7,373 research outputs found
In Deed: A Survey of Programs and Activities Related to Identity and Mission: Le Moyne College
Discovering Shakespeare’s Personal Style: Editing and Connoisseurship in the Eighteenth Century
This chapter examines the use of connoisseurial rhetoric by Shakespeare editors and critics over the course of the eighteenth century, beginning with Alexander Pope in 1723–5 and concluding with George Steevens in the 1780s and 1790s. Connoisseurship was originally developed by art critics as a discourse for authenticating paintings and drawings. Beginning with Pope, however, literary editors began to draw upon it as an analogy for representing authorial style. As I shall show through an examination of Steevens’s work in compiling the first chronological catalogue of William Hogarth’s prints and paintings, this convergence between art criticism and textual criticism involved more than a simple exchange of metaphors. Connoisseurship offered critics such as Steevens new ways of looking at artworks and assessing their genuineness, modes of vision that could be applied as readily to plays as to paintings. The eighteenth-century art market relied upon the expertise of the connoisseur, who could guarantee that a given painting stemmed from the hand of a particular master. Shakespeare publishing in the eighteenth century likewise came to depend on the expertise of the editor, who could reliably identify Shakespeare’s personal style and distinguish the genuine from the spurious
TREEOME: A framework for epigenetic and transcriptomic data integration to explore regulatory interactions controlling transcription
Motivation: Predictive modelling of gene expression is a powerful framework
for the in silico exploration of transcriptional regulatory interactions
through the integration of high-throughput -omics data. A major limitation of
previous approaches is their inability to handle conditional and synergistic
interactions that emerge when collectively analysing genes subject to different
regulatory mechanisms. This limitation reduces overall predictive power and
thus the reliability of downstream biological inference.
Results: We introduce an analytical modelling framework (TREEOME: tree of
models of expression) that integrates epigenetic and transcriptomic data by
separating genes into putative regulatory classes. Current predictive modelling
approaches have found both DNA methylation and histone modification epigenetic
data to provide little or no improvement in accuracy of prediction of
transcript abundance despite, for example, distinct anti-correlation between
mRNA levels and promoter-localised DNA methylation. To improve on this, in
TREEOME we evaluate four possible methods of formulating gene-level DNA
methylation metrics, which provide a foundation for identifying gene-level
methylation events and subsequent differential analysis, whereas most previous
techniques operate at the level of individual CpG dinucleotides. We demonstrate
TREEOME by integrating gene-level DNA methylation (bisulfite-seq) and histone
modification (ChIP-seq) data to accurately predict genome-wide mRNA transcript
abundance (RNA-seq) for H1-hESC and GM12878 cell lines.
Availability: TREEOME is implemented using open-source software and made
available as a pre-configured bootable reference environment. All scripts and
data presented in this study are available online at
http://sourceforge.net/projects/budden2015treeome/.Comment: 14 pages, 6 figure
In Deed: A Survey of Programs and Activities Related to Identity and Mission: Fordham University
Readers and Reading in the First World War
This essay consists of three individually authored and interlinked sections. In ‘A Digital Humanities Approach’, Francesca Benatti looks at datasets and databases (including the UK Reading Experience Database) and shows how a systematic, macro-analytical use of digital humanities tools and resources might yield answers to some key questions about reading in the First World War. In ‘Reading behind the Wire in the First World War’ Edmund G. C. King scrutinizes the reading practices and preferences of Allied prisoners of war in Mainz, showing that reading circumscribed by the contingencies of a prison camp created an unique literary community, whose legacy can be traced through their literary output after the war. In ‘Book-hunger in Salonika’, Shafquat Towheed examines the record of a single reader in a specific and fairly static frontline, and argues that in the case of the Salonika campaign, reading communities emerged in close proximity to existing centres of print culture. The focus of this essay moves from the general to the particular, from the scoping of large datasets, to the analyses of identified readers within a specific geographical and temporal space. The authors engage with the wider issues and problems of recovering, interpreting, visualizing, narrating, and representing readers in the First World War
Julian of Norwich and her children today: Editions, translations and versions of her revelations
The viability of such concepts as "authorial intention," "the original text," "critical edition" and, above all, "scholarly editorial objectivity" is not what it was, and a study of the textual progeny of the revelations of Julian of Norwich--editions, versions, translations and selections--does little to rehabilitate them. Rather it tends to support the view that a history of reading is indeed a history of misreading or, more positively, that texts can have an organic life of their own that allows them to reproduce and evolve quite independently of their author. Julian's texts have had a more robustly continuous life than those of any other Middle English mystic. Their history--in manuscript and print, in editions more or less approximating Middle English and in translations more or less approaching Modern English--is virtually unbroken since the fifteenth century. But on this perilous journey, many and strange are the clutches into which she and her textual progeny have fallen
Flared landing approach flying qualities. Volume 2: Appendices
An in-flight research study was conducted utilizing the USAF/Total In-Flight Simulator (TIFS) to investigate longitudinal flying qualities for the flared landing approach phase of flight. A consistent set of data were generated for: determining what kind of command response the pilot prefers/requires in order to flare and land an aircraft with precision, and refining a time history criterion that took into account all the necessary variables and the characteristics that would accurately predict flying qualities. Seven evaluation pilots participated representing NASA Langley, NASA Dryden, Calspan, Boeing, Lockheed, and DFVLR (Braunschweig, Germany). The results of the first part of the study provide guidelines to the flight control system designer, using MIL-F-8785-(C) as a guide, that yield the dynamic behavior pilots prefer in flared landings. The results of the second part provide the flying qualities engineer with a derived flying qualities predictive tool which appears to be highly accurate. This time-domain predictive flying qualities criterion was applied to the flight data as well as six previous flying qualities studies, and the results indicate that the criterion predicted the flying qualities level 81% of the time and the Cooper-Harper pilot rating, within + or - 1%, 60% of the time
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