Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy.

Spinal muscular atrophy (SMA) is an early-onset motor neuron disease that leads to loss of muscle function. Butyrate (BA)-based compounds markedly improve the survival and motor phenotype of SMA mice. In this study, we examine the protective effects of the BA prodrug pivaloyloxymethyl butyrate (AN9) on the survival of SMNΔ7 SMA mice. Oral administration of AN9 beginning at PND04 almost doubled the average lifespan of SMNΔ7 SMA mice. AN9 treatment also increased the growth rate of SMNΔ7 SMA mice when compared to vehicle-treated SMNΔ7 SMA mice. In conclusion, BA prodrugs like AN9 have ameliorative effects on SMNΔ7 SMA mice

Forest restoration for homeowners: A guide for residents of southwestern ponderosa pine forests

If you live among ponderosa pines, you can reduce fire risks to your home and property by carrying out restoration-based landscaping and fire-prevention projects around your house. Use these tips as guides toward restoring ecological health and living safely in the Southwests beautiful, but fire-prone, ponderosa pine forests

Crustal structure of the Murray Ridge, northwest Indian Ocean, from wide-angle seismic data

The Murray Ridge/Dalrymple Trough system forms the boundary between the Indian and Arabian plates in the northern Arabian Sea. Geodetic constraints from the surrounding continents suggest that this plate boundary is undergoing oblique extension at a rate of a few millimetres per year. We present wide-angle seismic data that constrains the composition of the Ridge and of adjacent lithosphere beneath the Indus Fan. We infer that Murray Ridge, like the adjacent Dalrymple Trough, is underlain by continental crust, while a thin crustal section beneath the Indus Fan represents thinned continental crust or exhumed serpentinized mantle that forms part of a magma-poor rifted margin. Changes in crustal structure across the Murray Ridge and Dalrymple Trough can explain short-wavelength gravity anomalies, but a long-wavelength anomaly must be attributed to deeper density contrasts that may result from a large age contrast across the plate boundary. The origin of this fragment of continental crust remains enigmatic, but the presence of basement fabrics to the south that are roughly parallel to Murray Ridge suggests that it separated from the India/Seychelles/Madagascar block by extension during early breakup of Gondwana

The Role of Friction in Compaction and Segregation of Granular Materials

We investigate the role of friction in compaction and segregation of granular materials by combining Edwards' thermodynamic hypothesis with a simple mechanical model and mean-field based geometrical calculations. Systems of single species with large friction coefficients are found to compact less. Binary mixtures of grains differing in frictional properties are found to segregate at high compactivities, in contrary to granular mixtures differing in size, which segregate at low compactivities. A phase diagram for segregation vs. friction coefficients of the two species is generated. Finally, the characteristics of segregation are related directly to the volume fraction without the explicit use of the yet unclear notion of compactivity.Comment: 9 pages, 6 figures, submitted to Phys. Rev.

Linear response of vibrated granular systems to sudden changes in the vibration intensity

The short-term memory effects recently observed in vibration-induced compaction of granular materials are studied. It is shown that they can be explained by means of quite plausible hypothesis about the mesoscopic description of the evolution of the system. The existence of a critical time separating regimes of ``anomalous'' and ``normal'' responses is predicted. A simple model fitting into the general framework is analyzed in the detail. The relationship between this work and previous studies is discussed.Comment: 10 pages, 6 figures; fixed errata, updtated reference

Feasibility study and design concept for an orbiting ice-penetrating radar sounder to characterize in three-dimensions the Europan ice mantle down to (and including) any ice/ocean interface

This report presents a radar sounding model based on the range of current working hypotheses for the nature of Europa's icy shell.Institute for Geophysic

Phase transitions in the steady state behavior of mechanically perturbed spin glasses and ferromagnets

We analyze the steady state regime of systems interpolating between spin glasses and ferromagnets under a tapping dynamics recently introduced by analogy with the dynamics of mechanically perturbed granular media. A crossover from a second order to first order ferromagnetic transition as a function of the spin coupling distribution is found. The flat measure over blocked states introduced by Edwards for granular media is used to explain this scenario. Annealed calculations of the Edwards entropy are shown to qualitatively explain the nature of the phase transitions. A Monte-Carlo construction of the Edwards measure confirms that this explanation is also quantitatively accurate

Slow relaxation in granular compaction

Experimental studies show that the density of a vibrated granular material evolves from a low density initial state into a higher density final steady state. The relaxation towards the final density value follows an inverse logarithmic law. We propose a simple stochastic adsorption-desorption process which captures the essential mechanism underlying this remarkably slow relaxation. As the system approaches its final state, a growing number of beads have to be rearranged to enable a local density increase. In one dimension, this number grows as $N=\rho/(1-\rho)$, and the density increase rate is drastically reduced by a factor $e^{-N}$. Consequently, a logarithmically slow approach to the final state is found $\rho_{\infty}-\rho(t)\cong 1/\ln t$.Comment: revtex, 4 pages, 3 figures, also available from http://arnold.uchicago.edu/~ebn

Analysis by x-ray microtomography of a granular packing undergoing compaction

Several acquisitions of X-ray microtomography have been performed on a beads packing while it compacts under vertical vibrations. An image analysis allows to study the evolution of the packing structure during its progressive densification. In particular, the volume distribution of the pores reveals a large tail, compatible to an exponential law, which slowly reduces as the system gets more compact. This is quite consistent, for large pores, with the free volume theory. These results are also in very good agreement with those obtained by a previous numerical model of granular compaction.Comment: 4 pages, 4 figures. Latex (revtex4). to be published in Phys. Rev.

Compaction of Rods: Relaxation and Ordering in Vibrated, Anisotropic Granular Material

We report on experiments to measure the temporal and spatial evolution of packing arrangements of anisotropic, cylindrical granular material, using high-resolution capacitive monitoring. In these experiments, the particle configurations start from an initially disordered, low-packing-fraction state and under vertical vibrations evolve to a dense, highly ordered, nematic state in which the long particle axes align with the vertical tube walls. We find that the orientational ordering process is reflected in a characteristic, steep rise in the local packing fraction. At any given height inside the packing, the ordering is initiated at the container walls and proceeds inward. We explore the evolution of the local as well as the height-averaged packing fraction as a function of vibration parameters and compare our results to relaxation experiments conducted on spherically shaped granular materials.Comment: 9 pages incl. 7 figure