Scintigraphy with 99mTc-HMPAO labeled leukocytes is still an accurate and convenient tool to rule out suspected inflammatory bowel disease in children

BACKGROUND: Abdominal pain is a common complaint in children and its differential diagnosis includes inflammatory bowel disease (IBD). The aim of the study was to assess the diagnostic accuracy of scintigraphy with 99mTechnetium Hexamethylpropyleneamine Oxime (99mTc-HMPAO) labeled leukocytes in children with suspected IBD. MATERIAL AND METHODS: Eighty-five children (age 12.4 ± 4.3 years, 47% boys) with suspected IBD based on clinical presentation, laboratory and ultrasound findings underwent scintigraphy with 99mTc-HMPAO labeled leukocytes. Abdominal scintigrams were acquired 40 min and 90 min post injection, and whole body scintigrams at 180 min. Scintigraphy was evaluated by two specialists in nuclear medicine. The results were compared with the final diagnosis established by endoscopy, histology, other imaging methods, and follow-up evaluated by an expert in pediatric gastroenterology. RESULTS: Scintigraphy results corresponded with the final diagnosis in 78 (91%) patients resulting in a sensitivity of 89% (95%CI 72 to 98%), specificity of 91% (95% CI 82 to 98%), and accuracy of 91% (95% CI 83 to 96%). The interobserver agreement was 0.82 (95% CI 0.75 to 0.88) and the radiation dose estimate was 4.2 ± 1.5 mSv. In 28 children (25 positives and 3 negatives on scintigraphy), the diagnosis of IBD was established by endoscopy, histology, MR enterography, or fluoroscopy. Five positive findings on scintigraphy were not confirmed by other methods or during follow-up. CONCLUSION: Scintigraphy with 99mTc-HMPAO labeled leukocytes in children with suspected IBD has high accuracy and offers a non-invasive option for detecting the presence of gastrointestinal inflammation. Scintigraphy is a powerful non-invasive decision-making tool in the management of suspected IBD that may spare a greater proportion of children of more invasive and demanding examinations

Reporting of funding and conflicts of interest improved from preprints to peer-reviewed publications of biomedical research

Background and Objectives: To assess changes in the reporting of funding and conflicts of interest (COI) in biomedical research between preprint server publications and their corresponding versions in peer-reviewed journals. Methods: We selected preprint servers publishing exclusively biomedical research. From these, we screened articles by order of publication date and identified 200 preprints first published in 2020 with subsequent versions in peer-reviewed journals. We judged eligibility and extracted data about authorship, funding, and COI in duplicate and independently. We performed descriptive statistics. Results: A quarter of the studies added at least one author to the peer-reviewed version. Most studies reported funding in both versions (87%), and a quarter of these added at least one funder to the peer-reviewed version. Eighteen studies (9%) reported funding only in the peer-reviewed version. A majority of studies reported COI in both versions (69%) and 5% of these had authors reporting more COI in the peer-reviewed version. A minority of studies (23%) reported COI only in the peer-reviewed version. None of the studies justified any changes in authorship, funding, or COI. Conclusion: Reporting of funding and COI improved in peer-reviewed versions. However, substantive percentages of studies added authors, funders, and COI disclosures in their peer-reviewed versions. © 2022 Elsevier Inc

Low-viscosity Composite Filling Materials as an Alternative in Treating Cervical Defects

The author in his present study focuses on the behavior of cervical fillings created using the lowviscosity composite filling material Tetric® Flow in combination with the 6th generation, no-mix, self-etching adhesive system AdheSE®. The treated defects were of both carious and non-carious origin.The study was performed on the total number of 29 patients, 10 males and 19 females with both carious and non-carious cervical lesions. The total number of 79 cervical defects was treated during the year 2002. Thirty of those defects were of carious origin and 49 of non-carious origin. The fillings were then periodically observed once a year up to 2006.The total survival rate of those fillings after 4 years was 86.7% in case of carious cervical lesions and 93.3% in case of non-carious cervical lesions. The rest of the observed modified USPHS criteria were, with two exceptions, significantly better in case of non-carious defects.Low-viscosity composite filling materials seem to be a good choice in treating cervical defects

The possibilities of treating cervicals defects

Department of DentistryStomatologická klinikaLékařská fakulta v Hradci KrálovéFaculty of Medicine in Hradec Králov

Methods of log interpretations in the Jeribe formation of Syrian Jbisa oil-field

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