Chandra Observations of the Radio Galaxy 3C 445 and the Hotspot X-ray Emission Mechanism

We present new {\it Chandra} observations of the radio galaxy 3C 445, centered on its southern radio hotspot. Our observations detect X-ray emission displaced upstream and to the west of the radio-optical hotspot. Attempting to reproduce both the observed spectral energy distribution (SED) and the displacement, excludes all one zone models. Modeling of the radio-optical hotspot spectrum suggests that the electron distribution has a low energy cutoff or break approximately at the proton rest mass energy. The X-rays could be due to external Compton scattering of the cosmic microwave background (EC/CMB) coming from the fast (Lorentz factor $\Gamma\approx 4$) part of a decelerating flow, but this requires a small angle between the jet velocity and the observer's line of sight ($\theta\approx 14^{\circ}$). Alternatively, the X-ray emission can be synchrotron from a separate population of electrons. This last interpretation does not require the X-ray emission to be beamed.Comment: 9 pages, 5 figures, ApJ, in pres

Pre-primary education in Hong Kong : the evolution of governance and policy tools

published_or_final_versionPolitics and Public AdministrationMasterMaster of Public Administratio

Himali Didi: Finding the Strength in the Women of Nepal

The intent of this project is to bring to light the role of Nepalese women in adventure sports; a phenomenon that has existed in Nepal for the past few decades but has been widely unappreciated, if not unnoticed. In this study, women from various adventure companies in Nepal were interviewed to reveal the experiences and obstacles these women face in these occupations during their lifetimes. Some of them agreed to share their stories. Their journeys have taken them on (quite literal) climbs that have proven their physical strength and made tremendous moves to achieve gender equality in Nepal. Through this occupation, women not only gain the training and knowledge associated with outdoor sports, but in addition gain experiences, education, and finances that leads to further empowerment. These opportunities open doors in their lives that would have otherwise remained closed. Hopefully, the progress these women have made can be used as a model for female empowerment worldwide

Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years

Background: There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. Methods: A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. Primary outcome: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. Secondary outcomes: blind-rated parent–child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. Results: Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. Conclusions: Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent–child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials

A 6-month longitudinal study on numerical estimation in preschoolers

The current study investigated the development of numerical estimation in 3- to 5-year-old children sampled monthly for six months. At each session, children completed a task that assesses verbal number knowledge (Give-N task) and a numerical estimation task that assesses approximate number knowledge (Fast Cards). Results showed that children who acquired the cardinal principle (CP) during the course of the study showed marked improvement on the estimation task. Following CP acquisition, estimation became more accurate overall but also fluctuated widely. We discuss the implications of our findings for number word learning, particularly the mapping between verbal number and the approximate number system (ANS)

Pan-viral serology implicates enteroviruses in acute flaccid myelitis.

Since 2012, the United States of America has experienced a biennial spike in pediatric acute flaccid myelitis (AFM)1-6. Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely detected in cerebrospinal fluid (CSF)2. CSF from children with AFM (n = 42) and other pediatric neurologic disease controls (n = 58) were investigated for intrathecal antiviral antibodies, using a phage display library expressing 481,966 overlapping peptides derived from all known vertebrate and arboviruses (VirScan). Metagenomic next-generation sequencing (mNGS) of AFM CSF RNA (n = 20 cases) was also performed, both unbiased sequencing and with targeted enrichment for EVs. Using VirScan, the viral family significantly enriched by the CSF of AFM cases relative to controls was Picornaviridae, with the most enriched Picornaviridae peptides belonging to the genus Enterovirus (n = 29/42 cases versus 4/58 controls). EV VP1 ELISA confirmed this finding (n = 22/26 cases versus 7/50 controls). mNGS did not detect additional EV RNA. Despite rare detection of EV RNA, pan-viral serology frequently identified high levels of CSF EV-specific antibodies in AFM compared with controls, providing further evidence for a causal role of non-polio EVs in AFM

Diffusion in modified solid-state ionic conductors for energy applications: structure and dynamics

