On the efficiency of electrokinetic pumping of liquids through nanoscale channels

Electrokinetic pumps are a novel microfluidic technology being pursued for microscale high performance liquid chromatography (HPLC) and heat transfer applications. These pumps are typically reported to have efficiencies of only a few percent or less. We present an analytical and numerical investigation of the thermodynamic efficiency of electrokinetic pumping, solving the hydrodynamic and fully nonlinear Poisson-Boltzmann equations over a wide range of various dimensionless parameters. The numerical results show that efficiency as high as 15% may be attainable, when using uniform submicron-depth microchannels in substrates with moderately high zeta potentials, as well as using electrolytes with low specific conductivity (we identify practical candidate electrolytes). Simple design rules are given for pump dimensions and working electrolyte, based on dimensionless parameters such as the ratio of Debye layer thickness to channel depth, normalized zeta potential, and operating pressure. We compare our results with existing experimental data and provide practical design examples. (C) 2003 Elsevier B.V. All rights reserved.JYM was supported in her exchange visit to the University of Michigan by grant BK21 (Korea Advanced Institute of Science and Technology). Support for EFH was provided by the NSF Wireless Integrated Micro Systems (WIMS) Engineering Research Center at the University of Michigan. The authors would like to thank Stewart Griffiths and Phil Paul for many helpful comments

Biomolecular motors as novel prime movers for microTAS: Microfabrication and material issue

Biomolecular motors that have high efficiency and can generate substantial forces per motor but are truly nanoscopic are promising movers for microTAS. We demonstrate the feasibility of achieving unidirectional motion of microtubules though a microfluidic channel and concentrating microtubules and also describe an incompatibility between a commonly-used material (PDMS) and the motility of labeled microtubules