Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis

Introduction Improved nutrition is the major proven benefit of newborn screening programmes for cystic fibrosis (CF) and is associated with better clinical outcomes. It was hypothesised that early pulmonary inflammation and infection in infants with CF is associated with worse nutrition. Methods Weight, height and pulmonary inflammation and infection in bronchoalveolar lavage (BAL) were assessed shortly after diagnosis in infants with CF and again at 1, 2 and 3 years of age. Body mass index (BMI) was expressed as z-scores. Inflammatory cells and cytokines (interleukin 1b (IL-1b), IL-6, IL-8 and tumour necrosis factor a (TNFa)), free neutrophil elastase activity and myeloperoxidase were measured in BAL. Mixed effects modelling was used to assess longitudinal associations between pulmonary inflammation, pulmonary infection (Staphylococcus aureus and Pseudomonas aeruginosa) and BMI z-score after adjusting for potential confounding factors. Results Forty-two infants were studied (16 (38%) male; 39 (93%) pancreatic insufficient); 36 were diagnosed by newborn screening (at median age 4 weeks) and six by early clinical diagnosis (meconium ileus). Thirty-one (74%) received antistaphylococcal antibiotics. More than two-thirds were asymptomatic at each assessment. Mean BMI z-scores wer

Phase separation transition in liquids and polymers induced by electric field gradients

Spatially uniform electric fields have been used to induce instabilities in liquids and polymers, and to orient and deform ordered phases of block-copolymers. Here we discuss the demixing phase transition occurring in liquid mixtures when they are subject to spatially nonuniform fields. Above the critical value of potential, a phase-separation transition occurs, and two coexisting phases appear separated by a sharp interface. Analytical and numerical composition profiles are given, and the interface location as a function of charge or voltage is found. The possible influence of demixing on the stability of suspensions and on inter-colloid interaction is discussed.Comment: 7 pages, 3 figures. Special issue of the J. Phys. Soc. Ja

Optical Relay for Future NASA Geosynchronous Orbiting Satellite for High Data Rate Links to NASA User Missions

NASA is exploring options for its Next Generation Relay (NGR) architecture while the current Tracking Data Relay Satellite System (TDRSS) completes its mission. The plan is to start implementation of the NGR beginning around 2025. The new system of proposed relay satellites will greatly increase the data rates between low Earth orbiting (LEO) satellite missions and the NASA TDRSS relay satellites. This increase in data rates will allow an unprecedented increase in data throughput from the LEO satellite missions back to the principal investigators (PI). This can be accomplished at Ka-band frequencies with high order modulation or at optical frequencies using Differential Phase Shift Keying (DPSK). The first satellite in the next set of relay satellites will have to be backward compatible with current technology to support ongoing and planned missions. The new set of satellites will be launched over a 10-year period with design lifetimes of at least 15 years. To meet these requirements, we analyzed various architectures and designed both the communication payloads on the relay satellite and candidate payloads on the user spacecraft by utilizing optical heads already designed. From this analysis, a demonstration optical satellite named the Next Generation Optical Relay Pathfinder with Ka-band capabilities was proposed to be built and launched with the purpose of evaluating an integrated high-speed optical and Ka-band communication system. Given a cost limit for the demonstration satellite, various satellite configurations were developed by varying the number of optical communication payloads. The communication payload on the relay satellite consisted of three major sub-systems: 1) Optical communication payload, 2) Ka-band communication payload, 3) Digital processing and routing of signals. The size, mass (weight), and power (SWaP) of the communication payload and other sub-systems of the satellite were obtained. The NASA Glenn Research Center COMPASS team designed the Pathfinder satellite and performed a cost analysis for its build and launch. In this paper, we first describe the needs, drivers, and the associated challenges for the Next Generation Optical Relay Pathfinder to be capable of connecting multiple LEO and GEO satellites at high data rates. Second, we detail the concept of operations (ConOps) and the system architecture, including the satellite configurations considered, their attributes and limitations, and the size of the satellite needed for each configuration. Third, we provide a summary of the Next Generation Optical Relay Pathfinder satellite design trades and its key elements. Finally, we present the path needed for implementation and operations

