EFEK INTERVENSI TRAINING DAN COACHING KEBERMAKNAAN KERJA TERHADAP KINERJA KARYAWAN: THE EFFECT OF MEANINGFUL WORK TRAINING AND COACHING INTERVENTION ON EMPLOYEE PERFORMANCE

This study aims to determine the extent of meaningful work interventions in the form of training and coaching can improve room attendant’s performance (housekeeping department) at Bumi Surabaya City Resort. The research was conducted by the action research method with three stages namely Pre ODI (Diagnosis), ODI (Design and Implementation), and Post ODI (Expected Outcome). ODI itself stands for Organization Development Intervention, which means a structured program designed to solve problems, thereby enabling organizations to achieve goals. Based on Pre ODI results, room attendants have low performance because room attendants do not yet understand the purpose and meaning of their work. Therefore at the ODI stage, researchers provide meaningful work interventions with tools in the form of training and coaching to improve employee performance. To see an improvement in employee performance, the Post ODI researchers conducted a different test (Paired Sample T-Test) before and after the intervention. The results showed that meaningful work training and coaching intervention were able to increase employee performance scores from 3,03 (Pre ODI) to 3,43 (Post ODI). Thus, the research hypothesis can be accepted that there are differences in the average employee performance scores before and after the intervention. Keywords: coaching, employee performance, meaningful work, organization development intervention, trainin

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Plan de negocios para una cl?nica oftalmol?gica pedi?trica en Lima

El presente Plan de Negocio tiene como objetivo analizar y sustentar la viabilidad t?cnica financiera para la implementaci?n de una Cl?nica Oftalmol?gica Pedi?trica en Lima. Nace la idea de crear un modelo de negocio orientado a brindar un servicio con excelencia, calidad y tecnolog?a, dirigido a los sectores A y B de la poblaci?n de Lima Metropolitana

La influencia de la gesti?n del conocimiento en el desempe?o financiero: el rol mediador de la innovaci?n

En el mercado competitivo moderno, se puede argumentar que solo aquellas empresas que generen nuevo conocimiento ser?n las que tengan ?xito. Bajo esta premisa, la gesti?n del conocimiento se vuelve esencial; sin embargo, se han identificado pocos estudios que eval?en como este factor termina aportando a la generaci?n de resultados financieros. Es por ello que el presente estudio de investigaci?n propone un modelo te?rico que explique la influencia de la gesti?n del conocimiento en el desempe?o financiero, estableciendo a la innovaci?n como variable mediadora de esta relaci?n. Adicionalmente, se incorporan al modelo los factores organizacionales y del entorno como variables moderadoras de la relaci?n innovaci?n desempe?o. Se espera contribuir de forma te?rica acotando la brecha en el conocimiento, brindando una mayor claridad sobre la relaci?n de las variables mencionadas y, asimismo, se espera establecer diversas implicancias a nivel pr?ctico para empresarios y administradores, al poder justificar el desarrollo de la gesti?n del conocimiento basado en el incremento del desempe?o financiero. Con respecto a la recopilaci?n de datos se sugiere emplear encuestas como instrumento de medici?n. Para el procesamiento de la informaci?n, se propone realizar el an?lisis de los datos empleando la t?cnica estad?stica de regresi?n m?ltiple

The impact of preoperative oral nutrition supplementation on outcomes in patients undergoing gastrointestinal surgery for cancer in low- and middle-income countries:a systematic review and meta-analysis

