The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTO-FFR) Study.

AIMS: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during submaximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). METHODS AND RESULTS: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93±0.05 vs. 0.87±0.08 vs. 0.84±0.08, p<0.001). A strong correlation and a close agreement at Bland-Altman analysis between cFFR and FFR were observed (r=0.90, p<0.001 and 95% CI of disagreement: from -0.042 to 0.11). ROC curve analysis showed an excellent accuracy (89%) of the cFFR cut-off of ≤0.85 in predicting an FFR value ≤0.80 (AUC 0.95 [95% CI: 0.94-0.96]), significantly better than that observed using resting Pd/Pa (AUC: 0.90, 95% CI: 0.88-0.91; p<0.001). A cFFR/FFR hybrid approach showed a significantly lower number of lesions requiring adenosine than a resting Pd/Pa/FFR hybrid approach (22% vs. 44%, p<0.0001). CONCLUSIONS: cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow limiting the use of adenosine to obtain FFR to a minority of stenoses with considerable savings of time and costs.info:eu-repo/semantics/publishedVersio

EROS variable stars: discovery of a slow nova in the SMC

We report the discovery of a slow nova found in the core of the Small Magellanic Cloud by the EROS microlensing survey. Nova SMC 1994 is a classical nova with a DQ Her type lightcurve characterized by a deep minimum. Low amplitude variations occuring on time-scales of hours and days are also detected at maximum light. Spectra collected during the nebular phase indicate that Nova SMC 1994 is similar to Galactic novae of the same class. Large helium enhancement in the shell is found and O and N enrichments are suspected. Based on observations collected at the European Southern Observatory, Chile

Rapidity Dependence of Charged Antiparticle-to-Particle Ratios in Au+Au Collisions at sNN=200\sqrt{s_{NN}}=200 GeV

We present ratios of the numbers of charged antiparticles to particles (pions, kaons and protons) in Au + Au collisions at $\sqrt{s_{NN}}=200$ GeV as a function of rapidity in the range $y$=0-3. While the particle ratios at midrapidity are approaching unity, the $K^-/K^+$ and $\bar{p}/p$ ratios decrease significantly at forward rapidities. An interpretation of the results within the statistical model indicates a reduction of the baryon chemical potential from $\mu_B \approx 130$MeV at $y$=3 to $\mu_B \approx 25$MeV at $y$=0.Comment: 4 pages, 4 figure

Setting ART initiation targets in response to changing guidelines : The importance of addressing both steady-state and backlog

PKBackground: Target setting is useful in planning, assessing and improving antiretroviral treatment (ART) programmes. In the past 4 years, the ART initiation environment has been transformed due to the change in eligibility criteria (starting ART at a CD4+ count <350 cells/μl v. <200 cells/μl) and the roll-out of nurse-initiated management of ART. Objective: To describe and illustrate the use of a target-setting model for estimating district-based targets in the era of an expanding ART programme and changing CD4+ count thresholds for ART initiation. Method: Using previously described models and data for annual new HIV infections, we estimated both steady-state need for ART initiation and backlog in a North West Province district, accounting for the shift in eligibility. Comparison of actual v. targeted ART initiations was undertaken. The change in CD4+ count threshold adds a once-off group of newly eligible patients to the pool requiring ART – the backlog. The steady-state remains unchanged as it is determined by the annual rate of new HIV infections in previous years. Results: The steady-state need for the district was 639 initiations/month, and the backlog was ~15 388 patients. After the shift in eligibility in September 2011, the steady-state target was exceeded over several months with some backlog addressed. Of the total backlog for this district, 72% remains to be cleared. Conclusion: South Africa has two pools of patients who need ART: the steady-state of HIV-infected patients entering the programme each year, determined by historical infection rates; and the backlog created by the shift in eligibility. The healthcare system needs to build longterm capacity to meet the steady-state need for ART and additional capacity to address the backlog

Euclidean versus hyperbolic congestion in idealized versus experimental networks

This paper proposes a mathematical justification of the phenomenon of extreme congestion at a very limited number of nodes in very large networks. It is argued that this phenomenon occurs as a combination of the negative curvature property of the network together with minimum length routing. More specifically, it is shown that, in a large n-dimensional hyperbolic ball B of radius R viewed as a roughly similar model of a Gromov hyperbolic network, the proportion of traffic paths transiting through a small ball near the center is independent of the radius R whereas, in a Euclidean ball, the same proportion scales as 1/R^{n-1}. This discrepancy persists for the traffic load, which at the center of the hyperbolic ball scales as the square of the volume, whereas the same traffic load scales as the volume to the power (n+1)/n in the Euclidean ball. This provides a theoretical justification of the experimental exponent discrepancy observed by Narayan and Saniee between traffic loads in Gromov-hyperbolic networks from the Rocketfuel data base and synthetic Euclidean lattice networks. It is further conjectured that for networks that do not enjoy the obvious symmetry of hyperbolic and Euclidean balls, the point of maximum traffic is near the center of mass of the network.Comment: 23 pages, 4 figure

Cognitive Radio Networks: Realistic or Not?

A large volume of research has been conducted in the cognitive radio (CR) area the last decade. However, the deployment of a commercial CR network is yet to emerge. A large portion of the existing literature does not build on real world scenarios, hence, neglecting various important interactions of the research with commercial telecommunication networks. For instance, a lot of attention has been paid to spectrum sensing as the front line functionality that needs to be completed in an efficient and accurate manner to enable an opportunistic CR network architecture. This is necessary to detect the existence of spectrum holes without which no other procedure can be fulfilled. However, simply sensing (cooperatively or not) the energy received from a primary transmitter cannot enable correct dynamic spectrum access. For example, the low strength of a primary transmitter's signal does not assure that there will be no interference to a nearby primary receiver. In addition, the presence of a primary transmitter's signal does not mean that CR network users cannot access the spectrum since there might not be any primary receiver in the vicinity. Despite the existing elegant and clever solutions to the DSA problem no robust, implementable scheme has emerged. In this paper, we challenge the basic premises of the proposed schemes. We further argue that addressing the technical challenges we face in deploying robust CR networks can only be achieved if we radically change the way we design their basic functionalities. In support of our argument, we present a set of real-world scenarios, inspired by realistic settings in commercial telecommunications networks, focusing on spectrum sensing as a basic and critical functionality in the deployment of CRs. We use these scenarios to show why existing DSA paradigms are not amenable to realistic deployment in complex wireless environments.Comment: Work in progres

Transverse Momentum Spectra in Au+Au and d+Au Collisions at sNN\sqrt{s_{NN}}=200 GeV and the Pseudorapidity Dependence of High pT_T Suppression

We present spectra of charged hadrons from Au+Au and d+Au collisions at $\sqrt{s_{NN}}=200$ GeV measured with the BRAHMS experiment at RHIC. The spectra for different collision centralities are compared to spectra from ${\rm p}+\bar{{\rm p}}$ collisions at the same energy scaled by the number of binary collisions. The resulting ratios (nuclear modification factors) for central Au+Au collisions at $\eta=0$ and $\eta=2.2$ evidence a strong suppression in the high $p_{T}$ region ($>$2 GeV/c). In contrast, the d+Au nuclear modification factor (at $\eta=0$) exhibits an enhancement of the high $p_T$ yields. These measurements indicate a high energy loss of the high $p_T$ particles in the medium created in the central Au+Au collisions. The lack of suppression in d+Au collisions makes it unlikely that initial state effects can explain the suppression in the central Au+Au collisions.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let