An assessment of twilight airglow inversion procedures using atmosphere explorer observations

The aim of this research project was to test and truth some recently developed methods for recovering thermospheric oxygen atom densities and thermospheric temperatures from ground-based observations of the 7320 A O(+)((sup 2)D - (sup 2)P) twilight air glow emission. The research plan was to use twilight observations made by the Visible Airglow Experiment (VAE) on the Atmosphere Explorer 'E' satellite as proxy ground based twilight observations. These observations were to be processed using the twilight inversion procedures, and the recovered oxygen atom densities and thermospheric temperatures were then to be examined to see how they compared with the densities and temperatures that were measured by the Open Source Mass Spectrometer and the Neutral Atmosphere Temperature Experiment on the satellite

A structural and thermal packaging approach for power processing units for 30-cm ion thrusters

Solar Electric Propulsion (SEP) is currently being studied for possible use in a number of near earth and planetary missions. The thruster subsystem for these missions would consist of 30 centimeter ion thrusters with Power Processor Units (PPU) clustered in assemblies of from two to ten units. A preliminary design study of the electronic packaging of the PPU has been completed at Lewis Research Center of NASA. This study evaluates designs meeting the competing requirements of low system weight and overall mission flexibility. These requirements are evaluated regarding structural and thermal design, electrical efficiency, and integration of the electrical circuits into a functional PPU layout

Feasibility study of a long duration balloon flight with NASA/GSFC and Soviet Space Agency Gamma Ray Spectrometers

A feasibility study of conducting a joint NASA/GSFC and Soviet Space Agency long duration balloon flight at the Antarctic in Jan. 1993 is reported. The objective of the mission is the verification and calibration of gamma ray and neutron remote sensing instruments which can be used to obtain geochemical maps of the surface of planetary bodies. The gamma ray instruments in question are the GRAD and the Soviet Phobos prototype. The neutron detectors are supplied by Los Alamos National Laboratory and the Soviet Phobos prototype. These are to be carried aboard a gondola that supplies the data and supplies the power for the period of up to two weeks

The effect of competition on the control of invading plant pathogens

1. New invading pathogen strains must compete with endemic pathogen strains to emerge and spread. As disease control measures are often non-specific, i.e. they do not distinguish between strains, applying control not only affects the invading pathogen strain but the endemic as well. We hypothesise that the control of the invasive strain could be compromised due to the non-specific nature of the control. 2. A spatially-explicit model, describing the East African cassava mosaic virus-Uganda strain (EACMV-UG) outbreak, is used to evaluate methods of controlling both disease incidence and spread of invading pathogen strains in pathosystems with and without an endemic pathogen strain present. 3. We find that while many newly introduced or intensified control measures (such as resistant cultivars or roguing) decrease the expected incidence, they have the unintended consequence of increasing, or at least not reducing, the speed with which the invasive pathogen spreads geographically. We identify which controls cause this effect and methods in which these controls may be applied to prevent it. 4. We found that the spatial spread of the invading strain is chiefly governed by the incidence at the wave front. Control can therefore be applied, or intensified, once the wave front has passed without increasing the pathogen’s rate of spread. 5. When trade of planting material occurs, it is possible that the planting material is already infected. The only forms of control in this study that reduces the speed of geographic spread, regardless of the presence of an endemic strain, are those that reduce the amount of trade and the distance over which trade takes place. 6. Synthesis and applications. Imposing trade restrictions before the epidemic has reached a given area and increasing other control methods only once the wave front has passed is the most effective way of both slowing down spread and controlling incidence when the presence of an endemic strain is unknow

Novel modeling of task versus rest brain state predictability using a dynamic time warping spectrum: comparisons and contrasts with other standard measures of brain dynamics

