The Hegelian Inquiring System and Critical Triangulation Tools for the Internet Information Slave

This paper discusses informing, i.e. increasing people’s understanding of reality by providing representations of this reality. The Hegelian inquiry system is used to explain the nature of informing. Understanding the Hegelian inquiry system is essential for making informed decisions where the reality can be ambiguous and where sources of bias and manipulation have to be understood for increasing the level of free-informed choice. This inquiry system metaphorically identifies information masters and slaves, and we propose critical dialectic information triangulation (CDIT) tools for information slaves (i.e. non-experts) in dialect interactions with informative systems owned by supposed information masters. The paper concludes with suggestions for further research on informative triangulation tools for the internet and management information systems

Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells

Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression of human atherosclerosis. The expression of activin, its physiological inhibitor follistatin, and activin receptors were assayed in human vascular tissue specimens that repr

Measuring the usefulness of social media information for new venture development decision-making

Social media are being adopted by a growing number of entrepreneurs. Yet, the majority of academic research has focused on social media as marketing tools. Little is known on how these media are used by entrepreneurs for information acquisition and to what extent entrepreneurs use social media information in their decision-making during venture development. This paper addresses this gap in two ways. First, by assessing to what extent entrepreneurs perform four entrepreneurial information acquisition behaviors in social media environments: questioning, idea networking, observing and experimenting (Dyers et al., 2008). Second, by analyzing the extent to which entrepreneurs use social media information in their decision making for venture development

Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells

Conversion of one terminally differentiated cell type into another (or transdifferentiation) usually requires the forced expression of key transcription factors. We examined the plasticity of human insulin-producing β-cells in a model of islet cell aggregate formation. Here, we show that primary human β-cells can undergo a conversion into glucagon-producing α-cells without introduction of any genetic modification. The process occurs within days as revealed by lentivirus-mediated β-cell lineage tracing. Converted cells are indistinguishable from native α-cells based on ultrastructural morphology and maintain their α-cell phenotype after transplantation in vivo. Transition of β-cells into α-cells occurs after β-cell degranulation and is characterized by the presence of β-cell–specific transcription factors Pdx1 and Nkx6.1 in glucagon+ cells. Finally, we show that lentivirus-mediated knockdown of Arx, a determinant of the α-cell lineage, inhibits the conversion. Our findings reveal an unknown plasticity of human adult endocrine cells that can be modulated. This endocrine cell plasticity could have implications for islet development, (patho)physiology, and regeneration

A classification of social media methods of environmental scanning for entrepreneurial opportunity development

A limited amount of scholarly literature has focused on environmental scanning and the use of social media by nascent entrepreneurs. This paper aims to address these deficiencies in literature. A theoretical framework is presented that describes the level of scanning towards entrepreneurial opportunity development and includes fifteen social media based methods for scanning the environment with the objective of entrepreneurial opportunity development. This methods are reviewed on their data collection, interpretation and learning. Several implications for both practice and future research derive from this framework and are discussed

Revisiting QRS detection methodologies for portable, wearable, battery-operated, and wireless ECG systems

Cardiovascular diseases are the number one cause of death worldwide. Currently, portable battery-operated systems such as mobile phones with wireless ECG sensors have the potential to be used in continuous cardiac function assessment that can be easily integrated into daily life. These portable point-of-care diagnostic systems can therefore help unveil and treat cardiovascular diseases. The basis for ECG analysis is a robust detection of the prominent QRS complex, as well as other ECG signal characteristics. However, it is not clear from the literature which ECG analysis algorithms are suited for an implementation on a mobile device. We investigate current QRS detection algorithms based on three assessment criteria: 1) robustness to noise, 2) parameter choice, and 3) numerical efficiency, in order to target a universal fast-robust detector. Furthermore, existing QRS detection algorithms may provide an acceptable solution only on small segments of ECG signals, within a certain amplitude range, or amid particular types of arrhythmia and/or noise. These issues are discussed in the context of a comparison with the most conventional algorithms, followed by future recommendations for developing reliable QRS detection schemes suitable for implementation on battery-operated mobile devices.Mohamed Elgendi, Björn Eskofier, Socrates Dokos, Derek Abbot

ENCORT-CDW - Evaluation of the European recovery target for construction and demolition waste

The present EU target for recovery of construction and demolition waste does not promote sustainability. Interpretations of waste and recovery definitions rather than resource efficiency and safe handling affect the monitoring. The general weight-based target has to be altered to favour recycling of resource-rich materials, not only of high weight materials. High grade recycling should be distinguished and prioritized to ensure safe recovery. This requires improved knowledge on waste generation and handling as well as on emissions of dangerous substances. A common Nordic approach is advocated

Single and combined effects of αvβ3- and α5β1-integrins on capillary tube formation in a human fibrinous matrix

The fibrinous exudate of a wound or tumor stroma facilitates angiogenesis. We studied the involvement of RGD-binding integrins during tube formation in human plasma-derived fibrin clots and human purified fibrin matrices. Capillary-like tube formation by human microvascular endothelial cells in a 3D plasma-derived fibrinous matrix was induced by FGF-2 and TNF-α and depended largely on cell-bound u-PA and plasmin activities. While tube formation was minimally affected by the addition of either the αvβ3-integrin inhibiting mAb LM609 or the α5-integrin inhibiting mAb IIA1, the general RGD-antagonist echistatin completely inhibited this process. Remarkably, when αvβ3- and α5β1-integrins were inhibited simultaneously, tube formation was reduced by 78%. It was accompanied by a 44% reduction of u-PA antigen accumulation and 41% less production of fibrin degradation products. αvβ5-integrin-blocking antibodies further enhanced the inhibition by mAb LM609 and mAb IIA1 to 94%, but had no effect by themselves. αv-specific cRGD only inhibited angiogenesis when α5β1-integrin was simultaneously blocked. Endostatin mimicked the effect of α5β1-integrin and inhibited tube formation only in the presence of LM609 or cRGD (73 and 80%, respectively). Comparable results were obtained when purified fibrin matrices were used instead of the plasma-derived fibrinous matrices. These data show that blocking of tube formation in a fibrinous exudate requires the simultaneous inhibition of αvβ3- and α5β1-integrins. This may bear impact on attempts to influence angiogenesis in a fibrinous environment