Production of 21 Ne in depth-profiled olivine from a 54 Ma basalt sequence, Eastern Highlands (37° S), Australia

In this study we investigate the cosmogenic neon component in olivine samples from a vertical profile in order to quantify muogenic 21Ne production in this mineral. Samples were collected from an 11 m thick Eocene basalt profile in the Eastern Highlands of southeastern Australia. An eruption age of 54.15 ± 0.36 Ma (2σ) was determined from 40Ar/39Ar step-heating experiments (n = 6) on three whole-rock samples. A 36Cl profile on the section indicated an apparent steady state erosion rate of 4.7 ± 0.5 m Ma−1. The eruption age was used to calculate in situ produced radiogenic 4He and nucleogenic 3He and 21Ne concentrations in olivine. Olivine mineral separates (n = 4), extracted from the upper two metres of the studied profile, reveal cosmogenic 21Ne concentrations that attenuate exponentially with depth. However, olivine (Fo68) extracted from below 2 m does not contain discernible 21Ne aside from magmatic and nucleogenic components, with the exception of one sample that apparently contained equal proportions of nucleogenic and muogenic neon. Modelling results suggest a muogenic neon sea-level high-latitude production rate of 0.02 ± 0.04 to 0.9 ± 1.3 atoms g−1 a−1 (1σ), or <2.5% of spallogenic cosmogenic 21Ne production at Earth’s surface. These data support a key implicit assumption in the literature that accumulation of muogenic 21Ne in olivine in surface samples is likely to be negligible/minimal compared to spallogenic 21Ne

Improving Medication Adherence for Chronic Disease Using Integrated e-Technologies

Diabetes mellitus (DM) is a chronic disease affecting more than 285 people worldwide and the fourth leading cause of death. Increasing evidence suggests that many DM patients have poor adherence with prescribed medication therapies, impacting clinical outcomes. Patients' barriers to medication adherence and the extent to which barriers contribute to poor outcomes, however, are not routinely assessed. We designed a dashboard for an electronic health record system to integrate DM disease and medication data, including patient-reported barriers to adherence. Processes to support routine capture of data from patients are also being explored. The dashboard is being evaluated at multiple ambulatory clinics to examine whether integrated electronic tools can support patient-centered decision-making processes involving complex medication regimens for DM and other chronic diseases

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.

DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities. Because DAP12 has no extracelluar binding domains, it must pair with cell surface receptors for signal transduction. There are at least 15 known DAP12-associating cell surface receptors with distinct temporal and cell type-specific expression patterns. Our aim was to determine which receptors may be important in DAP12-associated bone pathologies. Here, we identify myeloid DAP12-associating lectin (MDL)-1 receptor (also known as CLEC5A) as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Activation of MDL-1 leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joint and promotes bone erosion. Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation. These findings suggest that MDL-1 receptor may be a therapeutic target for treatment of immune-mediated skeletal disorders

The Dilemma of Dezra: An Adolescent Manifesto in Five Parts

The adolescent body and the space of performance both employ a dynamic of liminality - constantly changing and shifting, never complete, never able to be fully defined, understood, or categorized. There is a compulsion we have in naming, categorizing and defining the bodies and emotional life of young people. Where the liminality of performance may be welcomed and viewed as a necessary and desired component of the experience, the liminality of adolescence is deeply troubling. The issue of erotic agency further complicates our relationship to the adolescent body - a concept of body that seems almost born out of erotic tension. The adolescent body is not yet seen as a sexual being, but is also not devoid of sexuality and erotic potential. We try so desperately to define and manage how an adolescent body might traverse its maturation and find its own erotic agency, and we strip them of that chance by managing it with such conviction. Through the course of developing my play, That One Forbidden Thing, which centers on a young girl who is experiencing her own, deeply complicated, sexual awakening, I encountered these dynamics in action - fixing themselves on my own work. I began to wonder if the tensions that were playing out on my play could shed light on how we might more productively engage adolescence - in performance, certainly, but also in life. This manifesto is a step towards finding a way to fully engage bodies that are limited in their access to agency and voice, a call-to-arms, of sorts, to push towards an existence wherein we might live fully and allow the experience of that living to be felt by any body that might want it

The Silent Problem: The Implicit Personhood Determination in State V. Montoya

Can a dead person still be considered a person under a criminal statute? This unspoken question is at the center of State v. Montoya, illustrating how a facially simple and uncontroversial case can actually be very misleading. On appeal in Montoya, the defendant argued that the conviction of robbery was unfounded, since the victim was already deceased at the time of theft. The Court of Appeals gave little attention to the argument about the victim’s personhood, instead analyzing the case through the lens of a rational link standard, essentially measuring the connection between a homicide and a subsequent robbery in determining whether those acts were sufficiently entwined and causally-related. This standard allowed the Court to circumvent a literal application of the State’s robbery statute, which requires the use of force sufficient to remove property from the immediate control of another person