203 research outputs found
Sensors data collection framework using mobile identification with secure data sharing model
Sensors are the modules or electronic devices that are used to measure and get environmental events and send the captured data to other devices, usually computer processors allocated on the cloud. One of the most recent challenges is to protect and save the privacy issues of those sensors data on the cloud sharing. In this paper, sensors data collection framework is proposed using mobile identification and proxy re-encryption model for data sharing. The proposed framework includes: identity broker server, sensors managing and monitoring applications, messages queuing sever and data repository server. Finally, the experimental results show that the proposed proxy re-encryption model can work in real time
Assessing the Role of Water Users Associations in Operating and Maintaining the Improved Irrigation System in Egypt
The current study investigated the influence of Water Users Associations (WUAs) in the operation and the maintenance of the facilities of improved areas in Egypt. With the establishment of irrigation improvement projects, it was planned that WUAs would play an important role in improving water management and ensuring the sustainability of the improved system through enhancing the cooperation between farmers, scheduling the irrigation and maintaining the improved Mesqas (distributaries). The current study aims to check the actual situation after the implementation of irrigation improvement projects through collecting data from samples according to design questionnaires in the improved areas, and analyzing the collected data to investigate the influence of these associations. The results showed that the influence of WUAs in Egypt was still very limited. Irrigation practices were close to the old trend, which was targeting by irrigation improvement projects. The improved system was operated based on the natural relationships between farmers, with no predefined irrigation schedule targeting improving water management. The operator was the main person, and his role was just to arrange the irrigation based on the reservation of the farmers. Old lifting points were still used in the new system. This gave the farmers the chance to work individually, which could decrease the direct conflicts between them, but it had negative impact on water use efficiency. The maintenance of the system was poor, and the target was just to make the system work without considering the sustainability of the system. The study discussed the reasons behind the weak influence of WUAs including the characteristics of such organizations and different factors that affect their performance. In addition, the study suggested the required steps to improve the capacities of these organizations and to enhance the coordination between farmers including the precise distribution of water supply, and the support from the government
Who are the Users of Speed Regulation Assistance? Comparing Driver Characteristics of Casual and Intensive System Users
Speed regulation assistance can contribute to road safety provided that drivers use the systems on a regular basis. With the objective to gain knowledge about drivers who use Cruise Control and the Speed Limiter, a comparison of the characteristics of casual and intensive users was performed with survey data. The results show that gender and annual mileage play a role for the usage frequency of Cruise Control, whereas the usage frequency of the Speed Limiter depends on age. Consistent effects of the car use for business matters and the use of other invehicle technologies were found on the usage frequency of both systems. The predominant motive to reduce speeding found for both systems corresponds with the objective of speed regulation assistance as a safety measure. It was complemented with a comfort benefit perceived by Cruise Control users
Enveloping Sophisticated Tools into Process-Centered Environments
We present a tool integration strategy based on enveloping pre-existing tools without source code modifications or recompilation, and without assuming an extension language, application programming interface, or any other special capabilities on the part of the tool. This Black Box enveloping (or wrapping) idea has existed for a long time, but was previously restricted to relatively simple tools. We describe the design and implementation of, and experimentation with, a new Black Box enveloping facility intended for sophisticated tools --- with particular concern for the emerging class of groupware applications
Porous beta titanium alloy coated with a therapeutic biopolymeric composite to improve tribomechanical and biofunctional balance
Tooth loss is common in patients struggling with dental cavities, periodontal diseases, and tumors, as well as those
who abuse tobacco or drugs. In this scenario, dental implants have become the primary treatment option for
complete or partial tooth loss. Dental implant failure can be caused by stress shielding phenomenon, poor
osseointegration, or to bacterial infections. In the present study, a joint solution to these limitations is proposed
using a variety of porous β-titanium substrates using powder Ti35Nb7Zr5Ta alloy and employing the spacer-holder
approach (ammonium bicarbonate) to obtain a variety of porosity percentage (30, 40, and 50 vol%), and pore
diameters in 100–200 μm, that has been characterized in terms of its size distribution, density, morphology,
chemical composition, compaction ability and Vickers micro-hardness. Furthermore, porosity, microstructure
(Archimedes and image analysis) and tribomechanical behavior (P-h curves and scratch tests) experiments were
performed to study and characterize the porous substrates. Polyvinyl alcohol (PVA)/poly-ε-caprolactone (PCL)
containing silver nanoparticles (AgNPs), as antibacterial composite, was employed to infiltrate β-Ti disks. Scanning
electron microscopy was used to determine the coating morphology, thickness, and infiltration of the porous
substrates. Wettability and SBF experiments were also carried out to investigate hydrophobicity and potential biofunctionality.
