Miocardita eveniment cardiovascular major secundar infecției cu COVID-19-recenzia și analiza datelor din literatură | [COVID 19 myocarditis a major cardiovascular effect-review of clinical data]

SARS-CoV-2 infection represents a major global health problem. The clinical feature is polymorphic, the cardiovascular damage being frequently considered responsible for the death. Myocardial damage, even if it is suspected on clinical and laboratory criteria, is not clearly confirmed by imaging or morphological means, the pathophysiology of myocardial damage has not yet been elucidated. All this has a direct consequence, a partially ineffective therapeutic approach. Rezumat Infecția cu SARS-CoV-2 reprezintă o problemă majoră de sănătate globală. Tabloul clinic este polimorf, afectarea cardiovasculară fiind frecvent considerată responsabilă de deces. Afectarea miocardică, chiar dacă este bănuită pe criterii clinice și de laborator, nu este confirmată clar prin mijloace imagistice sau anatomopatologice, iar fiziopatologia afectării miocardice nu este încă elucidată. Toate acestea au drept consecință directă abordarea terapeutică parțial ineficientă.</jats:p

Sindromul Heyde. Stenoza aortică, factor de risc pentru sângerarea gastrointestinală | [Heyde syndrome. Aortic stenosis, risk factor for gastrointestinal bleeding]

Heyde syndrome is a multisystemic condition characterized by the presence of aortic stenosis, gastrointestinal bleeding, and acquired von Willebrand syndrome. We will present the case of an 81-year-old patient, known with symptomatic severe aortic stenosis, with permanent atrial fibrillation, recurrent pleurisy, and iron deficiency anemic syndrome secondary to upper digestive bleeding corrected with blood transfusions. Evaluation by endoscopy revealed gastric angiodysplasia, so after the complete paraclinical evaluation the diagnosis of Heyde syndrome was established. Valve surgery is the gold standard in the treatment of aortic stenosis associated with Heyde syndrome, the angiodysplasia being reversible after the intervention, and the deficiency of von Willebrand factor multimers is quickly recovered with the decrease of the risk of bleeding. Rezumat Sindromul Heyde este o afecțiune multisistemică caracterizată prin prezența stenozei aortice, sângerărilor gastrointestinale și a sindromului von Willebrand dobândit. Vom prezenta cazul unui pacient în vârstă de 81 ani, cunoscut cu stenoză aortică severă simptomatică, cu fibrilație atrială permanentă, pleurezie recidivantă și sindrom anemic feripriv secundar hemoragiei digestive superioare, corectat inclusiv cu preparate de sânge. Evaluarea prin endoscopie a relevat angiodisplazia gastrică, astfel după evaluarea paraclinică completă s-a stabilit diagnosticul de sindrom Heyde. Chirurgia valvulară este standardul de aur în tratamentul stenozei aortice asociată cu sindrom Heyde, angiodisplazia fiind reversibilă, iar deficitul de multimeri de factor von Willebrand este rapid recuperat cu scăderea riscului de sângerare.</jats:p

Entropy Analysis for Cilia-Generated Motion of Cu-Blood Flow of Nanofluid in an Annulus

In this study, a novel model of entropy generation effects measured in the Cu-blood flow of a nanofluid under the effect of ciliary-oriented motion is proposed. The effects of viscous dissipation are also taken into account. The physical model was composed with the incorporation of a low Reynolds number and long-wavelength phenomena. The exact solutions for the axial velocity, temperature and pressure gradient distribution were achieved successfully. Key findings are presented through a strategy of plotting the significant factors affecting the physical quantities of the stream. It was found that the heat absorption parameter and Brownian motion accounted for the large thermal transfer rate, while the effect of entropy was minimal compared to these factors in the center of the flow but increased on the walls in the case of Cu-blood flow. It can also be added that a more intense flow gave rise to the entropy effects. This study may be helpful in medical science as cilia play vital roles, which include cell migration and external fluid transport, in human tissues and some key organs. Moreover, the considered annulus-shaped geometry gives vital readings that are used in medical equipment such as endoscopes

Entropy Analysis for Cilia-Generated Motion of Cu-Blood Flow of Nanofluid in an Annulus

In this study, a novel model of entropy generation effects measured in the Cu-blood flow of a nanofluid under the effect of ciliary-oriented motion is proposed. The effects of viscous dissipation are also taken into account. The physical model was composed with the incorporation of a low Reynolds number and long-wavelength phenomena. The exact solutions for the axial velocity, temperature and pressure gradient distribution were achieved successfully. Key findings are presented through a strategy of plotting the significant factors affecting the physical quantities of the stream. It was found that the heat absorption parameter and Brownian motion accounted for the large thermal transfer rate, while the effect of entropy was minimal compared to these factors in the center of the flow but increased on the walls in the case of Cu-blood flow. It can also be added that a more intense flow gave rise to the entropy effects. This study may be helpful in medical science as cilia play vital roles, which include cell migration and external fluid transport, in human tissues and some key organs. Moreover, the considered annulus-shaped geometry gives vital readings that are used in medical equipment such as endoscopes.</jats:p