Emergentzietako pre-notifikazioaren eragina iktusaren tratamendu eta ondorioetan

[EUS] Azken urteotan tratamendu akutuaren aldetik iraultza garrantzitsua bizi izan duen prebalentzia handiko patologia da iktusa. Horrela, errekanalizaziorako tratamenduak erabili ahal izateko (beti ere emaitzak hobetzera bideratuta) denborak duen garrantzia ikusita, DUO-eko neurologia zerbitzuak Gipuzkoako emergentzia medikoko zerbitzuarekin adostuta, 2016.urteko ekainaren amaieran EPN jarri zuen martxan. EPN ezartzeaz geroztik bere erabilera zein izan den eta honek Gipuzkoa mailan iktusaren arreta denbora ezberdinetan izan duen eragina aztertu nahian planteatutako ikerketa da honako ha

Aplicación de la realidad aumentada para la asistencia en enseñanza médica

La telemedicina es una de las áreas que mejor aprovechan las nuevas tecnologías, permitiendo a pacientes contactar con médicos a miles de kilómetros de distancia, conectando cualquier lugar del planeta. Este servicio permite hoy en día conseguir un diagnóstico preciso, prescribir el tratamiento adecuado, estabilizar al paciente, decidir la necesidad de traslado y supervisar la evolución del paciente, todo esto sin tener que estar físicamente en la misma habitación. La idea original de este TFG era solventar un problema importante que tienen las unidades desplazadas fuera de nuestras fronteras. Este problema es que existe una gran dificultad en el correcto entendimiento entre cirujanos a distancia debido a las limitaciones de la cámara cenital con la que emiten las operaciones. Dicho problema surge porque en las misiones fuera del país lo habitual es enviar a especialistas en traumatología, que es la especialidad más demandada en conflictos donde suelen desplazarse nuestras tropas. De ahí que si surgen necesidades de cirugía de otro ámbito, podría ser muy útil este tipo de tecnologías. La idea original de poder mostrar la realidad aumentada sobre los cristales de las propias gafas es modificada porque el objetivo inicial era demasiado ambicioso, limitado por el hardware. Se pensó en empezar por algo más abarcable para continuar con la idea original si se avanzaba con el proyecto a tiempo. Así surge la necesidad de orientarlo hacia docencia. El objetivo final de este Trabajo Fin de Grado es la realización de una aplicación de realidad aumentada para ayudar en la docencia dentro de la unidad de telemedicina. Haciendo uso de unas gafas inteligentes, se busca conseguir enviar al hospital o a un aula lo mismo que ve el cirujano en tiempo real en el quirófano. A su vez se podrían proporcionar indicaciones sobre ese vídeo para los estudiantes que están presenciando la operación, con ello se conseguiría despejar el quirófano en las operaciones mas básicas, que son las que permiten alumnos alrededor y además poder ver las más delicadas pero sin perder la visión privilegiada que tiene el cirujano y la oportunidad de aprendizaje que tanto necesitan los futuros médicos

Beyond backscattering: Optical neuroimaging by BRAD

Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked up by the different modes of a FMF depending upon the angular scattering pattern, we obtain access to the directional scattering signatures of different tissues by decoupling illumination and detection paths. We exploit the distinct modal propagation properties of the FMF in concert with the long coherence lengths provided by modern wavelength-swept lasers to achieve multiplexing of the different modal responses into a combined OCT tomogram. We demonstrate BRAD sensing for distinguishing differently sized microparticles and showcase the performance of BRAD-OCT imaging with enhanced contrast for ex vivo tumorous tissue in glioblastoma and neuritic plaques in Alzheimer's disease

Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures

Our objective was to obtain new information on the in vitro antilymphocytic action of the cytokine synthesis inhibitor FK 506 and the purine biosynthesis inhibitors mycophenolic acid (MPA; the active moiety of RS61443) and mizoribine (MZB) when used alone or in combination. When added at the initiation of six-day human mixed lymphocyte cultures (MLC), FK 506, MPA or MZB exhibited dose-dependent inhibition of T-lymphocyte DNA synthesis. FK 506, however, was 100-fold more potent than MPA, and 10000-fold more potent than MZB. Combination of FK 506 with either MPA or MZB, each at suboptional concentrations, produced no more than additive inhibitory effects on 3H thymidine incorporation. Two-colour flow cytometric analysis of lymphocytes revealed that none of the drugs affected cell surface activation molecule expression (CD25 = IL-2R 55 kD α-chain, HLA-DR or CD71 = transferrin receptor [TR]) on allostimulated CD4+ or CD8+ cells harvested at three days of culture. By day six, however, all three agents, at levels which markedly inhibited proliferation, suppressed the expression of activation markers on both CD4+ and CD8+ cells. Also at day six, inhibition of activation molecule expression on CD4+ cells was achieved with the combination of FK 506 and either MPA or MZB at concentrations which, on their own, were ineffective. These data provide new, additional information on the in vitro antilymphocytic action of FK 506, MPA and MZB when used alone and in combination. © 1993

