Implicaciones genéticas de nuevos datos de Sr y Nd de rocas intrusivas del Arco Laramide en el Norte de Sonora, México

The Laramide Intrusive Arc constitutes a wide intrusive belt broadly parallel to the actual Sonora coastline. It was formed by the subduction of the Farallon Plate beneath the North-American Plate during the Late Cretaceous-Early Tertiary period. New isotopic data on rocks of this arc show initial 87Sr/86Sr and eNd isotopic values of 0.7066 to 0.7070 and -5 to -6, respectively, for two samples from Bacanora area; as well as 0.7074 to 0.7081 and -3 to -5.5 respectively, for five samples from Cananea, Mariquita and La Caridad areas. Isotopic ages were determined by U/Pb in zircons (95 Ma) and Ar/Ar in potassic feldspar (56 to 71 Ma) from a quartz monzonite porphyry, and by Ar/Ar in potassic feldspar (56 Ma) from another plutonic granodiorite, both from Bacanora. Initial 87Sr/86Sr and eNd values for samples reported in this study suggest that the Laramidic magmas had a large influence from the Proterozoic basement in northeastern Sonora. Four different isotopic zones are proposed for Sonora, according with Sr-Nd data of laramidic rocks and the substratum intruded.El Arco Intrusivo Laramide constituye un amplio cinturón de rocas intrusivas orientado burdamente paralelo a la costa actual de Sonora. Este cinturón se originó por la subducción de la Placa Farallón bajo la Placa de Norteamérica durante el período Cretácico Tardío – Terciario Temprano. Nuevos datos isotópicos en rocas de este arco indican valores iniciales de 87Sr/86Sr y de eNd de 0.7066 a 0.7070 y -5 a -6, respectivamente, para dos muestras del área de Bacanora; así como de 0.7074 a 0.7081 y -3 a -5.5, respectivamente, para cinco muestras de las áreas de Cananea, Mariquita y La Caridad. Se determinaron también edades isotópicas por U/Pb en zircones (95 Ma) y Ar/Ar en feldespato potásico (56 a 71 Ma) para un pórfido de monzonita de cuarzo, y por Ar/Ar en feldespato potásico (56 Ma) para otra granodiorita plutónica, ambas de Bacanora. Los valores iniciales de 87Sr/86Sr y eNd para las muestras reportadas en este estudio, sugieren que los magmas laramídicos tuvieron gran influencia del basamento proterozoico en el noreste de Sonora. Cuatro diferentes zonas isotópicas son propuestas para Sonora, de acuerdo con los datos de Sr-Nd de las rocas laramídicas y el sustrato intrusionado

Planteamiento metodológico para lograr la eficiencia hídrica sustentable. Estudio de caso: unidad habitacional Tepic, Nayarit

El presente trabajo consiste en un estudio acerca de la problemática que enfrentan los conjuntos habitacionales en Tepic Nayarit, para abastecer la creciente demanda de la población. Se parte de cuatro aspectos fundamentales que un sistema de agua potable debe cumplir, de acuerdo a la Comisión Nacional del Agua. Referido a un estudio de caso, en donde se hizo un análisis del contexto en relación con el suministro y presión del agua, análisis del usuario en relación con el consumo de agua, que incluye un monitoreo de gasto actual y otro con dispositivos ahorradores. Al final se establecen escenarios para mejorar el abastecimiento continuo de agua, y para conocer el efecto que tiene la implementación de dispositivos ahorradores. La eficiencia hídrica promovida en estas viviendas ayudará a garantizar el abastecimiento continuo, promover el uso adecuado y consiente del agua, fomentar hábitos de consumo responsable y ayudar a preservar los mantos acuíferos de la ciudad.ITESO, A.C

