4,793 research outputs found
Pengembangan Kapasitas Tenaga Pendidik Dan Peran Lembaga Pendidikan
Pendidikan merupakan investasi jangka panjang yang akan selalu menarik untuk terus menerus diperbincangkan. Diperlukan kehati-hatian dalam menentukan kebijakan pendidikan karena pendidikan merupakan penentu dari kemajuan suatu masyarakat bahkan negara. Tulisan sederhana ini memaparkan tentang pengembangan kapasitas tenaga pendidik sebagai ujung tombak pendidikan, pemahaman terhadap peserta didik dan juga tentang lembaga pendidikan yang merupakan tempat potensial untuk mengembangkan dan meningkatkan kualitas sumber daya manusia. Pembahasannya didasarkan atas kajian teoritik dari berbagai sumber dan kajian empiris dari para peneliti terdahulu
Automated discrimination of psychotropic drugs in mice via computer vision-based analysis
Cataloged from PDF version of article.We developed an inexpensive computer vision-based method utilizing an algorithm which differentiates
drug-induced behavioral alterations. The mice were observed in an open-field arena and their activity
was recorded for 100 min. For each animal the first 50 min of observation were regarded as the drug-free
period. Each animal was exposed to only one drug and they were injected (i.p.) with either amphetamine
or cocaine as the stimulant drugs or morphine or diazepam as the inhibitory agents. The software divided
the arena into virtual grids and calculated the number of visits (sojourn counts) to the grids and instantaneous
speeds within these grids by analyzing video data. These spatial distributions of sojourn counts and
instantaneous speeds were used to construct feature vectors which were fed to the classifier algorithms
for the final step of matching the animals and the drugs. The software decided which of the animals were
drug-treated at a rate of 96%. The algorithm achieved 92% accuracy in sorting the data according to the
increased or decreased activity and then determined which drug was delivered. The method differentiated
the type of psychostimulant or inhibitory drugs with a success ratio of 70% and 80%, respectively.
This method provides a new way to automatically evaluate and classify drug-induced behaviors in mice.
Crown Copyright © 2009 Published by Elsevier B.V. All rights reserved
Nanotransfer Printing of Organic and Carbon Nanotube Thin-Film Transistors on Plastic Substrates
A printing process for high-resolution transfer of all components for organic
electronic devices on plastic substrates has been developed and demonstrated
for pentacene (Pn), poly (3-hexylthiophene) and carbon nanotube (CNT) thin-film
transistors (TFTs). The nanotransfer printing process allows fabrication of an
entire device without exposing any component to incompatible processes and with
reduced need for special chemical preparation of transfer or device substrates.
Devices on plastic substrates include a Pn TFT with a saturation, field-effect
mobility of 0.09 cm^2 (Vs)^-1 and on/off ratio approximately 10^4 and a CNT TFT
which exhibits ambipolar behavior and no hysteresis.Comment: to appear in Applied Physics Letter
Health, Financial Incentives and Retirement in Spain
We estimate the impact of health and financial incentives on the retirement transitions of older workers in Spain. Individual measures of pension wealth, peak and accrual values are constructed using labor market histories and health shocks are derived as changes in a composite health stock measure over time. We examine labour market exits into both old age retirement and a broader definition of retirement including inactivity, while controlling for unobserved heterogeneity. We find that pension wealth, accrual and peak value are significant determinants of retirement decisions, although their effect is weaker in the case of the broad definition of retirement. Initial health stock shows a significant impact on both definitions of retirement. Only large negative health shocks have a significant effect on the probability of entering the broader definition of retirement. Unlike previous literature, we find that (i) financial incentives, when measured adequately, exert a greater impact on retirement behaviour than health shocks, and (ii) initial health stock plays a more important role than health shocks in determining retirement decisions. We also perform simulations of a recently enacted reform of pension incentives and show how its expected effects compare to those of health improvements
Determining the origin of synchronous multifocal bladder cancer by exome sequencing
Background: Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses. A potential cause of this uncertainty may be the small number of genetic mutations previously used to quantify the relationship between these tumours. Methods: To better understand the genetic lineage of these tumours we conducted exome sequencing of synchronous multifocal pTa urothelial bladder cancers at a high depth, using multiple samples from three patients. Results: Phylogenetic analysis of high confidence single nucleotide variants (SNV) demonstrated that the sequenced multifocal bladder cancers arose from a clonal origin in all three patients (bootstrap value 100 %). Interestingly, in two patients the most common type of tumour-associated SNVs were cytosine mutations of TpC*dinucleotides (Fisher's exact test p < 10-41), likely caused by APOBEC-mediated deamination. Incorporating these results into our clonal model, we found that TpC*type mutations occurred 2-5× more often among SNVs on the ancestral branches than in the more recent private branches (p < 10-4) suggesting that TpC*mutations largely occurred early in the development of the tumour. Conclusions: These results demonstrate that synchronous multifocal bladder cancers frequently arise from a clonal origin. Our data also suggests that APOBEC-mediated mutations occur early in the development of the tumour and may be a driver of tumourigenesis in non-muscle invasive urothelial bladder cancer. © 2015 Acar et al
Who can predict their own Demise? Accuracy of Longevity Expectations by Education and Cognition
__Abstract__
Biased longevity expectations will lead to suboptimal decisions regarding saving, retirement, annuitization and health, with consequences for wellbeing in old age. Systematic differences in the accuracy of longevity expectations may partly explain heterogeneity in economic behaviour by education and cognitive functioning. Analysis of eight waves of the US Health and Retirement Study reveals that individuals with lower levels of education and cognitive functioning report survival probabilities that are less accurate in predicting their in-sample mortality. There is little evidence that the gradients in the veracity of expectations are due to the less educated and cognitively able responding less to changes in objective mortality risks. However, high school dropouts and the least cognitively able report survival probabilities that are less stable and display greater un explained variability. These disadvantaged groups appear to be less confident in their longevity beliefs, which is justified given that their expectations are less accurate
Observation of and Evidence for
We report the first observation of and first
evidence for , which are CP eigenstate decay modes.
These results are obtained from of data collected at
the resonance with the Belle detector at the KEKB
collider. We measure the branching fractions with a significance of , and
with a significance of . The last error
listed is due to uncertainty in the number of produced pairs.Comment: 5 pages, 2 figures, 2 tables, published in PR
Measurement of and branching ratios
We report an improved measurement of and branching ratios using 605 fb of data collected with the Belle
detector at the KEKB asymmetric-energy collider. The measured
branching ratios with respect to the Cabibbo-favored modes are = 0.18990.0022
and =
0.08030.0019 where the first uncertainties are statistical and
the second are systematic
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Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016.
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
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