205 research outputs found

    Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC)

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    <p>Synthetic and naturally occurring substances present in food and feed, together with their possible breakdown or reaction products, represent a large number of substances, many of which require risk assessment. EFSA’s Scientific Committee was requested to evaluate the threshold of toxicological concern (TTC) approach as a tool for providing scientific advice about possible human health risks from low level exposures, its applicability to EFSA’s work, and to advise on any additional data that might be needed to strengthen the underlying basis of the TTC approach. The Scientific Committee examined the published literature on the TTC approach, undertook its own analyses and commissioned an <em>in silico </em>investigation of the databases underpinning the TTC approach. The Scientific Committee concluded that the TTC approach can be recommended as a useful screening tool either for priority setting or for deciding whether exposure to a substance is so low that the probability of adverse health effects is low and that no further data are necessary. The following human exposure threshold values are sufficiently conservative to be used in EFSA’s work; 0.15 μg/person per day for substances with a structural alert for genotoxicity, 18 μg/person per day for organophosphate and carbamate substances with anti-cholinesterase activity, 90 μg/person per day for Cramer Class III and Cramer Class II substances, and 1800 μg/person per day for Cramer Class I substances, but for application to all groups in the population, these values should be expressed in terms of body weight, i.e. 0.0025, 0.3, 1.5 and 30 μg/kg body weight per day, respectively. Use of the TTC approach for infants under the age of 6 months, with immature metabolic and excretory systems, should be considered on a case-by-case basis. The Committee defined a number of exclusion categories of substances for which the TTC approach would not be used.</p&gt

    Aiding eco-labelling process and its implementation: environmental impact assessment methodology to define product category rules for canned anchovies

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    To be able to fulfil high market expectations for a number of practical applications, Environmental Product Declarations (EPDs) have to meet and comply with specific and strict methodological prerequisites. These expectations include the possibility to add up Life Cycle Assessment (LCA)-based information in the supply chain and to compare different EPDs. To achieve this goal, common and harmonized calculation rules have to be established, the so-called Product Category Rules (PCRs), which set the overall LCA calculation rules to create EPDs. This document provides PCRs for the assessment of the environmental performance of canned anchovies in Cantabria Region based on an Environmental Sustainability Assessment (ESA) method. This method uses two main variables: the natural resources sustainability (NRS) and the environmental burdens sustainability (EBS). To reduce the complexity of ESA and facilitate the decision-making process, all variables are normalized and weighted to obtain two global dimensionless indexes: resource consumption (X1) and environmental burdens (X2). • This paper sets the PCRs adapted to the Cantabrian canned anchovies.• ESA method facilitates the product comparison and the decision-making process.• This paper stablishes all the steps that an EPD should include within the PCRs of Cantabrian canned anchovies.Authors thank to Ministry of Economy and Competitiveness of Spanish Government for the financial support through the project called GeSAC-Conserva: Sustainable Management of the Cantabrian Anchovies (CTM2013-43539-R). Jara Laso also thanks to the Ministry of Economy and Competitiveness of Spanish Government for the financial support through the research fellowship BES-2014-069368. MethodsX thanks the reviewers of this article for taking the time to provide valuable feedback

    Model comparison and quantification of nitrous oxide emission and mitigation potential from maize and wheat fields at a global scale

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    This work was carried out by the International Maize and Wheat Improvement Center (CIMMYT) in collaboration with farmers and funded by the CGIAR research programs (CRPs) on Climate Change, Agriculture and Food Security (CCAFS). CCAFS' work is supported by CGIAR Fund Donors and through bilateral funding agreements. For details, please visit https://ccafs.cgiar.org/donors. The views expressed in this paper cannot be taken to reflect the official opinions of these organizations. The dataset associated with this manuscript will be available together with the supplementary materials of this manuscript.Peer reviewedPublisher PD

    Active pharmaceutical ingredients entering the aquatic environment from wastewater treatment works: A cause for concern?

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    publisher: Elsevier articletitle: Active pharmaceutical ingredients entering the aquatic environment from wastewater treatment works: A cause for concern? journaltitle: Science of The Total Environment articlelink: http://dx.doi.org/10.1016/j.scitotenv.2017.09.101 content_type: article copyright: © 2017 Elsevier B.V. All rights reserved

    Chapter 19 Noise pollution and its impact on human health and the environment

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    This chapter deals with (1) the basic theory of sound propagation; (2) an overview of noise pollution problem in view of policy and standards by the World Health Organization, the United States, and the European Union; (3) noise exposure sources from aircraft, road traffic and railways, in-vehicle, work, and construction sites, and occupations, and households; (4) the noise pollution impact on human health and the biological environment; (5) modeling of regional noise-affected habitats in protected and unprotected land areas and the marine environment; (6) noise control measures and sustainability in view of sustainable building design, noise mapping, and control measures such as barriers and berms along roadsides, acoustic building materials, roadway vehicle noise source control, road surface, and pavement materials; and (7) environmental noise pollution management measures and their impact on human health
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