1,333 research outputs found

    Adaptive undivided wheel opener

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    Adaptive undivided wheel opener is a special purpose tool used to tighten and loosen all the nuts of wheel at the same time with less effort. It uses bevel gear assembly for transmitting torque to the nuts and lock – nut arrangement have been used to make the system adjustable to the required pitch length. The most desired advantage is that the total time consumed in the process is very less. It can open and refit the wheel with same tool. Tool is simple in design and easily portable along with vehicle

    Tolkappiya Meyppatukalin ullitukalum Natrinai Mantarin ulaviyalum

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    Tholkappiyam is the most ancient extent Tamil grammer text and the oldest extant long work of Tamil Literature. The surviving manuscripts of the Tholka ppiyam consists of three books each with nine chapters namely Eluthu, Chol and porul. Among the nine chapters in porul, Maippattiyal is one of the above nine. It is named thus in view of the fact that it expounds the feelings and emotions.  The scholars will say the eight states of being beginning with Nagai, Azukai, ilivaral, Marutkkai, Acham, Perumitham, Vekuli, uvakai are the basic eight categories of Meyppadu. This Article Compares the above eight categories with Natrinai is a book of Ettuthogai a Sangam literature anthology. This belongs to Sangam Poetry of the oldest extant Tamil Literature

    Sahitya Akademi Award Winning ‘Gopalla Gramam’ - An Information Repository

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    The purpose of this article is to explore the disappearing uniqueness in Rajanarayana's Sahitya Academy Award-winning novel Gopalla Gramam. It is said to be a novel. But there is no complete storytelling in this novel that is unique to a novel. So no specific characters were found. There is no continuous sequel in the storytelling process. However, it has acquired the unique status that a novel deserves. A lot of people exist in this. A lot of incidents do happen. The novel is considered to be a wonderful work that contains a lot of information and traces of time. The characters in this novel have every kind of relevance. The novel also explores the lifestyles and customs of different types of people, both socially and individually. It has also recorded social issues. Many colloquialisms that have been in circulation at that time are recorded. On the whole, the purpose of this article is to explore the availability of Ki Ra’s ‘Gopalla Gramam’ as an information repository

    The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.

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    p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and Mdm2. In this study, we show that knockdown of the proteasomal ubiquitin receptor S5a/PSMD4/Rpn10 inhibits p53 protein degradation and results in the accumulation of ubiquitinated p53. Overexpression of a dominant-negative deletion of S5a lacking its ubiquitin-interacting motifs (UIM)s, but which can be incorporated into the proteasome, also causes the stabilization of p53. Furthermore, small-interferring RNA (siRNA) rescue experiments confirm that the UIMs of S5a are required for the maintenance of low p53 levels. These observations indicate that S5a participates in the recognition of ubiquitinated p53 by the proteasome. In contrast, targeting S5a has no effect on the rate of degradation of Mdm2, indicating that proteasomal recognition of Mdm2 can be mediated by an S5a-independent pathway. S5a knockdown results in an increase in the transcriptional activity of p53. The selective stabilization of p53 and not Mdm2 provides a mechanism for p53 activation. Depletion of S5a causes a p53-dependent decrease in cell proliferation, demonstrating that p53 can have a dominant role in the response to targeting S5a. This study provides evidence for alternative pathways of proteasomal recognition of p53 and Mdm2. Differences in recognition by the proteasome could provide a means to modulate the relative stability of p53 and Mdm2 in response to cellular signals. In addition, they could be exploited for p53-activating therapies. This work shows that the degradation of proteins by the proteasome can be selectively dependent on S5a in human cells, and that this selectivity can extend to an E3 ubiquitin ligase and its substrate

    Effect of yogic practices on selected physiological variables among hypertensive middle-aged women

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    The purpose of the random group experimental study was to investigate the effect of Yogic Practices on selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) among Hypertensive middle aged women. It was hypothesized that there would be a significant difference due to Yogic Practices on selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) among Hypertensive middle-aged women than the control group. Random group experimental design was used. The random sampling design was followed to select the subjects. To achieve the purpose of the study, 30 women between the age 45 and 55 years were selected randomly from Chennai and they were divided into two groups such as Yogic Practices (Group A) and Control Group (Group B). Each group consists of 15 subjects. The pre-test was taken for the two Groups on the selected dependent variables before the start of the training program. Group A was undergoing Yogic Practices for 12weeks, 6 days a week, One-hour maximum daily and Group B (Control Group) was permitted to undergo their normal lifestyle (active rest) during the course of the experiment. After the experimental period of 12 weeks, Post-tests were conducted for the two groups on selected dependent variables. The selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) were measured through Lab test. Analysis of Co-Variance (ANCOVA) was used to find out the significant difference between experimental group and the Control Group. The test of significance was fixed at 0.05 level of confidence. It was concluded that Yogic Practices improved Physiological variables among Hypertensive middle-aged women than the Control Group. Hence, the hypothesis was accepted at 0.05 level of confidence

    Comparison of Surface Roughness Prediction with Regression and Tree Based Regressions During Boring Operation

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    Modern manufacturing methods permit the study and prediction of surface roughness since the acquisition of signals and its processing is made instantaneously. With the availability of better computing facilities and newer algorithms in the machine learning domain, online surface roughness prediction will lead to the manufacture of intelligent machines that alert the operator when the process crosses the specified range of roughness. Prediction of surface roughness by multiple linear regression, regression tree and M5P tree methods using multivariable predictors and a single response dependent variable Ra (surface roughness) is attempted. Vibration signal from the boring operation has been acquired for the study that predicts the surface roughness on the inner face of the workpiece. A machine learning approach was used to extract the statistical features and analyzed by four different cases to achieve higher predictability, higher accuracy, low computing effort and reduction of the root mean square error. One case among them was carried out upon feature reduction using Principle Component Analysis (PCA) to examine the effect of feature reduction

    Defects in Friction Stir Welding of Steel

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    Defects associated with friction stir welding of two steel grades including DH36 and EH46 were investigated. Different welding parameters including tool rotational and tool traverse (linear) speeds were applied to understand their effect on weld seam defects including microcracks and voids formation. SEM images and infinite focus microscopy were employed to identify the defects types. Two new defects associated with the friction stir welding process are introduced in this work. The first defect identified in this work is a microcrack found between the plunge and the steady state region and attributed to the traverse moving of the tool with unsuitable speed from the plunge-dwell to the steady state stage. The tool traverse speed has recommended to travel 20 mm more with accelerated velocity range of 0.1 from the maximum traverse speed until reaching the steady state. The maximum recommended traverse speed in the steady state was also suggested to be less than 400 mm/min in order to avoid the lack in material flow. The second type of defect observed in this work was microcracks inside the stirred zone caused by elemental precipitations of TiN. The precipitates of TiN were attributed to the high tool rotational speed which caused the peak temperature to exceed 1200 °C at the top of the stirred zone and based on previous work. The limit of tool rotational speed was recommended to be maintained in the range of 200-500 RPM based on the mechanical experiments on the FSW samples

    Becnh Mark Study on The Use of Computational Fluid Dynamics for Marine Application

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    Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv
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