Dynamic time warping, or DTW, is a powerful and domain-general sequence alignment method for computing a similarity measure. Such dynamic programming-based techniques like DTW are now the backbone and driver of most bioinformatics methods and discoveries. In neuroscience it has had far less use, though this has begun to change. We wanted to explore new ways of applying DTW, not simply as a measure with which to cluster or compare similarity between features but in a conceptually different way. We have used DTW to provide a more interpretable spectral description of the data, compared to standard approaches such as the Fourier and related transforms. The DTW approach and standard discrete Fourier transform (DFT) are assessed against benchmark measures of neural dynamics. These include EEG microstates, EEG avalanches, and the sum squared error (SSE) from a multilayer perceptron (MLP) prediction of the EEG time series, and simultaneously acquired FMRI BOLD signal. We explored the relationships between these variables of interest in an EEG-FMRI dataset acquired during a standard cognitive task, which allowed us to explore how DTW differentially performs in different task settings. We found that despite strong correlations between DTW and DFT-spectra, DTW was a better predictor for almost every measure of brain dynamics. Using these DTW measures, we show that predictability is almost always higher in task than in rest states, which is consistent to other theoretical and empirical findings, providing additional evidence for the utility of the DTW approach

Analysis of ISER 2008-2009 Survey Data

In September 2008, the superintendent of the Anchorage School District and the mayor of Anchorage sent a letter to the governor of Alaska, reporting what they thought might be an influx of students into Anchorage from rural communities. Enrollment in the school district was higher than expected, and it coincided with the largest-ever Alaska Permanent Fund dividend and with a one-time payment of $1,200 the state made per person, to help offset high energy costs. Researchers at the Institute of Social and Economic Research (ISER) at UAA have a longstanding interest in migration patterns in Alaska and the Arctic, and they saw the increased enrollment in Anchorage schools as a potential opportunity to better understand: • If rural Alaskans are moving to Anchorage • Where they are coming from • Why they are moving So with the cooperation of the Anchorage School District, ISER conducted a survey of the parents or guardians of students who had enrolled in Anchorage in the 2007-2008 or 2008-2009 school years and who had transferred in from other Alaska school districts. Besides finding out where students were coming from—and why—another purpose of the study was to provide the Anchorage School District and the Municipality of Anchorage with information about what they could do to help students and families who are new to the city. To our knowledge, this may be the first survey ever conducted to find out why people move to Anchorage from other areas of Alaska.University of Alaska Foundation. BP-Conoco Phillips Charter AgreementExecutive Summary / Introduction / Methods / Where are Alaskan's Moving From? / Organization of Survey Findings / Migration Patterns / Who is Moving? / Challenges and Transitions / Conclusions and Recommendations / References / Appendix A. Survey For

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal.

Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the Golgi. Norwalk virus nonstructural protein p22 contains a YXΦESDG motif that mimics a di-acidic ER export signal in both sequence and function. However, unlike normal ER export signals, the ER export signal mimic of p22 is necessary for apparent inhibition of normal COPII vesicle trafficking, which leads to Golgi disassembly and antagonism of Golgi-dependent cellular protein secretion. This is the first reported function for p22. Disassembly of the Golgi apparatus was also observed in cells replicating Norwalk virus, which may contribute to pathogenesis by interfering with cellular processes that are dependent on an intact secretory pathway. These results indicate that the ER export signal mimic is critical to the antagonistic function of p22, shown herein to be a novel antagonist of ER/Golgi trafficking. This unique and well-conserved human norovirus motif is therefore an appealing target for antiviral drug development

