Banking Customer Service Satisfaction

The concept of Banking Customer Service Satisfaction has attracted much attention in recent years. Organization that try to analyze this concept should begin with an understanding of various banking customer service satisfaction. Such models clarify various theories about customer satisfaction. Making research resources. This paper aims to develop a banking customer satisfaction model based on the factors which are the independent variables which are customer service, service quality, online banking and branch experience based on the expectancy and the confirmation model and to examine the Banking Customer Satisfaction which is the goal

Proapoptotic role of nuclear clusterin in brain

Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration

La clusterine (un nouveau régulateur de la voie NF- B et de la mort cellulaire)

La clusterine: un nouveau régulateur de la voie NF- B et de la mort cellulaire Plusieurs fonctions physiologiques ont été attribuées à la clusterine (CLU), dont le rôle important au cours de l'inflammation et de la tumorogenèse. Nous avons montré que CLU interagit avec I b-a phosphorylé et diminue la translocation de p50/p65. Nous avons aussi généré un ensemble de constructions " flaggées " pour les différentes isoformes de CLU. Les résultats de cette étude montrent que la régulation de la voie NF- B pourrait être restreinte à des séquences particulières de CLU. Nous avons développe une nouvelle approche de ciblage de CLU par la technique d' exon skipping qui permet d'induire préférentiellement la forme nucléaire épissée du gène très mal caractérisée. Nous avons montré que la surexpression de cette forme par cette stratégie induit la mort cellulaire.Clusterin: a new regulator of NF-kappaB pathway and cell death Clusterin is a multifunctional protein that plays numerous roles in mammalian cells. By mean of transcriptomic analysis, we previously demonstrated that lower expression of clu both in tissues and cultured fibroblast-like synoviocytes of rheumatoid arthritis patients compared to osteoarthritic patients. We showed that CLU interacts with phospho-IkB-a and decreases the translocation of p50/p65 to the nucleus. To specify the interaction sites of CLU with its partners and to study the CLU isoforms roles, we generated several molecular constructs coding for various CLU regions of interest and test their role on NF- B pathway and CLU subcellular localization. We have also developed a new approach of "exon skipping" in order to induce preferential expression of the nuclear spliced form of the gene. This strategy will allow a good understanding of nuclear forme poorly characterized.PARIS5-BU Méd.Cochin (751142101) / SudocSudocFranceF

Breeding Habitat Requirements of Bonelli’s Eagle and Trends in Eastern Morocco: Implications for Conservation Planning

The habitat requirements and biology of the nesting Bonelli’s Eagle (Aquila fasciata) in the Moulouya river gorges of southwestern Middle Atlas were studied from 2005–2015. Fifteen to fifty-eight Bonelli’s Eagle territories were occupied in one decade and produce in averaged 1.34 fledglings per occupied site. Population of Bonelli’s Eagles in the Moulouya river gorges seems healthy, though much of the apparent growth in population must be attributed to the increase in Houbara Buastard (Chlamydotis undata), Black-bellied Sandgrouse (Pterocles orientalis) and Barbary Partridge (Alectoris barbara) in an area of 80.000 km² near the study area were a conservation and hunting game reserve was established

Numerical computation of thermal performance of a simulation of a solar domestic hot water system

International audienc

Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death.

BACKGROUND: In prostate cancer the secreted form of clusterin (sCLU) has been described as an anti-apoptotic protein whose expression is increased after therapeutic intervention, whereas, the nuclear protein form nCLU was reported to have pro-apoptotic properties. METHODOLOGY: In order to provide new therapeutic approaches targeting CLU, we developed a strategy based on exon skipping by using a lentiviral construct to preferentially induce the nuclear spliced form of the protein. The molecular construct was transduced in LNCaP cells for testing the modulation of sensitivity of the transduced cells to pro-apoptotic stress. RESULTS AND CONCLUSIONS: We showed an increase of nCLU/sCLU expression ratio in the prostate cancer cell line "LNCaP" after lentiviral vector-U7 nCLU transduction. Moreover, we showed a significant inhibition of cell proliferation in nCLU-U7 LNCaP cells after treatment with cisplatin and after exposure to ionizing radiation compared to control cells. Finally, we showed that nCLU-U7 LNCaP cells exposure to UV-C significantly reduced an increase of cell death compared to control. Finally, we showed that modulating nCLU expression had profound impact on Ku70/Bax interaction as well as Rad17 expression which could be a key mechanism in sensitizing cells to cell death. In conclusion, this is the first report showing that increasing of nCLU/sCLU expression ratio by using an "on demand alternative splicing" strategy successfully increased sensitivity to radiotherapy and chemotherapy of prostate cancer cells

Increase sensitivity of LNCaP cells to irradiation following U7-nCLU LNCaP transduction.

<p>IR dose exposure effect at 48 hours on LNCaP cells proliferation. Data are expressed as % inhibition of the mean counts per minute (CPM) from 3 individual experiments. (*): P value <0.05 (Student’s t-test) vs control cells.</p

Increased UV-C induced death following U7-nCLU vector expression in LNCaP cells.

<p>FACS analysis was performed at 0, 2 and 4 hours after 10 min UV-C cell exposure. Cell death was assessed using propidium iodide (PI)/annexin V staining. The red rectangle surrounds PI−/Annexin V+cells. Histogram represent % of dead cells in each condition. Results are means +/− s.e.m. from 3 individual experiments. (*): P value <0.05 (Student’s t-test).</p