Using lexical chains for keyword extraction

Cataloged from PDF version of article.Keywords can be considered as condensed versions of documents and short forms of their summaries. In this paper, the problem of automatic extraction of keywords from documents is treated as a supervised learning task. A lexical chain holds a set of semantically related words of a text and it can be said that a lexical chain represents the semantic content of a portion of the text. Although lexical chains have been extensively used in text summarization, their usage for keyword extraction problem has not been fully investigated. In this paper, a keyword extraction technique that uses lexical chains is described, and encouraging results are obtained. (C) 2007 Elsevier Ltd. All rights reserved

Planetary migration in evolving planetesimals discs

In the current paper, we further improved the model for the migration of planets introduced in Del Popolo et al. (2001) and extended to time-dependent planetesimal accretion disks in Del Popolo and Eksi (2002). In the current study, the assumption of Del Popolo and Eksi (2002), that the surface density in planetesimals is proportional to that of gas, is released. In order to obtain the evolution of planetesimal density, we use a method developed in Stepinski and Valageas (1997) which is able to simultaneously follow the evolution of gas and solid particles for up to 10^7 yrs. Then, the disk model is coupled to migration model introduced in Del Popolo et al. (2001) in order to obtain the migration rate of the planet in the planetesimal. We find that the properties of solids known to exist in protoplanetary systems, together with reasonable density profiles for the disk, lead to a characteristic radius in the range 0.03-0.2 AU for the final semi-major axis of the giant planet.Comment: IJMP A in prin

Possible evolution of dim radio quiet neutron star 1E 1207.4-5209 based on a B-decay model

Dim radio-quiet neutron star (DRQNS) 1E 1207.4-5209 is one of the most heavily examined isolated neutron stars. Wide absorption lines were observed in its spectrum obtained by both XMM-Newton and Chandra X-ray satellites. These absorption lines can be interpreted as a principal frequency centered at 0.7 keV and its harmonics at 1.4, 2.1 and possibly 2.8 keV. The principal line can be formed by resonant proton cyclotron scattering leading to a magnetic field which is two orders of magnitude larger than the perpendicular component of the surface dipole magnetic field (B) found from the rotation period (P) and the time rate of change in the rotation period (\.{P}) of 1E 1207.4-5209. Besides, age of the supernova remnant (SNR) G296.5+10.0 which is physically connected to 1E 1207.4-5209 is two orders of magnitude smaller than the characteristic age ($\tau$=P/2\.{P}) of the neutron star. These huge differences between the magnetic field values and the ages can be explained based on a B-decay model. If the decay is assumed to be exponential, the characteristic decay time turns out to be several thousand years which is three orders of magnitude smaller than the characteristic decay time of radio pulsars represented in an earlier work. The lack of detection of radio emission from DRQNSs and the lack of point sources and pulsar wind nebulae in most of the observed SNRs can also be partly explained by such a very rapid exponential decay. The large difference between the characteristic decay times of DRQNSs and radio pulsars must be related to the differences in the magnetic fields, equation of states and masses of these isolated neutron stars.Comment: 13 pages, 1 figur

Nuclear Inelastic X-Ray Scattering of FeO to 48 GPa

The partial density of vibrational states has been measured for Fe in compressed FeO (w\"ustite) using nuclear resonant inelastic x-ray scattering. Substantial changes have been observed in the overall shape of the density of states close to the magnetic transiton around 20 GPa from the paramagnetic (low pressure) to the antiferromagnetic (high pressure) state. Our data indicate a substantial softening of the aggregate sound velocities far below the transition, starting between 5 and 10 GPa. This is consistent with recent radial x-ray diffraction measurements of the elastic constants in FeO. The results indicate that strong magnetoelastic coupling in FeO is the driving force behind the changes in the phonon spectrum of FeO.Comment: 4 pages, 4 figure