After Broadband: A Study of Organizational Use of Broadband in Southwest Alaska

The purpose of this research was to gain a preliminary understanding of how organizations including large and small businesses, Native corporations and organizations, and local and regional governments are using broadband that is now available in much of southwest Alaska. To learn about community access to broadband, interviews were also conducted with library and school staff in communities where broadband had been installed under the OWL (Online with Libraries) program. Further, the study identifies research from other sources that could help to predict what socio-economic impacts the availability and adoption of broadband may have in rural Alaska. Financial institutions use online connections for teller services and credit and debit card processing, and stated that more people in rural communities now have debit cards that they can use for online purchases and bill paying. Large retailers use online services for payroll, for pointof-sale (POS) transactions, and online ordering. Seafood processors rely heavily on connectivity with their head offices (generally in the lower 48) for administrative services including payroll, accounting, shipping and receiving, purchasing, and ERP (enterprise resource planning), and access data base software to track fish tickets. Seafood processors also provide Internet access for their employees, most of whom are seasonal and from other states or countries. Tourism businesses use broadband for online reservation systems and for guests, who increasingly demand connectivity even for remote vacations. Village corporations and tribal councils use online services to help their residents obtain hunting and fishing licenses and fishing permits, to learn about funding opportunities, and to file reports on grants. Local Governments connect online for interoffice communications and for payroll and other administrative functions. Other online applications and services include providing remote desktop access from other agency sites, use of online tools for land management and mapping, training including webinars for workforce development, and providing access to social services for clients. An economic development organization sends newsletters to communities electronically and packets of documents to its board members rather than relying on fax or courier. Websites are important for tourism-related businesses to advertise and promote their businesses and for nonprofits and local governments to provide information about their services. 5 Broadband now plays many roles in rural education. Most students are required to use the Internet for class assignments. High school students can connect to classes in advanced subjects in other communities, and may complete online courses for college credit. Libraries remain important locations for community access, with residents going online to connect with friends on Facebook, as well as to download content for e-books, file income tax, and apply for jobs and government benefits. School and library Wi-Fi provides access inside and near the buildings for residents with smartphones. Despite enthusiasm for broadband and the adoption of many broadband-based applications and services, most organizations interviewed identified problems with broadband, particularly with the pricing, stating that the terrestrial broadband network is too costly for them to take full advantage of online services and applications. While the scope of this study was too limited to estimate long-term benefits, it found that broadband is highly valued and increasingly important to businesses and nonprofit organizations and local governments in southwest Alaska. Broadband helps businesses to be more efficient in their operations and to extend their reach to new customers and suppliers. It also helps to improve the effectiveness of public sector services such as those provided by borough and city governments and extends access to education and training. Broadband is also likely to be an important component of strategies to develop ecotourism and other ecosystem services.Support for this research came from Connect Alaska with funding from the National Telecommunications and Information Administration (NTIA) for the work of the State of Alaska Broadband Task Force, with additional support from GCI.Executive Summary / Introduction / Research Methodology / Technologies and Technical Support / Broadband Applications / Education and Community Access / Health Care / Benefits of Broadband in Southwest Alaska / Problems and Limitations / Potential Long-Term Social and Economic Impacts / Conclusions and Recommendations / Referemce

Gated metabolic myocardial imaging, a surrogate for dual perfusion-metabolism imaging by positron emission tomography

Acknowledgments The authors are grateful for the help from Dr H Ali and Dr A Dawson. Funding: This study was performed using a research grant from the Aberdeen Royal Hospitals Trust's Endowment Fund, with further support from the Department of Medical Physics at the University of Aberdeen, for which the authors express their gratitude.Peer reviewedPublisher PD

Spatially and Temporally Explicit Energy System Modelling to Support the Transition to a Low Carbon Energy Infrastructure – Case Study for Wind Energy in the UK

Renewable energy sources and electricity demand vary with time and space and the energy system is constrained by the location of the current infrastructure in place. The transitioning to a low carbon energy society can be facilitated by combining long term planning of infrastructure with taking spatial and temporal characteristics of the energy system into account. There is a lack of studies addressing this systemic view. We soft-link two models in order to analyse long term investment decisions in generation, transmission and storage capacities and the effects of short-term fluctuation of renewable supply: The national energy system model UKTM (UK TIMES model) and a dispatch model. The modelling approach combines the benefits of two models: an energy system model to analyse decarbonisation pathways and a power dispatch model that can evaluate the technical feasibility of those pathways and the impact of intermittent renewable energy sources on the power market. Results give us the technical feasibility of the UKTM solution from 2010 until 2050. This allows us to determine lower bounds of flexible elements and feeding them back in an iterative process (e.g. storage, demand side control, balancing). We apply the methodology to study the long-term investments of wind infrastructure in the United Kingdom