Rejection Sensitivity, Perceived Power, and HIV Risk in the Relationships of Low-Income Urban Women

The psychological processes associated with HIV infection in long-term relationships differ from those operative in casual sexual encounters, and relatively little research has considered the aspects of personality applicable in the ongoing heterosexual relationships in which women are at greatest risk. Sensitivity to rejection has been linked with efforts to prevent rejection at a cost to the self and, therefore, may be relevant to the health risks that many women incur in relationships. We examined the association of rejection sensitivity with women\u27s sexual risk behavior in a sample of women at heightened risk for HIV exposure. Women in long-term heterosexual relationships (N = 159) were recruited for study participation in the hospital emergency room serving a low-income neighborhood in New York City, in 2001-2003. Rejection sensitivity and known HIV risk factors were assessed using verbally administered questionnaires. Rejection sensitivity was associated with lower perceived relationship power and, in turn, more frequent unprotected sex with a partner perceived to be at risk for HIV. These results held when controlling for other HIV risk factors including partner violence, economic dependence, and substance use. Understanding the association of rejection concerns with lower perceived personal power in relationships may be important for HIV prevention

Psychological Distress and Intimate Physical and Sexual Abuse among Women in Methadone Maintenance Treatment Programs

Guided by the cognitive theory of stress and coping and the comprehensive health“seeking and coping paradigm, this study examines associations among intimate partner abuse and psychological distress, posttraumatic stress disorder, childhood sexual abuse, and current drug use among a cohort of 416 women randomly recruited from New York City methadone treatment programs. Findings expand on past evidence of the high prevalence of psychological distress among adult victimized women and among those with a history of childhood sexual abuse. Women currently abused by their partners have more posttraumatic stress symptoms, depression, and psychological distress than women not abused by their partners

Disability Among Women Workers and the Role of Social Support Systems

The study examined factors affecting return to work following a short-term disability and measured the relationship between social support and the subject's well-being status, emphasizing the role of the social support system. Subjects are 185 female city workers, members of District Council 37, AFSCME, AFL-CIO, and recently either physically or mentally disabled. They are entitled to a maximum of six-months short-term disability benefits. Data, collected through a structured telephone interview, included the Arizona Social Support Interview Schedule (ASSIS), modified to the type of event (short-term disability), population (female), to measure perceived social support, and the General Well-Being Schedule to measure subjects' well-being. Univariate and multivariate statistical techniques were utilized. Six variables predicted length of unemployment: (1) severity of illness; (2) general well-being; (3) type of disability (physical or mental); (4) quality of support from immediate family; (5) job tenure; and (6) perceived financial stress. None of the work social support variables were statistically significant in predicting length of unemployment. A relationship between social support and well-being was found. Four variables predicted the subject's well-being status: (1) perceived financial stress; (2) job satisfaction; (3) quality of support from family; and (4) quality of support from friends. Mentally disabled subjects remained longer on short-term disability than the physically disabled and a higher percentage were unemployed at the end of the six-month short-term disability, implying that they are at a greater risk of leaving the labor force. Findings are consistent with existing research on the role of social support in promoting well-being and return to work, as well as identification of critical risk factors for leaving the labor force. These have critical implications for social work practice and policy, in general, and in union settings

Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data

Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan

Implications of Mobility Patterns and HIV Risks for HIV Prevention Among Migrant Market Vendors in Kazakhstan

Objectives. We examined the relationships between mobility characteristics and sexual risk behaviors among male and female migrant market vendors in Almaty, Kazakhstan. Methods. Participants completed a structured interview covering sociodemographics, mobility characteristics, sexual behaviors, and biomarkers for HIV, HCV, and syphilis. We used multivariate analyses to examine associations between mobility patterns and HIV risks after adjusting for sociodemographics. Results. Longer duration of a participant's last trip outside Almaty increased the odds of reporting multiple sexual partners. More frequent travel to visit family or friends was associated with multiple sexual partners and unprotected sex with steady partners. More frequent travel to buy goods in the past year was associated with multiple sexual partners. Men who traveled more often to buy goods were more likely to have purchased sex within the previous 90 days. Conclusions. Relationships between mobility patterns and sexual risk behaviors underscore the need for HIV-prevention strategies targeting the specific transmission dynamics that migrant vendors are likely to present

Small molecule tyrosine kinase inhibitors in pancreatic cancer

Pancreatic cancer has proven to be chemo-resistant, with gemcitabine being the only cytotoxic agent approved for advanced pancreatic cancer since 1996. Tyrosine kinase inhibitors represent a newer generation of chemotherapeutic agents targeting specific tumor pathways associated with carcinogenesis including cell cycle control, signal transduction, apoptosis and angiogenesis. These agents present a more selective way of treating pancreatic cancer. Erlotinib is the prototype of the tyrosine kinase inhibitors with proven efficacy in advanced pancreatic cancer and has been recently approved in that setting. Multiple other tyrosine kinase inhibitors targeting the VEGFR, PDGFR, and Src kinases are in various phases of clinical trials testing. The preliminary results of these trials have been disappointing. Current challenges in pancreatic cancer clinical trials testing include improving patient selection, identifying effective combinations, improving the predictive value of current preclinical models and better study designs. This review summarizes the present clinical development of tyrosine kinase inhibitors in pancreatic cancer and strategies for future drug development

Population Descent: A Natural-Selection Based Hyper-Parameter Tuning Framework

First-order gradient descent has been the base of the most successful optimization algorithms ever implemented. On supervised learning problems with very high dimensionality, such as neural network optimization, it is almost always the algorithm of choice, mainly due to its memory and computational efficiency. However, it is a classical result in optimization that gradient descent converges to local minima on non-convex functions. Even more importantly, in certain high-dimensional cases, escaping the plateaus of large saddle points becomes intractable. On the other hand, black-box optimization methods are not sensitive to the local structure of a loss function's landscape but suffer the curse of dimensionality. Instead, memetic algorithms aim to combine the benefits of both. Inspired by this, we present Population Descent, a memetic algorithm focused on hyperparameter optimization. We show that an adaptive m-elitist selection approach combined with a normalized-fitness-based randomization scheme outperforms more complex state-of-the-art algorithms by up to 13% on common benchmark tasks

Lze nepříznivým komplikacím peroneální parézy předejít implantací endoprotézy: návrh a vývoj prototypu implantátu

Can the adverse complications of foot drop be prevented by an endoprosthesis: design and development of a prototype device Abstract Foot drop is a very old problem since Jacob from the bible was limping when he was wrestling with the angels. Foot drop occurs very often, and it is a very common condition in trauma, after surgery, and neurological diseases. The aim of this project is to identify an endo-prosthesis and test it bio-mechanically and bio- medically in order to resolve the problem. This endo-prosthesis must improve the quality of life for patients suffering from foot drop due to the injury to the common peroneal nerve. The device that must be created should be small and surgically will be attached to the muscle internally and work as if the muscles and nerve were intact. The device would be tested outside the human body. It is important to throw light on that the device should be made of a material that is accepted by the human body and should have a stiffness that is close to the weight of the foot to ensure a normal motion. The intent of this bio-mechanical device is to help patients suffering from foot drop to restore normal motion. An endo-prosthesis that is implanted in the foot might be the solution to foot drop disease. The endo-prosthesis has a major role to do the opposite movement and...Department of OrthopaedicsKlinika dětské a dospělé ortopedie a traumatologieSecond Faculty of Medicine2. lékařská fakult