Hazards of sea level rise and dams built on the River Nile on water budget and salinity of the Nile Delta aquifer

Data availability: No data was used for the research described in the article.Code availability: Upon request.Supplementary material is available online at: https://www.sciencedirect.com/science/article/pii/S2214581823002872#sec0135 .Copyright © 2023 The Authors. Study region: The Nile Delta region consists of flat, low-lying areas, where most areas are used for agriculture. It covers an area of 22,000 km2, which is 2.20% of the total area of Egypt. Study focus: This study evaluates the water budget and the salinity due to the Sea Level Rise (SLR) and the reduction in the river water flow caused by the Grand Ethiopian Renaissance Dam (GERD) using the numerical code SEAWAT. Three filling scenarios were considered for the GERD reservoir at elevations 600 m, 621 m, and 645 m above mean sea level (AMSL) for the storage volumes of 17 billion cubic meters (BCM) (scenarios #1), 37.30 BCM (scenarios #2), and 74 BCM (scenarios #3). The impact of these fillings scenarios was combined with SLR of 25 cm, and increasing the abstraction rates from the Nile Delta aquifer by 25%, 50%, and 100%, respectively. New hydrological insights for the region: The study findings indicated that the SLR and the GERD reservoir filling with increasing pumping rates, especially during the filling periods, would influence the groundwater resources in the Nile Delta. The GERD reservoir filling could alter the freshwater, in which the aquifer salinity increased by 4.47%, 11.48%, and 29.99% for the three scenarios, respectively. The methodology and findings presented in this study might be useful for investing and comparing the impact of SLR and upstream dam projects on the downstream water budget and salinity at other coastal regions.Alban Kuriqi is grateful for the Foundation for Science and Technology's support through funding UIDB/04625/2020 from the research unit CERIS

Current and prospective pharmacological targets in relation to antimigraine action

Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon

Optimizing Irrigation Systems for Water Efficiency and Groundwater Sustainability in the Coastal Nile Delta

Data Availability: No data was used for the research described in the article.This study investigates the replacement of traditional surface irrigation methods with modern irrigation systems (MIS) including horizontal sprinkler, central pivot, surface drip, and subsurface drip aimed at improving water efficiency in the Nile Delta, Egypt. The primary objectives were to determine the optimal agricultural area for implementing MIS and to assess the effects of these systems on groundwater quantity and quality in the region. To achieve this, the LINDO software was employed to optimize land allocation for each irrigation method. At the same time, the SEAWAT code was utilized to simulate saltwater intrusion (SWI) in the Nile Delta aquifer. The transition from traditional surface irrigation to MIS resulted in significant water savings, reaching 2.15 × 10^9 m³. However, groundwater modeling indicated a decrease in groundwater levels, leading to an 8 % increase in aquifer salinity due to reduced infiltration of recharge water. These findings underscore the urgent need to revise outdated irrigation practices and enhance water management strategies in the Nile Delta to mitigate salinity issues in coastal aquifers. This research's outcomes are crucial for decision-makers and stakeholders in selecting appropriate irrigation methods, particularly in arid and semi-arid regions, to ensure sustainable water use and agricultural productivity.This study did not receive any funding

Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle

BACKGROUND: The steroid hormone environment in healthy horses seems to have a significant impact on the efficiency of their uterine immune response. The objective of this study was to characterize the changes in gene expression in the equine endometrium in response to the introduction of bacterial pathogens and the influence of steroid hormone concentrations on this expression. METHODS: Endometrial biopsies were collected from five horses before and 3 h after the inoculation of Escherichia coli once in oestrus (follicle >35 mm in diameter) and once in dioestrus (5 days after ovulation) and analysed using high-throughput RNA sequencing techniques (RNA-Seq). RESULTS: Comparison between time points revealed that 2422 genes were expressed at significantly higher levels and 2191 genes at significantly lower levels 3 h post inoculation in oestrus in comparison to pre-inoculation levels. In dioestrus, the expression of 1476 genes was up-regulated and 383 genes were down-regulated post inoculation. Many immune related genes were found to be up-regulated after the introduction of E. coli. These include pathogen recognition receptors, particularly toll-like receptors TLR2 and 4 and NOD-like receptor NLRC5. In addition, several interleukins including IL1B, IL6, IL8 and IL1ra were significantly up-regulated. Genes for chemokines, including CCL 2, CXCL 6, 9, 10, 11 and 16 and those for antimicrobial peptides, including secretory phospholipase sPLA(2), lipocalin 2, lysozyme and equine β-defensin 1, as well as the gene for tissue inhibitor for metalloproteinases TIMP-1 were also up-regulated post inoculation. CONCLUSION: The results of this study emphasize the complexity of an effective uterine immune response during acute endometritis and the tight balance between pro- and anti-inflammatory factors required for efficient elimination of bacteria. It is one of the first high-throughput analyses of the uterine inflammatory response in any species and several new potential targets for treatment of inflammatory diseases of the equine uterus have been identified. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-2139-3) contains supplementary material, which is available to authorized users

Light regulation of metabolic pathways in fungi

Light represents a major carrier of information in nature. The molecular machineries translating its electromagnetic energy (photons) into the chemical language of cells transmit vital signals for adjustment of virtually every living organism to its habitat. Fungi react to illumination in various ways, and we found that they initiate considerable adaptations in their metabolic pathways upon growth in light or after perception of a light pulse. Alterations in response to light have predominantly been observed in carotenoid metabolism, polysaccharide and carbohydrate metabolism, fatty acid metabolism, nucleotide and nucleoside metabolism, and in regulation of production of secondary metabolites. Transcription of genes is initiated within minutes, abundance and activity of metabolic enzymes are adjusted, and subsequently, levels of metabolites are altered to cope with the harmful effects of light or to prepare for reproduction, which is dependent on light in many cases. This review aims to give an overview on metabolic pathways impacted by light and to illustrate the physiological significance of light for fungi. We provide a basis for assessment whether a given metabolic pathway might be subject to regulation by light and how these properties can be exploited for improvement of biotechnological processes

An internet of things and blockchain based smart campus architecture

Rapid development in science and information technologies, such as the Internet of things, has led to a growth in the number of studies and research papers on smart cities in recent years and more specifically on the construction of smart campus technologies. This paper will review the concept of a smart campus, discuss the main technologies deployed, and then propose a new novel framework for a smart campus. The architecture of this new smart campus approach will be discussed with particular consideration of security and privacy systems, the Internet of things, and blockchain technologies