R\uf6tliche L\ue4sion am Stamm

Anamnese 1 Ein 65-j\ue4hriger Patient, der im Gesichtsbereich bereits chronische Lichtsch\ue4den aufwies, wurde im Rahmen des Nierentransplantationsscreenings wegen einer neu aufgetretenen r\uf6tlichen L\ue4sion in unserer Ambulanz vorstellig. Der Patient selbst bemerkte die L\ue4sion nicht. Anamnese 2 Eine 59-j\ue4hrige Patientin kam wegen multipler N\ue4vi zur allj\ue4hrlichen Routinekontrolle. Die neu aufgetretene r\uf6tliche Papel am R\ufccken rechts war ihr nicht aufgefallen

Modulated structures in electroconvection in nematic liquid crystals

Motivated by experiments in electroconvection in nematic liquid crystals with homeotropic alignment we study the coupled amplitude equations describing the formation of a stationary roll pattern in the presence of a weakly-damped mode that breaks isotropy. The equations can be generalized to describe the planarly aligned case if the orienting effect of the boundaries is small, which can be achieved by a destabilizing magnetic field. The slow mode represents the in-plane director at the center of the cell. The simplest uniform states are normal rolls which may undergo a pitchfork bifurcation to abnormal rolls with a misaligned in-plane director.We present a new class of defect-free solutions with spatial modulations perpendicular to the rolls. In a parameter range where the zig-zag instability is not relevant these solutions are stable attractors, as observed in experiments. We also present two-dimensionally modulated states with and without defects which result from the destabilization of the one-dimensionally modulated structures. Finally, for no (or very small) damping, and away from the rotationally symmetric case, we find static chevrons made up of a periodic arrangement of defect chains (or bands of defects) separating homogeneous regions of oblique rolls with very small amplitude. These states may provide a model for a class of poorly understood stationary structures observed in various highly-conducting materials ("prechevrons" or "broad domains").Comment: 13 pages, 13 figure

Enabling Technologies for Silicon Microstrip Tracking Detectors at the HL-LHC

While the tracking detectors of the ATLAS and CMS experiments have shown excellent performance in Run 1 of LHC data taking, and are expected to continue to do so during LHC operation at design luminosity, both experiments will have to exchange their tracking systems when the LHC is upgraded to the high-luminosity LHC (HL-LHC) around the year 2024. The new tracking systems need to operate in an environment in which both the hit densities and the radiation damage will be about an order of magnitude higher than today. In addition, the new trackers need to contribute to the first level trigger in order to maintain a high data-taking efficiency for the interesting processes. Novel detector technologies have to be developed to meet these very challenging goals. The German groups active in the upgrades of the ATLAS and CMS tracking systems have formed a collaborative "Project on Enabling Technologies for Silicon Microstrip Tracking Detectors at the HL-LHC" (PETTL), which was supported by the Helmholtz Alliance "Physics at the Terascale" during the years 2013 and 2014. The aim of the project was to share experience and to work together on key areas of mutual interest during the R&D phase of these upgrades. The project concentrated on five areas, namely exchange of experience, radiation hardness of silicon sensors, low mass system design, automated precision assembly procedures, and irradiations. This report summarizes the main achievements

Chapter X: The Tour de France: a success story in spite of competitive imbalance and doping

International audienceThe chapter goes as follows. In the first section it is demonstrated how the Tour de France is a high quality product. This is a result from its accurate design, its management, its economic model and its finance structure, both in comparison to other mega-sporting events and with reference to tournament theory. It is not easy to assess the competitive balance in the Tour de France since, as was demonstrated in chapter 10, it is at the same time an individual and a team sport contest. After reviewing some results published in literature so far, a new metrics for evaluating competitive balanced in the Tour de France is presented in section 2. Finally, the Tour de France cannot ignore doping as a potential threat to fan attendance and TV viewing. We therefore discuss the issue of doping and a new procedure to deal with doping in section 3

Protein deficiency balance as a predictor of clinical outcome in hereditary spherocytosis

Vertical and horizontal interactions between membrane constituents account for integrity, strength and deformability of the erythrocyte. Disruption of vertical interactions caused by membrane protein deficiencies in hereditary spherocytosis (HS), favor membrane vesiculation with development of spherocytic cells. Our aim was to evaluate the hematological and clinical presentation of HS according to the type and amount of protein deficiency. We studied 81 Portuguese individuals, 71 belonging to 21 families plus 10 unrelated subjects, and found that 51 of them were HS patients. Patients were classified as presenting mild, typical or severe HS, according to laboratory results and clinical follow-up. We performed screening tests and the standardized electrophoretic membrane protein analysis to identify and quantify protein deficiencies. We found band 3 and ankyrin deficiencies as the major causes for HS. The ratios between the value of the primary and/or secondary protein deficiencies showed significantly different values according to the severity of HS, and a significant inverse correlation with the severity of HS was observed. In mild HS, the ratios between protein deficiencies reflected equivalent protein deficiencies, while an unbalance was observed in typical HS, which was enhanced in severe HS. Our data suggest that the relative quantification of each major membrane protein and of the ratios between the values of protein deficiencies may be helpful in providing additional data about the clinical outcome of HS

