

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention

IntroductionToday, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT.AimTo provide multi-specialty training guidelines for competency, accreditation and certification of centres and physicians in EVT for acute large vessel occlusion strokes.Material and methodsThe World Federation for Interventional Stroke Treatment (WIST) consists of experts in the field of endovascular stroke treatment. This interdisciplinary working group developed competency – rather than time-based – guidelines for operator training, taking into consideration trainees' previous skillsets and experience. Existing training concepts from mostly single specialty organizations were analysed and incorporated.ResultsThe WIST establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in EVT. WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models.ConclusionsWIST multispecialty guidelines outline competency and quality standards for physicians and centres to perform safe and effective EVT. The role of quality control and quality assurance is highlighted

The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the “REGISTRY” cohort from the European Huntington Disease Network (EHDN). In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients). In these Italian patients, the polymorphism is associated with a 6-years earlier disease onset and thus seems to have an aggravating effect. We could specify the role of ATG7 as a genetic modifier for HD particularly in the Italian population. This result affirms the modifying influence of the autophagic pathway on the course of HD, but also suggests population-specific modifying mechanisms in HD pathogenesis

Stratégies d'atténuation et d'intensification de la requête en polonais : comparaison avec le français et l'anglais

International audienc

Designing of circular solutions for tourism industry

Według Światowej Organizacji Turystyki ONZ, Unia Europejska stanowi istotny kierunek podróży. Rozwój turystyki odgrywa więc znaczącą rolę w poprawie koniunktury regionów Wspólnoty Europejskiej. Niestety nie można zapomnieć o jej negatywnych skutkach. Dynamiczny rozwój sektora turystycznego niesie za sobą degradację środowiska naturalnego, rosnące zużycie zasobów naturalnych i wzrost zanieczyszczeń. Rozwiązaniem tych kwestii zajmuje się ekonomia cyrkularna. Jej wdrożenie może pozytywnie wpłynąć na osiągane przez sektor turystyczny zyski, jednocześnie przyczyniając się do zahamowania negatywnych skutków środowiskowych. Artykuł ma na celu zaprezentowanie koncepcji gospodarki obiegu zamkniętego oraz omówienie, na przykładzie hotelu Green Solution House, możliwości implementacji przez obiekty turystyczne rozwiązań cyrkularnych. Inspiracją do napisania artykułu był międzynarodowy projekt CIRTOINNO: Circular economy tools to support innovation in green and blue tourism SMEs.According to the United Nations World Tourism Organisation, the European Union is a major tourism destination. Thus, tourism can play a significant role in the development of European regions. Unfortunately, we cannot forget about its negative effects. The dynamic growth of the tourism sector involves environment degradation, growing consumption of natural resources and rising pollution. Circular economy seems to be an answer to these issues. Its implementation can positively influence tourism profits, simultaneously contributing to limitation of negative environmental effects. This article is aimed at the presentation of the circular economy concept, its practical implementation in tourism, based on the example of the Green Solution House hotel. The article was also inspired by the international project CIRTOINNO: Circular economy tools to support innovation in green and blue tourism SMEs

La traduction automatique de phraséologismes pragmatiques : quelles représentations à travers la diversité formelle et culturelle ?

National audienc

L'expression de l'aspect perfectif / imperfectif dans les systèmes verbaux français et polonais

International audienc

Eléments de description de phraséologismes pragmatiques en vue de la construction d'un dictionnaire pragmatique informatisé français-polonais, polonais-français

International audienc

Je dis ça, je dis rien ; tu m'étonnes ; ja nie mogę ! ; ma się rozumieć : vers un dictionnaire pragmatique informatisé français-polonais, polonais-français

International audienc

Propriétés sémantiques et morpho-syntaxiques des formules de politesse en français et en polonais

International audienc