What is the prognosis for patients with chronic urticaria?

The prognosis for chronic urticaria in primary care is unknown; studies in dermatology clinics in multiple countries report complete resolution in approximately one-third of patients with idiopathic chronic urticaria over 1 to 5 years and partial improvement in another third. Patients younger than 30 years with more severe symptoms, or symptoms with physical causes, fared less well (strength of recommendation: B, cohort studies)

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology

RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord

ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons. No meaningful therapies exist to slow ALS progression, and molecular insights into pathogenesis and progression are sorely needed. In that context, we used high-depth, next generation RNA sequencing (RNAseq, Illumina) to define gene network abnormalities in RNA samples depleted of rRNA and isolated from cervical spinal cord sections of 7 ALS and 8 CTL samples. We aligned \u3e50 million 2X150 bp paired-end sequences/sample to the hg19 human genome and applied three different algorithms (Cuffdiff2, DEseq2, EdgeR) for identification of differentially expressed genes (DEG’s). Ingenuity Pathways Analysis (IPA) and Weighted Gene Co-expression Network Analysis (WGCNA) identified inflammatory processes as significantly elevated in our ALS samples, with tumor necrosis factor (TNF) found to be a major pathway regulator (IPA) and TNFα-induced protein 2 (TNFAIP2) as a major network “hub” gene (WGCNA). Using the oPOSSUM algorithm, we analyzed transcription factors (TF) controlling expression of the nine DEG/hub genes in the ALS samples and identified TF’s involved in inflammation (NFkB, REL, NFkB1) and macrophage function (NR1H2::RXRA heterodimer). Transient expression in human iPSC-derived motor neurons of TNFAIP2 (also a DEG identified by all three algorithms) reduced cell viability and induced caspase 3/7 activation. Using high-density RNAseq, multiple algorithms for DEG identification, and an unsupervised gene co-expression network approach, we identified significant elevation of inflammatory processes in ALS spinal cord with TNF as a major regulatory molecule. Overexpression of the DEG TNFAIP2 in human motor neurons, the population most vulnerable to die in ALS, increased cell death and caspase 3/7 activation. We propose that therapies targeted to reduce inflammatory TNFα signaling may be helpful in ALS patients

PSVMC Nursing Reducing Anxiety With the Use of Aromatherapy Essential Oil Blends in Patients Awaiting Pre-scheduled Cesarean Section

https://digitalcommons.psjhealth.org/stvincent-bootcamp/1016/thumbnail.jp

Orbit structure and (reversing) symmetries of toral endomorphisms on rational lattices

We study various aspects of the dynamics induced by integer matrices on the invariant rational lattices of the torus in dimension 2 and greater. Firstly, we investigate the orbit structure when the toral endomorphism is not invertible on the lattice, characterising the pretails of eventually periodic orbits. Next we study the nature of the symmetries and reversing symmetries of toral automorphisms on a given lattice, which has particular relevance to (quantum) cat maps.Comment: 29 pages, 3 figure

Barcos arrastreros de merluza para el Perú

Hacer un estimado del tipo y tamaño más apropiado de arrastreras de merluza para ser operadas en Paita, el centro probable para el futuro desarrollo de la pesca de merluza en el Per

Performance studies of the CMS strip tracker before installation

Peer reviewe

A field inventory and collections summary of herpetofauna from the Sutter Buttes, an inland island within California\u27s Great Central Valley

The Sutter Buttes (Buttes) are a small, isolated mountain range in the Great Central Valley of California. Systematic study of the fauna and flora of this unique habitat has been limited by the private ownership of the entire mountain range. As a result, much of our knowledge about the herpetofauna of the Buttes is based on isolated observations and scattered museum records, most over 4 decades old. In this study, we present an updated inventory of the herpetofauna of the Buttes, based on a 2-year field survey within the boundaries of the first publicly protected property within the Buttes (Sutter Buttes State Park) and a comprehensive survey of museum specimens. The objective of this study was to develop a current herpetofaunal species list for the Buttes as a whole and the park specifically. We verify the occurrence of 16 previously identified herpetofaunal species within the park and provide evidence for 3 additional species. We also provide the first record of the widely invasive Pond Slider (Trachemys scripta); clarify the status of a previous misidentification of a federally threatened species, Giant Gartersnake (Thamnophis gigas); and provide evidence for the probable extirpation of 2 California Species of Special Concern, the Foothill Yellow-Legged Frog (Rana boylii) and Blainville’s Horned Lizard (Phrynosoma blainvillii). Therefore, our species list for the Buttes includes 20 herpetofaunal species. Museum specimens from the Buttes are located at 8 museums, with the majority at the California State University, Chico Vertebrate Museum. Sixteen of the 22 herpetofauna species extant or recently extirpated from the Buttes are represented by museum vouchers, with only 11 having tissue samples. This study sets an updated baseline for the further study and monitoring that will be required to facilitate effective management and conservation of the unique Sutter Buttes.Sutter Buttes (Buttes) es una pequeña y aislada cordillera montañosa en el Gran Valle Central de California. El estudio sistemático de la fauna y la flora de este hábitat único se ha visto limitado debido a que toda la cordillera es propiedad privada. Como resultado, gran parte del conocimiento de la herpetofauna de la cordillera se basa en observaciones aisladas y registros dispersos de museo, la mayoría con más de cuatro décadas de antigüedad. En este estudio, presentamos un inventario actualizado de la herpetofauna de la cordillera, basado en un estudio de campo de dos años dentro de los límites de la primera propiedad de protección pública en la zona (Sutter Buttes State Park) y en una exhaustiva investigación de especímenes de museo. El objetivo de este estudio fue crear un listado de especies de herpetofauna presentes actualmente en la zona en general y en el parque en específico. Verificamos 16 especies de herpetofauna, previamente identificadas, en el Parque y mostramos evidencia de tres especies adicionales en el Parque. También proporcionamos el primer registro de la tortuga invasora Jicotea de Estanque (Trachemys scripta), clarificamos el estado de un error de identificación previo de una especie, amenazada a nivel federal, la serpiente Jarretera Gigante (Thamnophis gigas), y aportamos pruebas de la probable extirpación de dos especies de interés especial para California, la Rana Patas Amarillas de las Estribaciónes (Rana boylii) y el Camaleón de Blainville (Phrynosoma blainvillii). Por lo tanto, nuestro listado de especies para la cordillera incluye 20 especies de herpetofauna. Los especímenes de museo de la cordillera se encuentran en ocho museos, la mayoría en Museo de Vertebrados de Chico en la Universidad Estatal de California. Dieciseis de las 22 especies de herpetofauna existentes, o recientemente extirpadas, de la cordillera están representadas por comprobantes de museo, sólo 11 de ellas con muestras de tejido. Este estudio establece una base actualizada para su estudio y seguimiento futuro que será necesario para facilitar la gestión y conservación de una zona única como Sutter Buttes