9,875 research outputs found
Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets
Genomic and molecular landscape of DNA damage repair deficiency across The Cancer Genome Atlas
Characterisation of microstructure, defect and high-cycle-fatigue behaviour in a stainless steel joint processed by brazing
We report the characterisation of microstructures and high-cycle-fatigue (HCF) properties of Type 304 stainless steel joints processed by brazing. Pure copper was applied as the filler metal for brazing at 1120 °C. A two-phase microstructure was obtained within the joint region: the star-shaped precipitates and copper matrix. The precipitates with an average size of 0.43 μm were rich in iron and chromium. A fixed orientation relationship was found between the precipitates and copper matrix. The joint exhibited much higher tensile strength and HCF life when compared to pure copper. The strength enhancement can be attributed to the presence of precipitates. Furthermore, the effect of joint interface roughness as well as defects was critically investigated. The joint interface roughness showed little influence on the HCF lives. Post-examinations revealed that fatigue crack initiation and propagation occurred entirely within the joint region, hence being consistent with the similar HCF lives regardless of the pre-defined interface roughness conditions. In addition, it was found that the HCF lives decreased exponentially with the increase of initial defect area. Fractography analysis revealed that fatigue striation spacings near the crack initiation zone increased with the increase of defect area, suggesting that the larger defects result in higher crack growth rate, hence shorten the overall fatigue life.</div
Cognitive Radio Networks: Realistic or Not?
A large volume of research has been conducted in the cognitive radio (CR)
area the last decade. However, the deployment of a commercial CR network is yet
to emerge. A large portion of the existing literature does not build on real
world scenarios, hence, neglecting various important interactions of the
research with commercial telecommunication networks. For instance, a lot of
attention has been paid to spectrum sensing as the front line functionality
that needs to be completed in an efficient and accurate manner to enable an
opportunistic CR network architecture. This is necessary to detect the
existence of spectrum holes without which no other procedure can be fulfilled.
However, simply sensing (cooperatively or not) the energy received from a
primary transmitter cannot enable correct dynamic spectrum access. For example,
the low strength of a primary transmitter's signal does not assure that there
will be no interference to a nearby primary receiver. In addition, the presence
of a primary transmitter's signal does not mean that CR network users cannot
access the spectrum since there might not be any primary receiver in the
vicinity. Despite the existing elegant and clever solutions to the DSA problem
no robust, implementable scheme has emerged. In this paper, we challenge the
basic premises of the proposed schemes. We further argue that addressing the
technical challenges we face in deploying robust CR networks can only be
achieved if we radically change the way we design their basic functionalities.
In support of our argument, we present a set of real-world scenarios, inspired
by realistic settings in commercial telecommunications networks, focusing on
spectrum sensing as a basic and critical functionality in the deployment of
CRs. We use these scenarios to show why existing DSA paradigms are not amenable
to realistic deployment in complex wireless environments.Comment: Work in progres
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
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