The FORS Deep Field: Field selection, photometric observations and photometric catalog

The FORS Deep Field project is a multi-colour, multi-object spectroscopic investigation of an approx. 7 times 7 region near the south galactic pole based mostly on observations carried out with the FORS instruments attached to the VLT telescopes. It includes the QSO Q 0103-260 (z = 3.36). The goal of this study is to improve our understanding of the formation and evolution of galaxies in the young Universe. In this paper the field selection, the photometric observations, and the data reduction are described. The source detection and photometry of objects in the FORS Deep Field is discussed in detail. A combined B and I selected UBgRIJKs photometric catalog of 8753 objects in the FDF is presented and its properties are briefly discussed. The formal 50% completeness limits for point sources, derived from the co-added images, are 25.64, 27.69, 26.86, 26.68, 26.37, 23.60 and 21.57 in U, B, g, R, I, J and Ks (Vega-system), respectively. A comparison of the number counts in the FORS Deep Field to those derived in other deep field surveys shows very good agreement.Comment: 15 pages, 11 figures (included), accepted for publication in A&

Ironing out the details: Untangling dietary iron and genetic background in diabetes

The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health. Genetic variation between individuals confers differences in metabolism, which directly impacts response to diet. Most studies attempting to identify genetic risk factors in disease fail to incorporate dietary components, and thus are ill-equipped to capture the breadth of the genome’s impact on metabolism. Understanding how genetic background interacts with nutrients holds the key to predicting and preventing metabolic diseases through the implementation of personalized nutrition. Dysregulation of iron homeostasis is associated with type-II diabetes, but the link between dietary iron and metabolic dysfunction is poorly defined. High iron burden in adipose tissue induces insulin resistance, but the mechanisms underlying adipose iron accumulation remain unknown. Hepcidin controls dietary iron absorption and distribution in metabolic tissues, but it is unknown whether genetic variation influencing hepcidin expression modifies susceptibility to dietary iron-induced insulin resistance. This review highlights discoveries concerning the axis of iron homeostasis and adipose function and suggests that genetic variation underlying dietary iron metabolism is an understudied component of metabolic disease

Our Apples are Healthier than Your Apples: Deciphering the Healthiness Bias for Domestic and Foreign Products

This study extends previous research by exploring perceptions of healthiness in the international food marketplace. To this end, it aims to fill an important gap by shedding light on the role of country of origin in shaping perceptions of healthiness. The authors provide evidence that domestic and foreign food products elicit different perceptions of healthiness. Consumers choose domestic products because they perceive them as healthier and more natural. The effect holds across different samples and product categories (apples, tomatoes, bread, and yogurt). However, this healthiness bias vanishes when products are presented as posing health risks and when products are introduced with a dual identity (i.e., both foreign and domestic). Researching these health-related effects helps provide a better understanding of consumer attitudes toward domestic- versus foreign-made food products

El tecnotrabajo de trabajo

Este artículo realiza un tratamiento de las nuevas tecnologías en las relaciones laborales estudiando la utilización de las herramientas telemáticas como canales de comunicación en las fases de nacimiento, desarrollo y extinción del contrato de trabajo. En este sentido, identifica la contratación electrónica con el término "Tecnocontrato de trabajo" no sólo por la utilización de la `forma electrónica" en el intercambio de las declaraciones de voluntades de un contrato de trabajo dotando de validez al consentimiento en el periodo deformación sino también y, en general, por las comunicaciones telemáticas entre las partes laborales durante la vigencia del contrato de trabajo.________________________________This work deals with the use of new technologies in labour relations and the utilizatión of "e-tools" as means of comunication in the diferent phases of a labour contract: origin, duration and termination. We use the term "tech-contract" to identify contracts signed using an "e form ". In this type of contract, e-tools are used for the statements of will of the parties involved and the exchange of communications between these parties while the contract is valid

The Global Ant Genomics Alliance (GAGA)

Peer reviewe

El tecnotrabajo de trabajo

Este artículo realiza un tratamiento de las nuevas tecnologías en las relaciones laborales estudiando la utilización de las herramientas telemáticas como canales de comunicación en las fases de nacimiento, desarrollo y extinción del contrato de trabajo. En este sentido, identifica la contratación electrónica con el término "Tecnocontrato de trabajo" no sólo por la utilización de la `forma electrónica" en el intercambio de las declaraciones de voluntades de un contrato de trabajo dotando de validez al consentimiento en el periodo deformación sino también y, en general, por las comunicaciones telemáticas entre las partes laborales durante la vigencia del contrato de trabajo.This work deals with the use of new technologies in labour relations and the utilizatión of "e-tools" as means of comunication in the diferent phases of a labour contract: origin, duration and termination. We use the term "tech-contract" to identify contracts signed using an "e form ". In this type of contract, e-tools are used for the statements of will of the parties involved and the exchange of communications between these parties while the contract is valid

Current and Future Issues in the Development of Spinal Agents for the Management of Pain.

Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal dorsal horn and this output informs the brain as to the peripheral environment. This encoding process is subject to strong upregulation resulting in hyperesthetic states and downregulation reducing the ongoing processing of nociceptive stimuli reversing the hyperesthesia and pain processing. The present review addresses the biology of spinal nociceptive processing as relevant to the effects of intrathecally-delivered drugs in altering pain processing following acute stimulation, tissue inflammation/injury and nerve injury. The review covers i) the major classes of spinal agents currently employed as intrathecal analgesics (opioid agonists, alpha 2 agonists; sodium channel blockers; calcium channel blockers; NMDA blockers; GABA A/B agonists; COX inhibitors; ii) ongoing developments in the pharmacology of spinal therapeutics focusing on less studied agents/targets (cholinesterase inhibition; Adenosine agonists; iii) novel intrathecal targeting methodologies including gene-based approaches (viral vectors, plasmids, interfering RNAs); antisense, and toxins (botulinum toxins; resniferatoxin, substance P Saporin); and iv) issues relevant to intrathecal drug delivery (neuraxial drug distribution), infusate delivery profile, drug dosing, formulation and principals involved in the preclinical evaluation of intrathecal drug safety