“Better than we”: landscapes and materialities of race, class, and gender in pre-emancipation colonial Saba, Dutch Caribbean

This research strives to reveal how ideologies of race, class, and gender manifested in the the social, physical, and material landscapes of pre-emancipation colonial Saba, Dutch Caribbean. Race, class, and gender serve as facets and vectors for ideology. By viewing them as processes, their capacity to express such through their social and material environments inextricably tied to their particular temporal and spatial contexts. Through comparisons of the social and material environments of multiple, contemporaneous social contexts within Saba, common social and material vectors among these ideological facets can become apparent. In particular, this concerns: • How tensions between the “incomplete hegemony” of colonial authorities and plantation agriculture with Saban residents resulted in a dialectic between local landscapes, materiality, and ideologies of race, class, and gender. • Differentiating between slavery, free poverty, and low class in the archaeological record. • The dialectic between scale, locality, and perspective in defining and situating class and poverty

Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo

In this study, we determined the efficacy of various dosing regimens for erythromycin and azithromycin against four pneumococci with different susceptibilities to penicillin in an in vitro pharmacokinetic model and in a mouse peritonitis model. The MIC was 0.03 microg/ml, and the 50% effective doses (determined after one dose) of both drugs were comparable for the four pneumococcal strains and were in the range of 1.83 to 6.22 mg/kg. Dosing experiments with mice, using regimens for azithromycin of one to eight doses/6 h, showed the one-dose regimen to give the best result; of the pharmacodynamic parameters tested (the maximum drug concentration in serum [Cmax], the times that the drug concentration in serum remained above the MIC and above the concentration required for maximum killing, and the area under the concentration time curve), Cmax was the best predictor of outcome. The bacterial counts in mouse blood or peritoneal fluid during the first 24 h after challenge were not correlated to survival of the mice. The serum concentration profiles obtained with mice for the different dosing regimens were simulated in the in vitro pharmacokinetic model. Here as well, the one-dose regimen of azithromycin showed the best result. However, the killing curves in vivo in mouse blood and peritoneal fluid and in the vitro pharmacokinetic model were not similar. The in vitro killing curves showed a decrease of 2 log10 within 2 and 3 h for azithromycin and erythromycin, respectively whereas the in vivo killing curves showed a bacteriostatic effect for both drugs. It is concluded that the results in terms of predictive pharmacodynamic parameters are comparable for the in vitro and in vivo models and that high initial concentrations of azithromycin favor a good outcome

The Left-Right Dichotomy in Contemporary Democratic Theory

This thesis examines the phenomenon of Left-Right in political discourse from the perspective of political theories of radical democracy, discourse and representation. Extant research conceives of Left/Right as spatial metaphors, exploring their meaning and/or function in democratic politics. This thesis focuses on how Left-Right structure political identification in modernity and on the implications this has for theories and practices of radical democracy. The thesis argues that Left/Right structure political space and constitute public subjects who identify themselves and others in relation to that space. Through a critical discussion of Jürgen Habermas, it shows how such subjects are constituted as dispassionate individuals defined by their opinions, arguments and beliefs which acknowledge their partiality to others and the whole. Through a critical reading of Ernesto Laclau, the thesis also argues that radical democratic demands cannot be channelled through ‘the Left’, because doing so entails a confinement within the Left/Right space of politics, divesting subjects of political passion and commitment. This space co-opts disparate demands into participating in public debate as if they were not excluded, disabling them from laying claim to a radical equality that is not yet instantiated. Overall, the thesis aims to make a contribution to theories of radical democracy by showing that proponents of Laclauian populism should focus more on other spaces to effect a radical antagonism with the public subject and a dislocation of its relation to the state. Only this way can it reinstitute the truly radical dimensions of democracy that Left/Right tame

Consensus recommendations for the prevention of vomiting and nausea following high-emetic-risk chemotherapy

In this update of our 2005 document, we used an evidence-based approach whenever possible to formulate recommendations, emphasizing the results of controlled trials concerning the best use of antiemetic agents for the prevention of emesis and nausea following anticancer chemotherapies of high emetic risk. A three-drug combination of a 5-hydroxytryptamine type 3 receptor (5-HT(3)) receptor antagonist, dexamethasone, and aprepitant beginning before chemotherapy and continuing for up to 4 days remains the standard of care. We address issues of dose, schedule, and route of administration of five selective 5-HT(3) receptor antagonists. We conclude that, for each of these five drugs, there is a plateau in therapeutic efficacy above which further dose escalation does not improve outcome. In trials designed to prove the equivalence of palonosetron to ondansetron and granisetron, palonosetron proved superior in emesis prevention, while adverse effects were comparable. Furthermore, for all classes of antiemetic agents, a single dose is as effective as multiple doses or a continuous infusion. The oral route is as efficacious as the intravenous route of administration