Constrained Analysis of Topologically Massive Gravity

We quantize the Einstein gravity in the formalism of weak gravitational fields by using the constrained Hamiltonian method. Special emphasis is given to the 2+1 spacetime dimensional case where a (topological) Chern-Simons term is added to the Lagrangian.Comment: 15 pages, IF-UFRJ-21/9

2nd International Conference on Math Education and Technology 2024 (ICMET2024): book of abstracts

No abstract available.publishe

Singular Fermi Liquids

An introductory survey of the theoretical ideas and calculations and the experimental results which depart from Landau Fermi-liquids is presented. Common themes and possible routes to the singularities leading to the breakdown of Landau Fermi liquids are categorized following an elementary discussion of the theory. Soluble examples of Singular Fermi liquids (often called Non-Fermi liquids) include models of impurities in metals with special symmetries and one-dimensional interacting fermions. A review of these is followed by a discussion of Singular Fermi liquids in a wide variety of experimental situations and theoretical models. These include the effects of low-energy collective fluctuations, gauge fields due either to symmetries in the hamiltonian or possible dynamically generated symmetries, fluctuations around quantum critical points, the normal state of high temperature superconductors and the two-dimensional metallic state. For the last three systems, the principal experimental results are summarized and the outstanding theoretical issues highlighted.Comment: 170 pages; submitted to Physics Reports; a single pdf file with high quality figures is available from http://www.lorentz.leidenuniv.nl/~saarloo

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Projeto e dimensionamento de um sistema de freio aplicado a um protótipo de veículo para competição fora de estrada

This course work aims to present the brake system design of a baja SAE prototype, presenting all the stages of the project, as well as a justification of the selection of each of the components of the system. To reduce the expenses of the system were used cost optimization tools. The brakes can be activated in different ways, with the hydraulic drive being the most used. The disc brake was selected for the design. Along with floating type brake calipers, which has the advantage of compensating small bores on the disc. For the development of the low SAE prototype, the Modular Function Deployment (MFD) was applied, which allows the designer to choose the modular design from the reasons specified in the design. The Quality Function Deployment (QFD) was applied in the improvement and improvement of the product, the Engineering and Value Analysis (EAV) was applied, making it possible to determine the components that have a high cost in relation to the function they perform. Finally the Design for Manufacturing and Assembly (DFMA) was ideal to make a design of manufacture, assembly of components during the assembly and maintenance of the system. The parts selection was used as a parallel measurement with the design, to suit the needs of the project. The present study made it possible to apply the knowledge acquired during the period in which I was part of the Baja da Peste team, as well as everything that was seen in the classroom during the course of mechanical engineering, thus contributing to my training.Este trabalho de conclusão de curso tem por objetivo apresentar o dimensionamento do sistema de freio de um protótipo baja SAE, apresentando todas as etapas do projeto, bem como a justificativa da seleção de cada componente deste sistema. Para redução das despesas do sistema foram utilizadas ferramentas de otimização de custos. Os freios podem ser acionados de diversas formas, sendo o acionamento hidráulico o mais utilizado. O freio a disco foi o selecionado para o projeto. Juntamente com pinças do tipo flutuante, que tem como vantagem compensar pequenos empenos no disco. Para desenvolvimento do protótipo baja SAE foi aplicado o Desdobramento da Função Modular (MFD), que permite que o projetista escolha o design modular a partir das razões especificadas no projeto. O Desdobramento da Função Qualidade (QFD), foi aplicado no desenvolvimento e melhoria do produto, a Engenharia e Análise do Valor (EAV) foi aplicada, possibilitando determinar os componentes que tem custo elevado em relação a função que eles exercem. Por fim o Projeto para Manutenção e Montagem (DFMA) foi aplicado ao projeto a fim de facilitar a fabricação, minimizar os erros durante a montagem e manutenção do sistema. A seleção das peças a serem utilizadas foi feita de forma paralela com o dimensionamento, de modo que atendessem as necessidades do projeto. O presente estudo possibilitou aplicar os conhecimentos adquiridos no período em que fiz parte da equipe Baja da Peste, bem como tudo que foi visto em sala de aula durante o curso de engenharia mecânica, contribuindo assim para a minha formação

Awareness and knowledge of HPV, cervical cancer, and vaccines in young women after first delivery in São Paulo, Brazil : a cross-sectional study

BACKGROUND: The success of HPV vaccination programs will require awareness regarding HPV associated diseases and the benefits of HPV vaccination for the general population. The aim of this study was to assess the level of awareness and knowledge of human papillomavirus (HPV) infection, cervical cancer prevention, vaccines, and factors associated with HPV awareness among young women after birth of the first child. METHODS: This analysis is part of a cross-sectional study carried out at Hospital Maternidade Leonor Mendes de Barros, a large public maternity hospital in Sao Paulo. Primiparous women (15-24 years) who gave birth in that maternity hospital were included. A questionnaire that included questions concerning knowledge of HPV, cervical cancer, and vaccines was applied. To estimate the association of HPV awareness with selected factors, prevalence ratios (PR) were estimated using a generalized linear model (GLM). RESULTS: Three hundred and one primiparous women were included; 37% of them reported that they "had ever heard about HPV", but only 19% and 7%, respectively, knew that HPV is a sexually transmitted infection (STI) and that it can cause cervical cancer. Seventy-four percent of interviewees mentioned the preventive character of vaccines and all participants affirmed that they would accept HPV vaccination after delivery. In the multivariate analysis, only increasing age (P for trend = 0.021) and previous STI (P < 0.001) were factors independently associated with HPV awareness ("had ever heard about HPV"). CONCLUSIONS: This survey indicated that knowledge about the association between HPV and cervical cancer among primiparous young women is low. Therefore, these young low-income primiparous women could benefit greatly from educational interventions to encourage primary and secondary cervical cancer prevention programs.This study was supported by a research grant from Department of Immunization, Vaccines and Biologicals, World Health Organization (ref: V20-181-13). The authors are grateful to Dr M.T. Aguado for helpful discussions. We are also grateful to Dr Corintio Mariani Neto for the unconditional support provided during field work and to nurses from Hospital Maternidade Leonor Mendes de Barros

Stellar kinematics and metallicities in the ultra-faint dwarf galaxy Reticulum II

Based on data obtained from the ESO Science Archive Facility under request number 157689