The role of nicotinamide in acne treatment

Safe and effective treatment options for acne vulgaris are needed to address side effects and increasing rates of antibiotic resistance from current treatments. Nicotinamide is a vitamin with potent antiâ inflammatory properties that could offer a potential treatment option. We aim to summarize the relevant literature on the role of nicotinamide in acne vulgaris and discuss the next steps necessary to move this approach into clinical practice. We searched PubMed for clinical studies using nicotinamide for treatment of acne vulgaris. We summarized the 10 studies that met our search criteria. Six of eight studies using topical nicotinamide led to a significant reduction in acne compared with the patient’s baseline or performed similarly to another standardâ ofâ care acne treatment. Both studies using an oral supplement containing nicotinamide resulted in a significant reduction in acne compared with baseline. No major adverse side effects were noted. Our review suggests that topical and oral nicotinamide has an unclear effect on acne vulgaris due to the limited nature of the available literature. Additional studies are needed comparing nicotinamide to other firstâ line acne treatments and evaluating the efficacy and side effect profile of nicotinamide over an extended period of time.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138875/1/dth12481_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138875/2/dth12481.pd

Ultra-broadband UV/VIS spectroscopy enabled by resonant dispersive wave emission of a frequency comb

We introduce an agile light source bridging from the near ultraviolet to the visible spectral region by covering more than 240 THz through resonant dispersive wave (RDW) emission in a gas-filled hollow-core fiber waveguide. The light source allows tuning of a 20 nm (FWHM) spectrum from ∼340 nm to 465 nm (645 to ∼885 THz) with conversion efficiencies of (1.5 ± 0.4) %, providing spectral powers up to (2.6 ± 1) mW/nm. This technique is showcased for spectroscopy with broadband absorption measurements of nitrogen dioxide, a molecular species of major atmospheric relevance. To our knowledge, this is the first demonstration of absorption spectroscopy with an RDW-based light source. The presented measurements indicate conservation of the coherence of the frequency comb seeding the frequency up-conversion process, paving the way towards ultra-broadband (dual) comb molecular spectroscopy across the highly relevant ultraviolet and visible range

The use of pediatric flexible bronchoscopy in the COVID-19 pandemic era

On March 11, 2020, the World Health Organization (WHO) declared the pandemic because of a novel coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In January 2020, the first transmission to healthcare workers (HCWs) was described. SARS-CoV-2 is transmitted between people because of contact, droplets, and airborne. Airborne transmission is caused by aerosols that remain infectious when suspended in air over long distances and time. In the clinical setting, airborne transmission may occur during aerosol generating procedures like flexible bronchoscopy. To date, although the role of children in the transmission of SARS-CoV-2 is not clear the execution of bronchoscopy is associated with a considerably increased risk of SARS-CoV-2 transmission to HCWs. The aim of this overview is to summarize available recommendations and to apply them to pediatric bronchoscopy. We performed systematic literature searches using the MEDLINE (accessed via PubMed) and Scopus databases. We reviewed major recommendations and position statements published at the moment by the American Association for Bronchology and Interventional Pulmonology, WHO, European Center for Disease Prevention and Control and expert groups on the management of patients with COVID-19 to limit transmission among HCWs. To date there is a lack of recommendations for safe bronchoscopy during the pandemic period. The main indications concern adults and little has been said about children. We have summarized available recommendations and we have applied them to pediatric bronchoscopy

Rodents in Xerophilous Shrubland and SemiDesert Grassland Communities of Southeastern Coahuila, Mexico

Objective: To assess the diversity of rodent communities in semi-desert grasslands and xerophilous shrubland at the “Los Ángeles” Ranch in southeastern Coahuila. Design/methodology/approach: Monthly samplings were carried out from May to November 2020 using Sherman traps. The capture-recapture method was used to estimate species richness and abundance. Nonparametric estimators, species rarefaction curves, and rank abundance plots were utilized to measure species diversity. The Whittaker index was employed to assess species turnover between sampled communities. Results: A total of 205 individuals from three families and eight species of rodents were recorded, with the Cricetidae family being the best represented. The species rarefaction curve showed that the shrubland exhibited greater diversity compared to the grassland. The dominant species were Onychomys arenicola in the semi-desert grassland and Peromyscus zamorae in the xerophilous shrubland. Limitations/implications: There remains a need to extend long-term monitoring efforts to detect how anthropogenic activities influence species composition. Findings/conclusions: The study highlights the importance of grasslands for the conservation of rodents in the state. Semi-desert grasslands and shrublands provide natural resources that should be preserved to maintain biodiversity in semi-arid ecosystems