Abstract Malnutrition is an independent predictor for postoperative complications in low- and middle-income countries (LMICs). We systematically reviewed evidence on the impact of preoperative oral nutrition supplementation (ONS) on patients undergoing gastrointestinal cancer surgery in LMICs. We searched EMBASE, Cochrane Library, Web of Science, Scopus, WHO Global Index Medicus, SciELO, Latin American and Caribbean Health Sciences Literature (LILACS) databases from inception to March 21, 2022 for randomised controlled trials evaluating preoperative ONS in gastrointestinal cancer within LMICs. We evaluated the impact of ONS on all postoperative outcomes using random-effects meta-analysis. Seven studies reported on 891 patients (446 ONS group, 445 control group) undergoing surgery for gastrointestinal cancer. Preoperative ONS reduced all cause postoperative surgical complications (risk ratio (RR) 0.53, 95% CI 0.46–0.60, P < 0.001, I 2 = 0%, n = 891), infection (0.52, 0.40–0.67, P = 0.008, I 2 = 0%, n = 570) and all-cause mortality (0.35, 0.26–0.47, P = 0.014, I 2 = 0%, n = 588). Despite heterogeneous populations and baseline rates, absolute risk ratio (ARR) was reduced for all cause (pooled effect −0.14, −0.22 to −0.06, P = 0.006; number needed to treat (NNT) 7) and infectious complications (−0.13, −0.22 to −0.06, P < 0.001; NNT 8). Preoperative nutrition in patients undergoing gastrointestinal cancer surgery in LMICs demonstrated consistently strong and robust treatment effects across measured outcomes. However additional higher quality research, with particular focus within African populations, are urgently required

BCLA CLEAR presbyopia: Management with scleral techniques, lens softening, pharmaceutical and nutritional therapies

The aging eye undergoes the same progressive crosslinking which occurs throughout the body, resulting in increased rigidity of ocular connective tissues including the lens and the sclera which impact ocular functions. This offers the potential for a scleral treatment that is based on restoring normal biomechanical movements. Laser Scleral Microporation is a laser therapy that evaporates fractional areas of crosslinked tissues in the sclera, reducing ocular rigidity over critical anatomical zones of the accommodation apparatus, restoring the natural dynamic range of focus of the eye. Although controversial and challenged, an alternative theory for presbyopia is Schachar's theory that suggests a reduction in the space between the ciliary processes and the crystalline lens. Widening of this space with expansion bands has been shown to aid near vision in people with presbyopia, a technique that has been used in the past but seems to be obsolete now. The use of drugs has been used in the treatment of presbyopia, either to cause pupil miosis to increase depth of focus, or an alteration in refractive error (to induce myopia in one eye to create monovision). Drugs and laser ablation of the crystalline lens have been used with the aim of softening the hardened lens. Poor nutrition and excess exposure to ultraviolet light have been implicated in the onset of presbyopia. Dietary nutritional supplements, lifestyle changes have also been shown to improve accommodation and the question arises whether these could be harnessed in a treatment for presbyopia as well

Mediator Acts Upstream of the Transcriptional Activator Gal4

We show that Mediator, a protein originally isolated on the basis of its ability to respond to transcriptional activators, and thought to be regulated by an activator, can also be the master that controls the activator

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance. Bacterial persistence occurred in granulomas enriched for mast, endothelial, fibroblast, and plasma cells, signaling amongst themselves via type 2 immunity and wound-healing pathways. Granulomas that drove bacterial control were characterized by cellular ecosystems enriched for type 1-type 17, stem-like, and cytotoxic T cells engaged in pro-inflammatory signaling networks involving diverse cell populations. Granulomas that arose later in infection displayed functional characteristics of restrictive granulomas and were more capable of killing Mtb. Our results define the complex multicellular ecosystems underlying (lack of) granuloma resolution and highlight host immune targets that can be leveraged to develop new vaccine and therapeutic strategies for TB

Quantum-centric supercomputing for materials science: A perspective on challenges and future directions

Computational models are an essential tool for the design, characterization, and discovery of novel materials. Computationally hard tasks in materials science stretch the limits of existing high-performance supercomputing centers, consuming much of their resources for simulation, analysis, and data processing. Quantum computing, on the other hand, is an emerging technology with the potential to accelerate many of the computational tasks needed for materials science. In order to do that, the quantum technology must interact with conventional high-performance computing in several ways: approximate results validation, identification of hard problems, and synergies in quantum-centric supercomputing. In this paper, we provide a perspective on how quantum-centric supercomputing can help address critical computational problems in materials science, the challenges to face in order to solve representative use cases, and new suggested directions