Les mots de la mer : le parler des pêcheurs de Nazaré

L’identité culturelle d’une communauté se révèle de différentes manières. Si chez les pêcheurs l’osmose entre l’élément marin et les hommes se reflète dans leurs pratiques quotidiennes, leurs rites tant profanes que religieux, cette identité s’exprime également dans le verbe. Cet article a pour objet de montrer que le langage, qui reproduit la pensée, n'existe que par l'objet auquel il renvoie, la pêche et le monde marin des pêcheurs de Nazaré. Différentes expressions de cette pensée illustrent le propos afin de démontrer aussi que l’emprunt de vocables spécifiques au métier est à l’origine d’un portugais identitaire et patrimonial permettant de distinguer les Nazaréens des autres communautés tant maritimes que terrestres.info:eu-repo/semantics/publishedVersio

Les mots de la mer : le parler des pêcheurs de Nazaré

L’identité culturelle d’une communauté se révèle de différentes manières. Si chez les pêcheurs l’osmose entre l’élément marin et les hommes se reflète dans leurs pratiques quotidiennes, leurs rites tant profanes que religieux, cette identité s’exprime également dans le verbe. Cet article a pour objet de montrer que le langage, qui reproduit la pensée, n'existe que par l'objet auquel il renvoie, la pêche et le monde marin des pêcheurs de Nazaré. Différentes expressions de cette pensée illustrent le propos afin de démontrer aussi que l’emprunt de vocables spécifiques au métier est à l’origine d’un portugais identitaire et patrimonial permettant de distinguer les Nazaréens des autres communautés tant maritimes que terrestres.info:eu-repo/semantics/publishedVersio

Superconducting Magnets for a Final Focus Upgrade of ATF2

Original publication available at http://www.jacow.org/International audienceThe Accelerator Test Facility 2 (ATF2) at KEK is a scaled version of the final focus (FF) design proposed for a future linear collider (LC). A primary ATF2 goal is to experimentally verify the FF technology needed to obtain very small, stable beam spots at an LC interaction point [1]. Initially the ATF2 FF is made using conventional (warm) quadrupole and sextupole magnets. We intend to upgrade the ATF2 FF by replacing conventional magnets with new superconducting ones that use the same technology proposed for the International Linear Collider (ILC) baseline FF magnets [2]. With this upgrade we can investigate smaller interaction point beta-functions and study superconducting magnet vibration stability in an accelerator environment. Our ATF2 magnet cryostat design incorporates features to facilitate monitoring of the cold mass movement via interferometric techniques. The status and future plans for the ATF2 superconducting magnet upgrade are reported here

LARP Long Nb3Sn Racetrack Coil Program

Development of high-performance Nb{sub 3}Sn quadrupoles is one of the major goals of the LHC Accelerator Research Program (LARP). As part of this program, long racetrack magnets are being made in order to check that the change in coil length that takes place during reaction is correctly accounted for in the quadrupole design and to check for length effects in implementing the 'shell' method of coil support. To check the racetrack magnet manufacturing plan, a short racetrack magnet is being made. This magnet will be the first to use restack-rod process Nb{sub 3}Sn, making it a 'long sample' test vehicle for this new material. The paper reports the reaction and characterization of the Nb{sub 3}Sn, and construction features and test results from the short racetrack magnet. The paper also reports on the status of the construction of the first long racetrack magnet

Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: A pragmatic, randomised clinical trial

Introduction: Postoperative delirium, arbitrarily defined as occurring within 5 days of surgery, affects up to 50% of patients older than 60 after a major operation. This geriatric syndrome is associated with longer intensive care unit and hospital stay, readmission, persistent cognitive deterioration and mortality. No effective preventive methods have been identified, but preliminary evidence suggests that EEG monitoring during general anaesthesia, by facilitating reduced anaesthetic exposure and EEG suppression, might decrease incident postoperative delirium. This study hypothesises that EEG-guidance of anaesthetic administration prevents postoperative delirium and downstream sequelae, including falls and decreased quality of life. Methods and analysis This is a 1232 patient, block-randomised, double-blinded, comparative effectiveness trial. Patients older than 60, undergoing volatile agent-based general anaesthesia for major surgery, are eligible. Patients are randomised to 1 of 2 anaesthetic approaches. One group receives general anaesthesia with clinicians blinded to EEG monitoring. The other group receives EEG-guidance of anaesthetic agent administration. The outcomes of postoperative delirium (≤5 days), falls at 1 and 12 months and health-related quality of life at 1 and 12 months will be compared between groups. Postoperative delirium is assessed with the confusion assessment method, falls with ProFaNE consensus questions and quality of life with the Veteran's RAND 12-item Health Survey. The intention-to-treat principle will be followed for all analyses. Differences between groups will be presented with 95% CIs and will be considered statistically significant at a two-sided p<0.05. Ethics and dissemination Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) is approved by the ethics board at Washington University. Recruitment began in January 2015. Dissemination plans include presentations at scientific conferences, scientific publications, internet-based educational materials and mass media. Trial registration number NCT02241655; Pre-results

Zymosan-triggered association of tyrosine phosphoproteins and lyn kinase with cytoskeleton in human monocytes.

Abstract Phagocytosis of pathogens and inert particles such as zymosan by macrophages, and related secretory functions require the combination of several intracellular signals and the reorganization of cytoskeleton. We recently reported that zymosan stimulated the tyrosine phosphorylations of several endogenous substrates in human monocytes. In this work, the relationship between zymosan-stimulated tyrosine phosphoproteins and detergent-insoluble material considered as cytoskeleton was investigated. Triton X-100-insoluble fraction contained two proteins of 53 and 56 kDa that were tyrosine phosphorylated after only 5 min of stimulation with zymosan and remained labeled for 30 min. Because 53- and 56-kDa phosphoproteins migrated, as did some components of the src tyrosine kinase family, namely p53-56lyn, we wondered if 53- and 56-kDa phosphoproteins were related to lyn kinase. First, the amount of immunoreactive p53-56lyn increased in Triton X-100-insoluble fraction as did zymosan-stimulated tyrosine phosphoproteins. This property of p53-56lyn was unique, as no other member of the src family was found in this fraction. Second, when the immunoblots were reprobed with anti-phosphotyrosine mAb, the m.w. of p53-56lyn and tyrosine-phosphorylated proteins were identical in apparent size. Third, p53-56lyn was probably activated after cell stimulation with zymosan, because the phosphorylation levels of a synthetic copolymer of glutamine-tyrosine were increased in Triton X-100-insoluble fraction. In addition, we studied the distribution of lyn kinase and tyrosine phosphoproteins in phagocytozing monocytes. By using immunofluorescence, we showed that lyn kinase was located preferentially in the periphagosomal region in a specific manner, as an src tyrosine kinase such as p59hck, which was not associated with cytoskeleton, was not concentrated around the vacuoles. Moreover, periphagosomal phosphoproteins were also detected and found to be colocalized with polymerized actin. Because zymosan interacts with human monocytes via beta 2 integrins, which are known to be cytoskeleton-associated, we suggest that p53-56lyn provides the molecular link between zymosan receptors and cytoskeleton, and directs the cytoskeletal reorganization in the periphagosomal area.</jats:p