RXTE Studies of Long-Term X-ray Spectral Variations in 4U 1820-30

We present the results of detailed spectral studies of the ultra-compact low mass X-ray binary (LMXB) 4U 1820-30 carried out with the Rossi X-ray Timing Explorer (RXTE) during 1996-7. 4U 1820-30 is an ``atoll'' source X-ray burster (XRB) located in the globular cluster NGC 6624. It is known to have an 11 minute binary period and a ~176 day modulation in its 2--12 keV flux. Observations were made with the PCA and HEXTE instruments on RXTE at roughly one-month intervals to sample this long-term period and study flux-related spectral changes. There are clear correlations between our fitted spectral parameters and both the broad-band (2--50 keV) flux and the position in the color-color diagram, as described by the parameter S_a introduced by Mendez et al. (1999). In addition, we find a strong correlation between the position in the color-color diagram and the frequencies of the kilohertz quasi-periodic oscillations (kHz QPOs) reported by Zhang et al. (1998). This lends further support to the notion that evidence for the last stable orbit in the accretion disk of 4U 1820-30 has been observed. For a model consisting of Comptonization of cool photons by hot electrons plus an additional blackbody component, we report an abrupt change in the spectral parameters at the same accretion rate at which the kHz QPOs disappear. For a model consisting of a multicolor disk blackbody plus a cut-off power law, we find that the inner disk radius reaches a minimum at the same accretion rate at which the kHz QPO frequency saturates, as expected if the disk reaches the last stable orbit. Both models face theoretical and observational problems when interpreted physically for this system.Comment: 39 pages, 11 figures, accepted to the Astrophysical Journa

Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology

MAB21L1 loss of function causes a syndromic neurodevelopmental disorder with distinctive cerebellar, ocular, craniofacial and genital features (COFG syndrome).

BACKGROUND: Putative nucleotidyltransferase MAB21L1 is a member of an evolutionarily well-conserved family of the male abnormal 21 (MAB21)-like proteins. Little is known about the biochemical function of the protein; however, prior studies have shown essential roles for several aspects of embryonic development including the eye, midbrain, neural tube and reproductive organs. OBJECTIVE: A homozygous truncating variant in MAB21L1 has recently been described in a male affected by intellectual disability, scrotal agenesis, ophthalmological anomalies, cerebellar hypoplasia and facial dysmorphism. We employed a combination of exome sequencing and homozygosity mapping to identify the underlying genetic cause in subjects with similar phenotypic features descending from five unrelated consanguineous families. RESULTS: We identified four homozygous MAB21L1 loss of function variants (p.Glu281fs*20, p.Arg287Glufs*14 p.Tyr280* and p.Ser93Serfs*48) and one missense variant (p.Gln233Pro) in 10 affected individuals from 5 consanguineous families with a distinctive autosomal recessive neurodevelopmental syndrome. Cardinal features of this syndrome include a characteristic facial gestalt, corneal dystrophy, hairy nipples, underdeveloped labioscrotal folds and scrotum/scrotal agenesis as well as cerebellar hypoplasia with ataxia and variable microcephaly. CONCLUSION: This report defines an ultrarare but clinically recognisable Cerebello-Oculo-Facio-Genital syndrome associated with recessive MAB21L1 variants. Additionally, our findings further support the critical role of MAB21L1 in cerebellum, lens, genitalia and as craniofacial morphogenesis

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.

Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between drug responsiveness, tolerance and resistance, especially in the absence of preexisting subclones, remains unclear. In epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells, we demonstrate that residual disease and acquired resistance in response to EGFR inhibitors requires Aurora kinase A (AURKA) activity. Nongenetic resistance through the activation of AURKA by its coactivator TPX2 emerges in response to chronic EGFR inhibition where it mitigates drug-induced apoptosis. Aurora kinase inhibitors suppress this adaptive survival program, increasing the magnitude and duration of EGFR inhibitor response in preclinical models. Treatment-induced activation of AURKA is associated with resistance to EGFR inhibitors in vitro, in vivo and in most individuals with EGFR-mutant lung adenocarcinoma. These findings delineate a molecular path whereby drug resistance emerges from drug-tolerant cells and unveils a synthetic lethal strategy for enhancing responses to EGFR inhibitors by suppressing AURKA-driven residual disease and acquired resistance