Diquark in Nona-quark States

We study the nonaquark states $S^0(3115)$ and $S^+(3140)$ which are reported by KEK-PS (Phys.Lett. B597 (2004) 236; nucl-ex/0310018) by means of the quark model with diquark correlation. The nonaquark states form $\bf{1},\bf{8},\bf{10},\bar{\bf{10}},\bf{27},\bar{\bf{35}}$ SU(3) multiplets. The flavor wave functions of all the nonaquark states are constructed through the standard tensor technique. The mass spectrum is studied by using Gell-Mann-Okubo mass formula. Some nonaquark mass sum rules are obtained. We further investigate the decay of $S^0(3115)$ and $S^+(3140)$ under the assumption of "fall-apart" mechanism. It has been found that the main decay mode is $\Sigma NN$ rather than $\Lambda NN$ which is consistent with experiment. Also we have uniquely determine the flavor wave function of $S^0(3115)$ which belong to $\bf{27}$-plet with the quantum number $Y=2,I=1,I_z=-1$. Whereas the exotic states $S^+(3140)$ can belong to either $\bf{27}$-plet or $\bar{\bf{35}}$-plet. In the exact $SU(3)^{flavor}\times SU(3)^{color}\times SU(2)^{spin}$ limit, both $S^0(3115)$ and $S^+(3140)$ belong to ${\bf 27}$-plet with negative parity. We predict that its flavor structure can be determined by measuring the branch fractions of its decay channels. The experiments to check this prediction are expected.Comment: 23 pages, 8 figures, to appear in Phys. Rev.

Development and construction of China

Libraries in China's higher education institutions have been developing in keeping pace with the flourishing development of China's higher education. This article aims to make an introduction to the construction of China's higher education libraries, especially the recent three decades' achievements since China's reform and opening-up in 1978. In this article, the authors draw a general picture of the development of libraries in China's higher education institutions, covering such eight aspects as management, types and positioning, organizational structure and personnel, expenditure and buildings, reader service, building and sharing of resources as well as automation system.</p

Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration

The biophysical microenvironment of the tumor site has significant impact on breast cancer progression and metastasis. The importance of altered mechanotransduction in cancerous tissue has been documented, yet its role in the regulation of cellular metabolism and the potential link between cellular energy and cell migration remain poorly understood. In this study, we investigated the role of mechanotransduction in AMP-activated protein kinase (AMPK) activation in breast cancer cells in response to interstitial fluid flow (IFF). Additionally, we explored the involvement of AMPK in breast cancer cell migration. IFF was applied to the 3D cell-matrix construct. The subcellular signaling activity of Src, FAK, and AMPK was visualized in real-time using fluorescent resonance energy transfer (FRET). We observed that breast cancer cells (MDA-MB-231) are more sensitive to IFF than normal epithelial cells (MCF-10A). AMPK was activated at the mitochondria of MDA-MB-231 cells by IFF, but not in other subcellular compartments (i.e., cytosol, plasma membrane, and nucleus). The inhibition of FAK or Src abolished flow-induced AMPK activation in the mitochondria of MDA-MB-231 cells. We also observed that global AMPK activation reduced MDA-MB-231 cell migration. Interestingly, specific AMPK inhibition in the mitochondria reduced cell migration and blocked flow-induced cell migration. Our results suggest the linkage of FAK/Src and mitochondria-specific AMPK in mechanotransduction and the differential role of AMPK in breast cancer cell migration depending on its subcellular compartment-specific activation