Case studies on digitization and metadata creation and management

Joint Master Degree in Digital Library Learning (DILL)This thesis’ initial aim is to study the life-cycle of metadata from its creation, its development and management and the role they play during digitization processes. Three memory institutions and their respective digitization projects are studied in order to know how they carry out the digital object production process, what is the life-cycle of metadata, by who, how and when are generated and to know what is the best way to generate and implement metadata in digitization projects. The research method is based on a qualitative approach and the research strategy is based in case studies. Data were collected with different techniques: documentation, questionnaires and semi-structured interviews. These questionnaires were sent to 3 key informants (one person for each institution) and subsequently interviews to the same informants were made in order to get deeper and more concrete information. The collected data suggest that most institutions do not have explicit guidelines but follow leading organizations’ standards. Because of the use of standards no institution had to cope with interoperability problems. Also in the opinion of respondents digitizing and creating metadata is not a remarkable challenge, they perceive it as another process among others. Considering the problems or challenges the informants stated to have, the emphasis can be put on budget. That is probably the aspect that most influences on the result, the institution with no budget limitations is the one that best and more complete metadata generates. Also budget has appeared to be a problem for preservation, and the institution with lower budget availability had to delegate the custody and management of its preservation copies to another institution

Combined use of Trichoderma and beneficial bacteria (mainly Bacillus and Pseudomonas): Development of microbial synergistic bio-inoculants in sustainable agriculture

Producción CientíficaAgriculture nowadays is facing many challenges, with among the most important to be able to feed the increasing human population through more sustainable and environmentally friendly production. In this context, the use of microorganisms has been extensively studied, both with fungi such as Trichoderma spp. and with bacteria, such as Bacillus spp. or Pseudomonas spp. While inoculation with these microorganisms has a positive effect on crops, their combination offers even greater potential as plant growth promoters and as biocontrol agents, with diverse mechanisms that are thoroughly considered in this review. Synergies between Trichoderma and bacteria cause more benefits than the sum of their parts, and this makes them a promising alternative for managing crops and controlling diseases or pests in modern agriculture. However, more studies are needed to determine the specific mechanisms of this synergistic effect in certain lines of research, since there is extensive data about their use as plant growth promoters or biocontrol agents against diseases and certain pests, but little or no information is available about their use against diseases caused by viruses or the effect on plant tolerance to abiotic stresses.Agencia Estatal de Investigación (industrial doctorate DIN2018-009852

La televisión escolar ante un gran futuro

Apenas ha cumplido los quince años la televisión escolar. Hacía tiempo ya que las posibilidades de conocer y ensanchar horizontes en la convivencia humana habían obtenido un seguro apoyo en los grandes medios de comunicación social, pero el más potente de todos, la televisión, no hizo su aparición en la escuela inmediatamente como medio para la enseñanza. Su entrada fue precedida por la adquisición de una serie de auxiliares audiovisuales, entre los que destaca la radio, que vinieron a sumarse a los tradicionales mapas geográficos, globos terráqueos, pizarra, etc., prácticamente el único material de este tipo a disposición de la escuela durante siglos

The Challenges for Implementing the Nagoya Protocol in a Multi-Level Governance Context:Lessons from the Belgian Case

The Nagoya Protocol on Access and Benefit-sharing is the latest protocol to the Convention on Biological Diversity (CBD). Its implementation can lead to two fundamentally different processes: a market-oriented self-regulatory approach, which emphasizes the self-regulating capacity of the economic actors involved, or a normative institutionalist approach, which focuses on the norms and formal rules of institutions that not only support and frame, but also shape and constrain the actions of the players acting within them. This paper analyzes the challenges related to the implementation of the Nagoya Protocol in the specific case of Belgium, and evaluates the possibility of moving from a self-regulatory to an institutional approach of implementation, which we argue is necessary to achieve the objectives of the Protocol. This move is analyzed in the specific multi-level governance context characterizing the Nagoya Protocol, which has a natural tendency towards a market-oriented self-regulatory approach

Emergentzietako pre-notifikazioaren eragina iktusaren tratamendu eta ondorioetan

[EUS] Azken urteotan tratamendu akutuaren aldetik iraultza garrantzitsua bizi izan duen prebalentzia handiko patologia da iktusa. Horrela, errekanalizaziorako tratamenduak erabili ahal izateko (beti ere emaitzak hobetzera bideratuta) denborak duen garrantzia ikusita, DUO-eko neurologia zerbitzuak Gipuzkoako emergentzia medikoko zerbitzuarekin adostuta, 2016.urteko ekainaren amaieran EPN jarri zuen martxan. EPN ezartzeaz geroztik bere erabilera zein izan den eta honek Gipuzkoa mailan iktusaren arreta denbora ezberdinetan izan duen eragina aztertu nahian planteatutako ikerketa da honako ha