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes

CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated. To determine the basis for this signaling heterogeneity, we examined the chemokine receptors that signal in a CD38-dependent manner and identified a novel "alternative" chemokine receptor signaling pathway. Similar to the "classical" signaling pathway, the alternative chemokine receptor pathway is activated by G{alpha}i2-containing Gi proteins. However, unlike the classical pathway, the alternative pathway is also dependent on the Gq class of G proteins. We show that G{alpha}q-deficient neutrophils and dendritic cells (DCs) make defective calcium and chemotactic responses upon stimulation with N-formyl methionyl leucyl phenylalanine and CC chemokine ligand (CCL) 3 (neutrophils), or upon stimulation with CCL2, CCL19, CCL21, and CXC chemokine ligand (CXCL) 12 (DCs). In contrast, G{alpha}q-deficient T cell responses to CXCL12 and CCL19 remain intact. Thus, the alternative chemokine receptor pathway controls the migration of only a subset of cells. Regardless, the novel alternative chemokine receptor signaling pathway appears to be critically important for the initiation of inflammatory responses, as G{alpha}q is required for the migration of DCs from the skin to draining lymph nodes after fluorescein isothiocyanate sensitization and the emigration of monocytes from the bone marrow into inflamed skin after contact sensitization

The changing nature of shelf-break exchange revealed by the OOI Pioneer Array

Author Posting. © The Oceanography Society, 2018. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 31, no. 1 (2018): 60–70, doi:10.5670/oceanog.2018.110.Although the continental shelf and slope south of New England have been the subject of recent studies that address decadal-scale warming and interannual variability of water mass properties, it is not well understood how these changes affect shelf-break exchange processes. In recent years, observations of anomalous shelf and slope conditions obtained from the Ocean Observatories Initiative Pioneer Array and other regional observing programs suggest that onshore intrusions of warm, salty waters are becoming more prevalent. Mean cross-shelf transects constructed from Pioneer Array glider observations collected from April 2014 through December 2016 indicate that slope waters have been warmer and saltier. We examine shelf-break exchange events and anomalous onshore intrusions of warm, salty water associated with warm core rings located near the shelf break in spring 2014 and winter 2017 using observations from the Pioneer Array and other sources. We also describe an additional cross-shelf intrusion of ring water in September 2014 to demonstrate that the occurrence of high-salinity waters extending across the continental shelf is rare. Observations from the Pioneer Array and other sources show warm core ring and Gulf Stream water masses intrude onto the continental shelf more frequently and penetrate further onshore than in previous decades.GG, WZ, RT, and MD were supported by the National Science Foundation under grant OCE-1657853. WZ was also supported by grant OCE-1634965. JP is grateful for the support of the Woods Hole Oceanographic Institution Summer Student Fellow Program. AMM was supported by a grant from the MacArthur Foundation. GG and AMM were also supported by a grant from the van Beuren Charitable Foundation for collection and analysis of hydrographic data collected by the CFRF Shelf Research Fleet

Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes

[Background] Neovascularization over dental implants is an imperative requisite to achieve successful osseointegration onto implanted materials. The aim of this study was to investigate the effects on in vitro angiogenesis of anodized 70 nm diameter TiO2 nanotubes (NTs) on Ti6Al4V alloy synthesized and disinfected by means of a novel, facile, antibacterial and cost-effective method using super oxidized water (SOW). We also evaluated the role of the surface roughness and chemical composition of materials of materials on angiogenesis.[Methods] The Ti6Al4V alloy and a commercially pure Ti were anodized using a solution constituted by SOW and fluoride as electrolyte. An acid-etched Ti6Al4V was evaluated to compare the effect of micro-surface roughness. Mirror-polished materials were used as control. Morphology, roughness, chemistry and wettability were assessed by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy, atomic force microscopy, energy dispersive X-ray spectroscopy (EDX) and using a professional digital camera. Bovine coronary artery endothelial cells (BCAECs) were seeded over the experimental surfaces for several incubation times. Cellular adhesion, proliferation and monolayer formation were evaluated by means of SEM. BCAEC viability, actin stress fibers and vinculin cellular organization, as well as the angiogenic receptors vascular endothelial growth factor 2 (VEGFR2) and endothelial nitric oxide synthase (eNOS) were measured using fluorescence microscopy.[Results] The anodization process significantly increased the roughness, wettability and thickness of the oxidized coating. EDX analysis demonstrated an increased oxygen (O) and decreased carbon (C) content on the NTs of both materials. Endothelial behavior was solidly supported and improved by the NTs (without significant differences between Ti and alloy), showing that endothelial viability, adhesion, proliferation, actin arrangement with vinculin expression and monolayer development were evidently stimulated on the nanostructured surface, also leading to increased activation of VEGFR2 and eNOS on Ti6Al4V-NTs compared to the control Ti6Al4V alloy. Although the rougher alloy promoted BCAECs viability and proliferation, filopodia formation was poor.[Conclusion] The in vitro results suggest that 70 nm diameter NTs manufactured by anodization and cleaned using SOW promotes in vitro endothelial activity, which may improve in vivo angiogenesis supporting a faster clinical osseointegration process.The authors wish to thank to the Program Number UABC-PTC-469 from PRODEP and Program Number 2058 of UABC for financial support. They are also grateful to CONACYT, Mexico, for scholarship 348737-114359.Peer reviewe

