Gênese do sistema de educação no contexto da teoria da onda de E. Toffler

The purpose of the research is to determine the patterns of development of the system of Russian and foreign education in the context of scientific approaches to the typology of the state. Consider the features of the genesis of education in the wave theory of socio-cultural development of E. Toffler. Methodology: in the process of research, methods of comparative analysis, cyclicity, intersectoral synthesis, theoretical and legal modeling, historical and legal reconstruction, as well as other methods of scientific knowledge were used. Education, as a product of the State and an instrument of State influence on the consciousness and behaviour of the population, is directly dependent on the peculiarities of the State structure and the objectives of which the State is guided in the process of organizational and managerial activity, the methods of interaction of the State with society, local social corporations and individual citizens/subjects.El propósito de la investigación es determinar los patrones de desarrollo del sistema de educación rusa y extranjera en el contexto de los enfoques científicos de la tipología del estado. Considere las características de la génesis de la educación en la teoría ondulatoria del desarrollo sociocultural de E. Toffler. Metodología: en el proceso de investigación se utilizaron métodos de análisis comparativo, ciclicidad, síntesis intersectorial, modelización teórica y jurídica, reconstrucción histórica y jurídica, así como otros métodos de conocimiento científico. La educación, como producto del Estado y como instrumento de influencia del Estado en la conciencia y el comportamiento de la población, depende directamente de las peculiaridades de la estructura del Estado y los objetivos de los cuales se orienta el Estado en el proceso de actividad organizativa y gerencial. , los métodos de interacción del Estado con la sociedad, las corporaciones sociales locales y los ciudadanos / sujetos individuales.O objetivo da pesquisa é determinar os padrões de desenvolvimento do sistema de ensino russo e estrangeiro no contexto das abordagens científicas da tipologia do estado. Considere as características da gênese da educação na teoria ondulatória do desenvolvimento sociocultural de E. Toffler. Metodologia: no processo de pesquisa foram utilizados métodos de análise comparativa, ciclicidade, síntese intersetorial, modelagem teórica e jurídica, reconstrução histórica e jurídica, bem como outros métodos de conhecimento científico. A educação, como produto do Estado e instrumento da influência do Estado na consciência e no comportamento da população, depende diretamente das peculiaridades da estrutura do Estado e dos objetivos dos quais o Estado se orienta no processo de atividade organizacional e gerencial. , os métodos de interação do Estado com a sociedade, as empresas sociais locais e os cidadãos / sujeitos individuais

Effects of chirality on the intracellular localization of binuclear ruthenium(II) polypyridyl complexes

Interest in binuclear ruthenium(II) polypyridyl complexes as luminescent cellular imaging agents and for biomedical applications is increasing rapidly. We have investigated the cellular localization, uptake, and biomolecular interactions of the pure enantiomers of two structural isomers of [μ-bipb(phen)4Ru2]4+ (bipb is bis(imidazo[4,5-f]-1,10-phenanthrolin-2-yl)benzene and phen is 1,10-phenanthroline) using confocal laser scanning microscopy, emission spectroscopy, and linear dichroism. Both complexes display distinct enantiomeric differences in the staining pattern of fixed cells, which are concluded to arise from chiral discrimination in the binding to intracellular components. Uptake of complexes in live cells is efficient and nontoxic at 5 μM, and occurs through an energy-dependent mechanism. No differences in uptake are observed between the structural isomers or the enantiomers, suggesting that the interactions triggering uptake are rather insensitive to structural variations. Altogether, these findings show that the complexes investigated are promising for future applications as cellular imaging probes. In addition, linear dichroism shows that the complexes exhibit DNA-condensing properties, making them interesting as potential gene delivery vectors

Screening for Tuberculosis Infection in Risk Groups in the Adult Population of Moscow

The objective: to evaluate the effectiveness of screening for tuberculosis infection in risk groups among adults using the skin test with tuberculous recombinant allergen (TRA) - Diaskintest®.Subjects and Methods. In 2019-2021, screening for tuberculosis infection in risk groups and in the population with an unknown risk was carried out covering 449,842 people. People aged 18 years and older were examined - patients of the Tuberculosis Control Center, polyclinics and hospitals of medical organizations of the Moscow Health Department. Questionable results were taken into account as positive results of the TRA test.Results. The frequency of positive results of the TRA test in healthy population was as follows: in those contacting pregnant women and newborns - 2.0% (95% CI 1,54-2,10); in decreed groups (workers in food industry, water supply organizations, utilities) - 2,68% (95% CI 2,54-2,82). The situation was different in social risk groups (foreign citizens and stateless persons) - they responded positively to the TRA test in 21,05% (95% CI 20,08-22,06). Most of them arrived to Moscow from states with a high burden of tuberculosis. High-risk groups also include those abusing alcohol and substances; they had positive results in 10,58% (95% CI 8,41-13,24). Among the medical risk groups, the highest rates were observed in those followed up by tuberculosis control services after tuberculosis treatment completion - 39,96% (95% CI 38,31-41,64).Conclusion. Screening in the groups facing the highest risk of developing tuberculosis had a positive effect and once again confirmed the need to screen both resident and migrating population. The immunological skin test with Diaskintest is a reliable tool for examining tuberculosis risk groups