Two nonlinear systems from mathematical physics

The dissertation is divided into two chapters. In the first one, we consider the 2-Vortex problem for two point vortices in a complex domain. The Hamiltonian of the system contains the regular part of a hydrodynamic Green’s function, the Robin function h and two coefficinets which are the strengths of the point vortices. We prove the existence of infinitely many periodic solutions with minimal period T which are a superposition of a slow motion of the center of vorticity along a level line of h and of a fast rotation of the two vortices around their center of vorticity. These vortices move in a prescribed subset of the domain that has to satisfy a geometric condition. The minimal period can be any T in a certain interval. Subsets to which our results apply can be found in any generic bounded domain. The proofs are based on a recent higher dimensional version of the Poincaré-Birkhoff theorem due to Fonda and Ureña. In the second part, we study bifurcations of a multi-component Schrödinger system. We construct a solution branch synchronized to a positive solution of a simpler system. From this branch, we find a sequence of local bifurcation values in the one dimensional case and also in the general case provided that the positive solution is nondegenerate

Cost-effectiveness of i-Sleep, a guided online CBT intervention, for patients with insomnia in general practice: protocol of a pragmatic randomized controlled trial.

BACKGROUND: Insomnia is a highly prevalent disorder causing clinically significant distress and impairment. Furthermore, insomnia is associated with high societal and individual costs. Although cognitive behavioural treatment for insomnia (CBT-I) is the preferred treatment, it is not used often. Offering CBT-I in an online format may increase access. Many studies have shown that online CBT for insomnia is effective. However, these studies have all been performed in general population samples recruited through media. This protocol article presents the design of a study aimed at establishing feasibility, effectiveness and cost-effectiveness of a guided online intervention (i-Sleep) for patients suffering from insomnia that seek help from their general practitioner as compared to care-as-usual. METHODS/DESIGN: In a pragmatic randomized controlled trial, adult patients with insomnia disorder recruited through general practices are randomized to a 5-session guided online treatment, which is called "i-Sleep", or to care-as-usual. Patients in the care-as-usual condition will be offered i-Sleep 6 months after inclusion. An ancillary clinician, known as the psychological well-being practitioner who works in the GP practice (PWP; in Dutch: POH-GGZ), will offer online support after every session. Our aim is to recruit one hundred and sixty patients. Questionnaires, a sleep diary and wrist actigraphy will be administered at baseline, post intervention (at 8 weeks), and at 6 months and 12 months follow-up. Effectiveness will be established using insomnia severity as the main outcome. Cost-effectiveness and cost-utility (using costs per quality adjusted life year (QALY) as outcome) will be conducted from a societal perspective. Secondary measures are: sleep diary, daytime consequences, fatigue, work and social adjustment, anxiety, alcohol use, depression and quality of life. DISCUSSION: The results of this trial will help establish whether online CBT-I is (cost-) effective and feasible in general practice as compared to care-as-usual. If it is, then quality of care might be increased because implementation of i-Sleep makes it easier to adhere to insomnia guidelines. Strengths and limitations are discussed. TRIAL REGISTRATION: Netherlands Trial register NTR 5202 (registered April 17(st) 2015)

A 1H NMR comparative study of human adult and fetal hemoglobins

AbstractThe affinities of the individual subunits in human adult and fetal hemoglobins to azide ion have been determined from the combined analysis of NMR and optical titration data. Structural and functional non-equivalence of the constituent subunits, i.e. α and β subunits in human adult hemoglobin and α and γ subunits in human fetal hemoglobin, has been confirmed. The function of the α subunits, which are common to both hemoglobins, is essentially identical in these hemoglobins and, in spite of the substitutions of 39 amino acid residues between β and γ subunits, they exhibit similar azide ion affinities. The present study also demonstrates that the NMR spectral comparison between the two proteins provides signal assignments to the individual subunits in intact tetramer

Sleep spindle and slow wave frequency reflect motor skill performance in primary school-age children