The results suggested how the porosity of the β-Ti alloy affects the mechanical characteristics and the
wettability of the substrate that was successfully infiltrated to exert an antimicrobial behavior
Applications and multidisciplinary perspective on 3D printing techniques: Recent developments and future trends
This is an open access article under the CC BY-NC-ND licensen industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in
3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D
printing techniques used for producing parts and components in three dimensions. The application of these
techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are
covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials.
This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions,
bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM)
applications. As a foundation for anticipated developments for TERM applications that could be useful for their
successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting
technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of
complex products and in the exploration of potential solutions to technological issues.Ministerio de Ciencia e Innovación PDC2022–133369- I00 PID2022–137911OB-I0
Applications and multidisciplinary perspective on 3D printing techniques: Recent developments and future trends
In industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study
Background and aims
Atherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics, as a high-throughput method, could provide helpful insights into the pathological mechanisms underlying atherosclerosis. In this study, we characterized the associations of plasma protein levels with CHD and with carotid intima-media thickness (CIMT), as a surrogate measure of atherosclerosis.
Methods
The discovery phase included 1000 participants from the KORA F4 study, whose plasma protein levels were quantified using the aptamer-based SOMAscan proteomics platform. We evaluated the associations of plasma protein levels with CHD using logistic regression, and with CIMT using linear regression. For both outcomes we applied two models: an age-sex adjusted model, and a model additionally adjusted for body mass index, smoking status, physical activity, diabetes status, hypertension status, low density lipoprotein, high density lipoprotein, and triglyceride levels (fully-adjusted model). The replication phase included a matched case-control sample from the independent KORA F3 study, using ELISA-based measurements of galectin-4. Pathway analysis was performed with nominally associated proteins (p-value < 0.05) from the fully-adjusted model.
Results
In the KORA F4 sample, after Bonferroni correction, we found CHD to be associated with five proteins using the age-sex adjusted model: galectin-4 (LGALS4), renin (REN), cathepsin H (CTSH), and coagulation factors X and Xa (F10). The fully-adjusted model yielded only the positive association of galectin-4 (OR = 1.58, 95% CI = 1.30–1.93), which was successfully replicated in the KORA F3 sample (OR = 1.40, 95% CI = 1.09–1.88). For CIMT, we found four proteins to be associated using the age-sex adjusted model namely: cytoplasmic protein NCK1 (NCK1), insulin-like growth factor-binding protein 2 (IGFBP2), growth hormone receptor (GHR), and GDNF family receptor alpha-1 (GFRA1). After assessing the fully-adjusted model, only NCK1 remained significant (β = 0.017, p-value = 1.39e-06). Upstream regulators of galectin-4 and NCK1 identified from pathway analysis were predicted to be involved in inflammation pathways.
Conclusions
Our proteome-wide association study identified galectin-4 to be associated with CHD and NCK1 to be associated with CIMT. Inflammatory pathways underlying the identified associations highlight the importance of inflammation in the development and progression of CHD
Findings and perspectives of β-Ti alloys with biomedical applications: Exploring beyond biomechanical and biofunctional behaviour
Early implant failure and bone resorption may occur in load-bearing conditions as a result of stress shielding brought on by a mismatch in the bone-Ti-implant modulus. A review with a novel multidisciplinary perspective is proposed in this work, which considers recent developments of β-Titanium alloys and new trends in novel microstructures, processing techniques, properties of dense and porous substrates, as well as the relationship between all these aspects and performance in service, in terms of improved its biomechanical and bio-functional balance. In addition to highlighting several modern and historical uses for Ti alloys, this review covers many cutting-edge novel β-Ti alloys and uses that promise to exceed historical standards. Also, it deepens through several important properties of these alloys, including toxicity of alloying elements, phase stability, thermo-mechanical processing, heat treatment, surface, and stress-induced modifications. The stiffness, hardness, fatigue and wear resistance, corrosion behaviour, biocompatibility, and manufacturing and surface modification effects on these parameters are also emphasized. In-vitro and in-vivo assays have been added to highlight important aspects of bioactivity and antibacterial behaviour, and future significant research areas are suggested along with new techniques to ensure the successful clinical application of β-Ti alloys
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