Proceedings of the 13th annual conference of INEBRIA

CITATION: Watson, R., et al. 2016. Proceedings of the 13th annual conference of INEBRIA. Addiction Science & Clinical Practice, 11:13, doi:10.1186/s13722-016-0062-9.The original publication is available at https://ascpjournal.biomedcentral.comENGLISH SUMMARY : Meeting abstracts.https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-016-0062-9Publisher's versio

Streamlining clinical practice in an Australian community rehabilitation service using The Calderdale Framework

Background/Aims: With increased budgetary demands, pressure exists to create a flexible workforce and ensure efficient service delivery within health care services. This study investigated the impact of using The Calderdale Framework on team dynamics, client focus and communication, and resource use in an existing community rehabilitation service.Methods: The Calderdale Framework provided a structured process where clinicians were able to determine relevant tasks that could be shared with other health professionals to develop a streamlined transprofessional screening tool. Associated risks were reviewed and the resulting training and governance structures were embedded into practice. Staff views and resource usage costs were collected at three time points during the implementation process.Findings: Qualitative data from staff suggest a positive impact of The Calderdale Framework on team dynamics, understanding each other's roles, and client focus. Resource usage analysis revealed an increase in the number of client services provided, as well a reduction in cost per client appointment.Conclusions: This study provides further insight into the processes, resource usage outcomes and staff reflections of using The Calderdale Framework. This structured tool appears beneficial to develop a flexible workforce and an efficient service within this community rehabilitation context

Quantitative measures of FDG PET after neoadjuvant chemotherapy to predict breast cancer patient survival.

1088 Background: In patients with locally advanced breast cancer (LABC), qualitative FDG positivity following neo-adjuvant chemotherapy (NC) has been shown to be inversely associated with survival (Emmering, Annals Oncol, 2008). We investigated quantitative measures of post-therapy FDG uptake, namely standardized uptake value (SUV) and glycolytic flux (Ki), as predictors of breast cancer survival. Methods: Forty-seven patients with LABC underwent dynamic FDG PET scans close to or at the end of NC and prior to surgical resection. Post-therapy FDG uptake at the primary tumor site was measured by mean SUV from 45-60 minutes after FDG injection, maximum SUV (SUVmax) from 50-55 minutes, and FDG glycolytic flux (Ki). Pathologic response (PR) was assessed for at the time of surgical resection. Cox proportional hazards models were used to estimate associations between log-transformed measures of post-therapy FDG uptake, PR and outcome. Results: Median SUVmax was 1.9 (0.9 – 9.2) and median Ki was 2.2 (0.02 – 47.7) mL/min/g. Median follow-up for relapse was 5.7 years with 11 events and 6.3 years for survival with 10 deaths. PR was not significant for DFS (p = .39) or OS (p= .48). Post-therapy FDG uptake measures showed a statistically significant ability to predict survival. SUVmax predicted DFS (p=0.02) and OS (p=0.01). Ki was associated with DFS (p &lt;0.01) and OS (p &lt;0.01). PET measured hazard ratios were not attenuated in multivariate analysis controlling for known prognostic markers such as primary tumor PR and nodal status. However, multivariate survival models appeared highly influenced by one patient with the shortest survival time (1.3 years) and highest SUVmax and Ki. Without this patient, Ki remained a borderline independent predictor of DFS (p= .08) and OS (p= .07), but SUVmax was no longer significant for DFS (p= .32) or OS (p=0.26). Conclusions: Our analysis suggests that quantitative measures of post-therapy FDG PET provide information beyond PR for predicting which LABC patients are at highest risk for relapse and death. This information may be useful in directing post-surgery treatment. Supported by NIH grants CA42045, CA138293, and CA148131. </jats:p

Online supplement from Estrogen Receptor Binding (¹⁸F-FES PET) and Glycolytic Activity (¹⁸F-FDG PET) Predict Progression-Free Survival on Endocrine Therapy in Patients with ER⁺ Breast Cancer

Supplementary results Table S1. Agreement of predefined classifiers (n=90). Figure S1. Scatterplot of imaging parameter agreement. Figure S2. Association of clinical benefit (progression-free survival > 6 months on endocrine therapy) with quantitative imaging biomarkers predicting endocrine response, defined in Table 1. A. FES dynSUV B. FES SULmean3 C. FES/FDG ratio3. â-¬ is median, â-Š is mean. None are associated with PFS6 by logistic regression (N=76, Wald test p>0.10). Figure S3. Results of analysis using recursive partitioning to predict PFS by selected imaging parameters (FES SUVmax3, FES SULmax3, and FDG SUVmax3) Figure S4. Association of log(FDG SULmax) with reconstruction of the same scan by filtered back-projection (X axis) or ordered-subset expectation maximization (Y axis). Figure S5. Association FES SULmean with reconstruction of the same scan by filtered backprojection (X axis) or ordered-subset expectation maximization (Y axis) for 93 lesions in 16 patients from this study.</p

Factors Affecting the Efficiency of In Vitro Embryo Production in Prepubertal Mediterranean Water Buffalo

Embryos from prepubertal water buffalo can be produced using laparoscopic ovum pickup (LOPU) and in vitro embryo production (IVEP). However, to date, it is unclear what factors and environmental conditions can affect LOPU-IVEP efficiency in prepubertal animals, especially buffalo. In this study, we explored the impact of season, age and individual variation among female donor animals, as well as the effect of the sire used for in vitro fertilization. Donor animals between 2 and 6 months of age were stimulated using gonadotropins prior to LOPU, which was performed at two-week intervals. Following in vitro maturation and fertilization, the resulting embryos were then cultured to the blastocyst stage until they were either vitrified or transferred into recipient animals. The number of follicles available for aspiration and embryo development rates was stable throughout the year. As animals became older, there was a slight trend for fewer COCs recovered from LOPU and better embryo development. There was a large individual variation in both ovarian response and the developmental competence of oocytes among donors. The bull used for fertilization also had a significant impact on embryo development. Upon embryo transfer, pregnancy rates were not affected by the number of embryos transferred per recipient. The best pregnancy rates were achieved when transferring blastocysts, compared to compact morula or hatched blastocysts. Finally, vitrification had no effect on pregnancy rate compared to fresh embryos