Background and Aim: The role of sleep in the enhancement of motor skills has been studied extensively in adults. We aimed to determine involvement of sleep and characteristics of spindles and slow waves in a motor skill in children. Hypothesis: We hypothesized sleep-dependence of skill enhancement and an association of interindividual differences in skill and sleep characteristics. Methods:: 30 children (19 females, 10.7 ± 0.8 years of age; mean ± SD) performed finger sequence tapping tasks in a repeated-measures design spanning 4 days including 1 polysomnography (PSG) night. Initial and delayed performance were assessed over 12 h of wake; 12 h with sleep; and 24 h with wake and sleep. For the 12 h with sleep, children were assigned to one of three conditions: modulation of slow waves and spindles was attempted using acoustic perturbation, and compared to yoked and no-sound control conditions. Analyses: Mixed effect regression models evaluated the association of sleep, its macrostructure and spindles and slow wave parameters with initial and delayed speed and accuracy. Results and Conclusions: Children enhance their accuracy only over an interval with sleep. Unlike previously reported in adults, children enhance their speed independent of sleep, a capacity that may to be lost in adulthood. Individual differences in the dominant frequency of spindles and slow waves were predictive for performance: children performed better if they had less slow spindles, more fast spindles and faster slow waves. On the other hand, overnight enhancement of accuracy was most pronounced in children with more slow spindles and slower slow waves, i.e., the ones with an initial lower performance. Associations of spindle and slow wave characteristics with initial performance may confound interpretation of their involvement in overnight enhancement. Slower frequencies of characteristic sleep events may mark slower learning and immaturity of networks involved in motor skills

Licenciamento ambiental : herói, vilão ou vítima?

- Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à lei de Direitos Autorais, não disponibilizamos a obra na íntegra.- Localização na estante: 34:504(81) L698

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

PEMBINAAN TANGGUNG JAWAB SOSIAL SISWA MELALUI PENDIDIKAN UMUM :Studi Kualitatif disuatu Sekolah Menengah Atas Negeri Subang

Pendidikan Nasional Indonesia bertujuan untuk mengembangkan potensi peserta didik agar menjadi manusia yang beriman, bertaqwa kepada fuhan YME. berahlak mulia, sehat, berilmu, cakap, kreatif, niandiri dan menjadi warga yang demokratis serta bertanggung jawab. Pada pendidikan formal" tujuan tersebut dilaksanakan melalui program sekolah berupa mata pelajaran yang berfimesi sebagai pendidikan umum, pendidikan ketcrampilan dan pendidikan akademik. ~ Pelaksanaan pendidikan umum di sekolah merupakan masalah pokok dalam penelitian ini. Bertujuan mendapatkan gambaran yang jelas tentang tanggung jawab sosial siswa di SMA dan juga SMP, pelaksamaan pembinaan tanggung jawab sosial siswa melalui pendidikan umum dan faktor yang mempengaruhi keberhasilan pembinaan tersebut. Hasil penelitian ini diharapkan dapat bermanfaat bagi guru terutama dalam melaksanakan tugasnya yang utama yaitu mengembangkan keseimbangan nengetahuan teoritis dan praktis serta nilai-nilai dalam peningkatan kualitas siswa di sekolah, juga bagi orang tua sebagai pendidik dalam keluarga sebagai upaya menunjang proses pembinaan tanggung jawab sosial anak. Penelitian ini menggunakan pendekatan kualitatif, bemsaha mengungkap pelaksanaan tanggung jawab sosial siswa melalui pendidikan umum. Data dikumpulkan melalui teknik observasi, wavvancara dan studi dokumentasi. Dari hasil penelitian terungkap baliwa pelaksanaan pendidikan umum di sekolali mampu membina tanggung jawab siswa, walaupun hasilnya banyak dipengaruhi oleh nengalaman belajar siswa sebclumnya. Faktor yang mempengaruhi pembinaan selain sekolah adalah orang tua dan masyarakat. Kerjasama yang baik diantara tripusat pendidikan akan memperbesar keberhasilan upaya yang dilakukan gum di sekolah. Dalam penelitian ini ditemukan beberapa masalah yaitu masih perlunya ditingkatkan kerjasama antara sekolah dan orang tua dalam upaya pembinaan tanggung jawab sosial siswa dan masih adanya sebagian kecil siswa yang merasa terpaksa mantaati berbagai peraturan di sekolah serta masalah yang berkaitan dengan kctcrbatasan waktu dan tcnaga gum yang menyebabkan kurang maksunalnya upaya pemantauan terhadap siswa di luar sekolah. Temuan makna pada penelitian ini adalah keteladanan kepala sekolah, gum dan orang tua memiliki pengamh besar terhadap pembinaan tanggung jawab sosial siswa. Kerjasama yang baik diantara para gum. kesadaran siswa. kebiasaan dan pola hidup disiplin dalam keluarga memberi sumbangan besar terhadap keberhasilan upaya yang dilakukan. Penelitian ini merekomendasikan bahwa kemampuan guru dalam proses belajar mcngajar (PBM) kluisusnya mata pelajaran umum harus ditingkatkan melalui pelatihan-nelatihan, kemauan clan inisiatif guru dalam pengembangan kemampuan mengajar merupakan kunci pokoknya. Kerjasama antara orang tua, sekolah dan masyarakat periu ditingkatkan melalui wadah yang telali tersedia vaitu dewan sekolah