The poor ionic conductivity of candidate solid-state electrolytes in comparison to their liquid counterparts is a critical challenge in the implementation of all solid-state batteries. A strategy that has been widely used to address this issue is the modification of solid-state ionic conductors via chemical doping. However, the complex resultant structures and the presence of secondary phases have meant that understanding how the improved ionic conductivity is achieved remains a challenge. The work in this thesis presents a strategy to characterise the structure and develop an atomic level picture of the ionic diffusion processes in modified solid-state ionic conductors using a combination of powder diffraction and quasi-elastic neutron scattering (QENS). In doing so, this work aims to demonstrate a way to better understand the interplay between the structure of materials and ionic transport and thus facilitate the rational design and optimisation of solid-state ionic conductors for energy applications. The first part of this thesis focuses on NASICON (Na3Zr2Si2PO12), which is among the best performing known solid-state sodium ion conductors. Using neutron powder diffraction (NPD), we present a targeted study characterising the sodium sites to elucidate how fast ionic conduction is achieved in this material. A comparative NPD and preliminary QENS study on Mg-doped NASICON is also presented with the aim of identifying the primary Mg2+ doping site and how this affects sodium diffusion. The second part of this work presents a detailed characterisation of the structure and dynamics of γ-Na3PO4 which is present as a secondary phase in Mg-doped NASICON. As a rotor phase material, γ-Na3PO4 exhibits rotational diffusion of the phosphate units which influences sodium long-range diffusion. Hence, in the development of a model to describe sodium long-range diffusion, we present a strategy which may be extended to characterise ionic diffusion in similar systems where it is necessary to separate contributions from coupled diffusion processes

Elder academy : curriculum design and operation model = 長者學苑 : 課程設計與運作模式

Ever since the launching of the Elder Academy in 2007, numerous schools have joined the fray bringing with them valuable innovations, presenting the elderly and students with a wide variety of educational activities. The experiences of the Elder Academy at Lingnan and other academies are summarized in this handbook, in order to provide a frame of reference and an operation guide for other schools and organizations, so that they may design their own comprehensive teaching and learning plans. In this handbook, the roles and responsibilities of participating organizations are explained, and there are guidelines and suggestions regarding assessment methods. Apart from the instructions on teaching and learning activities, examples of course syllabi and activities are also included to offer some insights into the operation of the schools and their courses, allowing institutions to better carry out similar projects in a more systematic manner.https://commons.ln.edu.hk/osl_book/1001/thumbnail.jp

Do single-case experimental designs lead to randomised controlled trials of cognitive behavioural therapy interventions for adolescent anxiety and related disorders recommended in the National Institute of Clinical Excellence guidelines? A systematic review

BACKGROUND: Although Cognitive Behavioural Therapy (CBT) is effective for 60% of adolescents with anxiety disorders, only 36% are in remission post-intervention. This indicates that more effective treatments are needed which should be reflected in the NICE guidelines. We hypothesised that Single-case experimental designs (SCEDs) may provide a framework for accelerating the development of novel interventions. The primary purpose of this review was to investigate whether SCEDs are currently followed by randomised controlled trials (RCTs) of CBT intervention for adolescent anxiety disorders named in the NICE guidelines. The secondary objective was to investigate whether using SCEDs prior to RCTs could be a helpful approach. METHOD: For the primary search of SCEDs five databases were used (PsycINFO, PubMed, PsycArticles, Web of Science and ProQuest). Nineteen articles met eligibility criteria including a total of 107 participants. For the secondary search of RCTs named in the NICE guidelines for adolescent anxiety disorders 53 articles met inclusion criteria and were included in the systematic review. RESULTS: The 19 SCED studies included in the review were conducted with participants with a diverse range of anxiety disorders and across a range of CBT formats. Two of the SCEDs were followed by RCTs, but neither of these were named in the NICE guidelines for anxiety disorders. All of the SCEDs identified were rated as low quality with none meeting the criteria for the highest or second highest quality rating. From the secondary searches, none of the RCTs named in the NICE guide were preceded by SCEDs. CONCLUSIONS: It was concluded that currently SCEDs were not followed by RCTs of CBT interventions named in the NICE guidelines for adolescent anxiety disorders. However, it was suggested that SCEDs may provide an important framework for the development of more effective interventions for adolescents with anxiety