Gray Divorce and Social and Emotional Loneliness

Research consistently shows an association between marriage and divorce and long-term health, including mental health outcomes linked to loneliness and depression. And, recent evidence suggests that divorce at midlife and older, or so-called “gray divorce” has increased while divorce at younger ages has decreased. Using data from the Netherlands Kinship Panel Study (NKPS), this chapter explores the association between marital status and social and emotional loneliness, empha- sizing gray divorce. Contrary to expectations, compared to those continuously mar- ried (e.g., never divorced), gray divorce is not associated significantly with social loneliness, but divorce prior to midlife is. On the other hand, those who divorced prior to and after midlife were emotionally lonelier than those continuously mar- ried, regardless of birth cohort and remarriage. In addition, compared to their mar- ried counterparts of the same age, there was no association between divorce and social loneliness for women, but there was for men who divorced both before and after midlife. Among only the divorced group, gray divorce (versus younger divorce) was not associated significantly with social nor emotional loneliness for women or men. Also among only those who divorced, gray divorced men (versus younger divorced men) were less emotionally lonely, but this finding was not statistically significant. </p

Divorce and the Multidimensionality of Men and Women’s Mental Health: The Role of Social-Relational and Socio-Economic Conditions

Research consistently reveals that the divorced generally face more mental health problems than the married. Less attention however has been paid to positive mental health indicators. Insight in these however may help policy makers and care providers to see both the broader picture and stimulate active coping. Using data from the European Social Survey (2006–2007), differences in both feelings of depression, and in feelings of self-esteem, autonomy, and competence between the married (N = 14,072) and divorced (N = 4,304) are estimated for women and men separately. Drawing on stress and coping theories, we map how specific social-relational and socio-economic conditions relate. Analyses reveal that divorce is related not only to more feelings of depression, but also to lower levels of self-esteem and competence. Difference scores in mental health based on marital status are also found to differ significantly between men and women for competence, with the difference being more pronounced in men. Additionally, social-relational and socio-economic conditions explain much of the gap in depression scores – and to a lesser extent, in self-esteem and competence scores – between the married and divorced. Finally, some interesting gender differences were found in how social-relational and socio-economic conditions relate to mental health when divorced, with women especially seeming to benefit from advantageous socio-economic conditions

Immunopathogenesis of lymphatic filarial disease

Although two-thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ~ 40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, tropical pulmonary eosinophilia, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce changes that result in dilatation of lymphatics and thickening of the lymphatic vessel walls. Progressive lymphatic damage and pathology results from the summation of the effect of tissue alterations induced by both living and nonliving adult parasites, the host inflammatory response to the parasites and their secreted antigens, the host inflammatory response to the endosymbiont Wolbachia, and those seen as a consequence of secondary bacterial or fungal infections. Inflammatory damage induced by filarial parasites appears to be multifactorial, with endogenous parasite products, Wolbachia, and host immunity all playing important roles. This review will initially examine the prototypical immune responses engendered by the parasite and delineate the regulatory mechanisms elicited to prevent immune-mediated pathology. This will be followed by a discussion of the proposed mechanisms underlying pathogenesis, with the central theme being that pathogenesis is a two-step process - the first initiated by the parasite and host innate immune system and the second propagated mainly by the host’s adaptive immune system and by other factors (including secondary infections)