Insomnia Really Hurts: Effect of a Bad Night's Sleep on Pain Increases With Insomnia Severity

Insomnia and chronic pain are highly prevalent conditions and are often comorbid. Somatic complaints other than pain are also often observed in insomnia. Poor sleep and pain are known to mutually reinforce each other. However, it is unknown whether the habitual severity of insomnia modulates the acute effect of a particularly bad night's sleep on the next day's pain severity, and whether it modulates the acute effect of pain on the following night's sleep quality. Using data from 3,508 volunteers (2,684 female, mean age 50.09 y), we addressed these questions in addition to the associations between the habitual severity of insomnia, somatic complaints, and pain. Results indicated that people suffering from more severe habitual insomnia showed stronger mutual acute within-day reactivity of pain and poor sleep quality. The same increased reactivity was found in people with more severe habitual pain. Interestingly, the acute within-day mutual reactivity of pain and sleep quality showed consistent asymmetry. Pain worsened more after a particularly bad night's sleep than it improved after a particularly good night's sleep. Likewise, sleep worsened more after a day with more-than-usual pain than it improved after a day with less-than-usual pain. Future interventions may profit from addressing this asymmetric mutual reactivity especially in people with severe comorbid insomnia and chronic pain

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesPersistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint analysis with an independent sample (n = 7,565). Our top association (MEIS1, P < 5 × 10-8) has previously been implicated in restless legs syndrome (RLS). Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. Sex-specific analyses suggest that there are different genetic architectures between the sexes in addition to shared genetic factors. We show substantial positive genetic correlation of insomnia complaints with internalizing personality traits and metabolic traits and negative correlation with subjective well-being and educational attainment. These findings provide new insight into the genetic architecture of insomnia.Netherlands Organization for Scientific Research NWO Brain & Cognition 433-09-228 European Research Council ERC-ADG-2014-671084 INSOMNIA Netherlands Scientific Organization (NWO) VU University (Amsterdam, the Netherlands) Dutch Brain Foundation Helmholtz Zentrum Munchen - German Federal Ministry of Education and Research state of Bavaria German Migraine & Headache Society (DMKG) Almirall AstraZeneca Berlin Chemie Boehringer Boots Health Care GlaxoSmithKline Janssen Cilag McNeil Pharma MSD Sharp Dohme Pfizer Institute of Epidemiology and Social Medicine at the University of Munster German Ministry of Education and Research (BMBF) German Restless Legs Patient Organisation (RLS Deutsche Restless Legs Vereinigung) Swiss RLS Patient Association (Schweizerische Restless Legs Selbsthilfegruppe