Properties of HxTaS2

The preparation of Hx TaS2 (0 \u3c x \u3c 0.87) is described. The compounds are only marginally stable at room temperature, slowly evolving H2S and H2 (and possibly Hp in air). Magnetic susceptibility data show that a low temperature transformation in 2H ... TaS2 (at so•K) is suppressed with the addition of hydrogen, and· at the same time the superconducting transition temperature T c rises from 0.8 to ~4.2•K at x = 0.11. Heat capacity measurements near this concentration show the superconductivity to be a bulk effect. Finally, by correlation of this data with susceptibility and T c measurements in other intercalation compounds, we suggest that the rise of T c (at low electron transfer) is due to suppression of the low temperature transformation and not due to an excitonic mechanism of superconductivity

Is early center-based child care associated with tantrums and unmanageable behavior over time up to school entry?

Background. Existing research suggests that there is a relationship between greater exposure to center-based child care and child behavioral problems though the mechanism for the impact is unclear. However the measure used to document child care has usually been average hours, which may be particularly unreliable in the early months when fewer children are in center care. In addition individual trajectories for behavior difficulties have not been studied. Objective. The purpose of the current study was to examine whether the extent of exposure to center-based child care before two years predicted the trajectory of children’s difficult behavior (i.e., tantrums and unmanageable behavior) from 30 to 51 months controlling for child and maternal characteristics. Method. Data were drawn from UK-based Families, Children and Child Care (FCCC) study (n=1201). Individual growth models were fitted to test the relation between early center-based child care experiences and subsequent difficult behavior. Results. Children with more exposure to center-based care before two had less difficult behavior at 30 months, but more increase over time. Initial levels were predicted by higher difficult temperament and lower verbal ability. Higher difficult temperament and lower family socio-economic status predicted its change over time. Conclusion. Findings suggest that early exposure to center-based care before two years old is a risk factor for subsequent behavior problems especially when children have a longer period of exposure. A possible explanatory process is that child coping strategies to manage frustration are less well developed in a group context, especially when they lag behind in expressive language

Open-closed duality and Double Scaling

Nonperturbative terms in the free energy of Chern-Simons gauge theory play a key role in its duality to the closed topological string. We show that these terms are reproduced by performing a double scaling limit near the point where the perturbation expansion diverges. This leads to a derivation of closed string theory from this large-N gauge theory along the lines of noncritical string theories. We comment on the possible relevance of this observation to the derivation of superpotentials of asymptotically free gauge theories and its relation to infrared renormalons.Comment: 10 pages, LaTe

Towards magnetic slowing of atoms and molecules

We outline a method to slow paramagnetic atoms or molecules using pulsed magnetic fields. We also discuss the possibility of producing trapped particles by adiabatic deceleration of a magnetic trap. We present numerical simulation results for the slowing and trapping of molecular oxygen

Can municipality-based post-discharge follow-up visits including a general practitioner reduce early readmission among the fragile elderly (65+ years old)? A randomized controlled trial