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article

Modelo de formación de los yacimientos estratoligados de Cu en lechos rojos de Las Vigas (Chihuahua, México)

Peer ReviewedPostprint (published version

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG. At genome-wide significance level, only ABCA1 harbors associations to both diseases. Here, we investigated the genetic architecture of POAG and AMD using genome-wide array data. We estimated the heritability for POAG (h2 g = 0.42 ± 0.09) and AMD (h2 g = 0.71 ± 0.08). Removing known loci for POAG and AMD decreased the h2 g estimates to 0.36 and 0.24, respectively. There was evidence for a positive genetic correlation between POAG and AMD (rg = 0.47 ± 0.25) which remained after removing known loci (rg = 0.64 ± 0.31). We also found that the genetic correlation between sexes for POAG was likely to be less than 1 (rg = 0.33 ± 0.24), suggesting that differences of prevalence among genders may be partly due to heritable factors

ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure

Primary open-angle glaucoma (POAG) is a blinding disease. Two important risk factors for this disease are a positive family history and elevated intraocular pressure (IOP), which is also highly heritable. Genes found to date associated with IOP and POAG are ABCA1, CAV1/CAV2, GAS7 and TMCO1. However, these genes explain only a small part of the heritability of IOP and POAG.We performed a genome-wide association study of IOP in the population-based RotterdamStudy I and Rotterdam Study II using single nucleotide polymorphisms (SNPs) imputed to 1000 Genomes. In this discovery cohort (n = 8105), we identified a newlocus associated with IOP. The most significantly associated SNPwas rs58073046 (ß = 0.44, P-value = 1.87 × 10-8, minor allele frequency = 0.12), within the gene ARHGEF12. Independent replication in five population-based studies (n = 7471) resulted in an effect size in the same direction that was significantly associated (ß = 0.16, P-value = 0.04). The SNP was also significantly associated with POAG in two independent case-control studies [n = 1225 cases and n = 4117 controls; odds ratio (OR) = 1.53, P-value = 1.99 × 10-8], especially with high-tension glaucoma (OR = 1.66, P-value = 2.81 × 10-9; for normal-tension glaucoma OR = 1.29, P-value = 4.23 × 10-2). ARHGEF12 plays an important role in the RhoA/RhoA kinase pathway, which has been implicated in IOP regulation. Furthermore, it binds to ABCA1 and links the ABCA1, CAV1/CAV2 and GAS7 pathway to Mendelian POAG genes (MYOC, OPTN, WDR36). In conclusion, this study identified a novel association between IOP and ARHGEF12

El discurso de la Guerra Sucia en su relación con el neoliberalismo en México

This paper presents a critical review of the discourse emanating from the social movements during the Dirty War (1964-1982), in its relation with the neoliberal discourse in Mexico. Based on a post-structuralist approach tied to the discourse theory, the effects of the dispute over the values that sustained the Mexican state discourse since the revolution as a social order are analyzed. From a journey through economic models and their crises in the second half of the 20th century, it is proposed that the dissident discourse distorted the sense of revolutionary values, and that this was sutured by the neoliberal discourse.En este texto se expone una revisión crítica del discurso emanado de los movimientos sociales durante la Guerra Sucia (1964-1982), en su relación con el discurso neoliberal en México. A partir de un enfoque posestructuralista anudado a la teoría del discurso, se analizan los efectos de la disputa por los valores que sostenían el discurso estatal mexicano desde la revolución como ordenamiento de lo social. Desde un recorrido por los modelos económicos y sus crisis en la segunda mitad del siglo XX, se propone que el discurso disidente dislocó el sentido de los valores revolucionarios, y que este fue suturado por el discurso neoliberal