Comparative StudyRandomized Controlled TrialThis is the final version of the article. Available from Taylor & Francis via the DOI in this record.OBJECTIVE: To evaluate how municipality-based post-discharge follow-up visits including a general practitioner and municipal nurse affect early readmission among high-risk older people discharged from a hospital department of internal medicine. DESIGN AND SETTING: Centrally randomized single-centre pragmatic controlled trial comparing intervention and usual care with investigator-blinded outcome assessment. INTERVENTION: The intervention was home visits with a general practitioner and municipal nurse within seven days of discharge focusing on medication, rehabilitation plan, functional level, and need for further health care initiatives. The visit was concluded by planning one or two further visits. Controls received standard health care services. PATIENTS: People aged 65 + years discharged from Holbæk University Hospital, Denmark, in 2012 considered at high risk of readmission. MAIN OUTCOME MEASURES: The primary outcome was readmission within 30 days. Secondary outcomes at 30 and 180 days included readmission, primary health care, and municipal services. Outcomes were register-based and analysis used the intention-to-treat principle. RESULTS: A total of 270 and 261 patients were randomized to intervention and control groups, respectively. The groups were similar in baseline characteristics. In all 149 planned discharge follow-up visits were carried out (55%). Within 30 days, 24% of the intervention group and 23% of the control group were readmitted (p = 0.93). No significant differences were found for any other secondary outcomes except that the intervention group received more municipal nursing services. CONCLUSION: This municipality-based follow-up intervention was only feasible in half the planned visits. The intervention as delivered had no effect on readmission or subsequent use of primary or secondary health care services.The Fund for Intersectoral Projects in Region Zealand, Denmark funded the project in 2011 and 2012. The funding agency had no influence on the analyses and interpretation of the results

Progress Report on the Airborne Composition Standard Variable Name and Time Series Working Groups of the 2017 ESDSWG

The role of NASA's Earth Science Data Systems Working Groups (ESDSWG) is to make recommendations relevant to NASA's Earth science data systems from users' experiences and community insight. Each group works independently, focusing on a unique topic. Progress of two of the 2017 Working Groups will be presented. In a single airborne field campaign, there can be several different instruments and techniques that measure the same parameter on one or more aircraft platforms. Many of these same parameters are measured during different airborne campaigns using similar or different instruments and techniques. The Airborne Composition Standard Variable Name Working Group is working to create a list of variable standard names that can be used across all airborne field campaigns in order to assist in the transition to the ICARTT Version 2.0 file format. The overall goal is to enhance the usability of ICARTT files and the search ability of airborne field campaign data. The Time Series Working Group (TSWG) is a continuation of the 2015 and 2016 Time Series Working Groups. In 2015, we started TSWG with the intention of exploring the new OGC (Open Geospatial Consortium) WaterML 2 standards as a means for encoding point-based time series data from NASA satellites. In this working group, we realized that WaterML 2 might not be the best solution for this type of data, for a number of reasons. Our discussion with experts from other agencies, who have worked on similar issues, identified several challenges that we would need to address. As a result, we made the recommendation to study the new TimeseriesML 1.0 standard of OGC as a potential NASA time series standard. The 2016 TSWG examined closely the TimeseriesML 1.0 and, in coordination with the OGC TimeseriesML Standards Working Group, identified certain gaps in TimeseriesML 1.0 that would need to be addressed for the standard to be applicable to NASA time series data. An engineering report was drafted based on the OGC Engineering Report template, describing recommended changes to TimeseriesML 1.0, in the form of use cases. In 2017, we are conducting interoperability experiments to implement the use cases and demonstrate the feasibility and suitability of these modifications for NASA and related user communities. The results will be incorporated into the existing draft engineering report

Probing the fuzzy sphere regularisation in simulations of the 3d \lambda \phi^4 model

We regularise the 3d \lambda \phi^4 model by discretising the Euclidean time and representing the spatial part on a fuzzy sphere. The latter involves a truncated expansion of the field in spherical harmonics. This yields a numerically tractable formulation, which constitutes an unconventional alternative to the lattice. In contrast to the 2d version, the radius R plays an independent r\^{o}le. We explore the phase diagram in terms of R and the cutoff, as well as the parameters m^2 and \lambda. Thus we identify the phases of disorder, uniform order and non-uniform order. We compare the result to the phase diagrams of the 3d model on a non-commutative torus, and of the 2d model on a fuzzy sphere. Our data at strong coupling reproduce accurately the behaviour of a matrix chain, which corresponds to the c=1-model in string theory. This observation enables a conjecture about the thermodynamic limit.Comment: 31 pages, 15 figure