A within farm clinical trial to compare two treatments (parenteral antibacterials and hoof trimming) for sheep lame with footrot

From observational studies, farmers who use parenteral antibacterials to promptly treat all sheep with footrot (FR) or interdigital dermatitis (ID) have a prevalence of lameness of <2% compared with a prevalence of 9% lameness reported by farmers who treat lame sheep by trimming affected feet. We tested the hypothesis that prompt treatment of sheep lame with naturally developing FR or ID with parenteral and topical antibacterials reduces the prevalence and incidence of lameness with these conditions compared with less frequent treatment with trimming of hoof horn and applying topical antibacterials. A further hypothesis was that reduction of ID and FR would improve productivity. A lowland sheep flock with 700 ewes was used to test these hypotheses in an 18-month within farm clinical trial with four groups of ewes: two intervention and two control. The duration and severity of lameness was used to categorise sheep into three weighted scores of lameness (WLS): never lame (WLS0), mildly lame/lame for <6 days (WLS1) and severely or chronically lame (WLS2). The intervention reduced the prevalence of lameness due to FR and ID in ewes and lambs and the incidence of lameness in ewes. The WLS was also significantly lower in sheep in the intervention groups. Ewes with a higher WLS were subsequently significantly more likely to have a body condition score <2.5 and to have lame lambs. Significantly more ewes lambed and successfully reared more lambs that were ready for slaughter at a younger age in the intervention versus control groups. There was an increase in the gross margin of £630/100 ewes mated in the intervention group, including the cost of treatment of £150/100 ewes mated. We conclude that prompt parenteral and topical antibacterial treatment of sheep lame with ID and FR reduced the prevalence and incidence of these infectious conditions and led to improved health, welfare and productivity

Alien Registration- Green, Everett (Madison, Somerset County)

https://digitalmaine.com/alien_docs/6581/thumbnail.jp

Infrared Variability of Two Dusty White Dwarfs

The most heavily polluted white dwarfs often show excess infrared radiation from circumstellar dust disks, which are modeled as a result of tidal disruption of extrasolar minor planets. Interaction of dust, gas, and disintegrating objects can all contribute to the dynamical evolution of these dust disks. Here, we report on two infrared variable dusty white dwarfs, SDSS J1228+1040 and G29-38. For SDSS J1228+1040, compared to the first measurements in 2007, the IRAC [3.6] and [4.5] fluxes decreased by 20% by 2014 to a level also seen in the recent 2018 observations. For G29-38, the infrared flux of the 10 $\mu$m silicate emission feature became 10% stronger between 2004 and 2007, We explore several scenarios that could account for these changes, including tidal disruption events, perturbation from a companion, and runaway accretion. No satisfactory causes are found for the flux drop in SDSS J1228+1040 due to the limited time coverage. Continuous tidal disruption of small planetesimals could increase the mass of small grains and concurrently change the strength of the 10 $\mu$m feature of G29-38. Dust disks around white dwarfs are actively evolving and we speculate that there could be different mechanisms responsible for the temporal changes of these disks.Comment: ApJ, in pres

Investigations in pyrrol chemistry ..

Typewritten sheets in cover. Thesis (M.A.)--Boston University Bibliography: p. 22

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones

The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the regulatory major immediate-early protein, interacts with DNA and dissociates at salt concentrations between 0.3 and 0.6 M NaCl. pp76, a cleavage product of pp89, and additional minor ie1 proteins eluted already at low ionic strength. Cellular DNA-binding factors were required for association of pp89 with DNA. These factors were identified as core histones. Chromatography of IE proteins on histone-Sepharose in the absence of DNA revealed a high-binding affinity that was resistant to 2 M NaCl. These results suggest that pp89 has no direct DNA-binding activity. A role for an amino acid sequence homology in the N-terminal region of pp89 with histone H2B in the pp89-histone-DNA Interaction is discussed

On the Resolution of Time Problem in Quantum Gravity Induced from Unconstrained Membranes

The relativistic theory of unconstrained $p$-dimensional membranes ($p$-branes) is further developed and then applied to the embedding model of induced gravity. Space-time is considered as a 4-dimensional unconstrained membrane evolving in an $N$-dimensional embedding space. The parameter of evolution or the evolution time $\tau$ is a distinct concept from the coordinate time $t = x^0$. Quantization of the theory is also discussed. A covariant functional Schr\" odinger equations has a solution for the wave functional such that it is sharply localized in a certain subspace $P$ of space-time, and much less sharply localized (though still localized) outside $P$. With the passage of evolution the region $P$ moves forward in space-time. Such a solution we interpret as incorporating two seemingly contradictory observations: (i) experiments clearly indicate that space-time is a continuum in which events are existing; (ii) not the whole 4-dimensional space-time, but only a 3-dimensional section which moves forward in time is accessible to our immediate experience. The notorious problem of time is thus resolved in our approach to quantum gravity. Finally we include sources into our unconstrained embedding model. Possible sources are unconstrained worldlines which are free from the well known problem concerning the Maxwell fields generated by charged unconstrained point particles.Comment: 22 Page

The Young Pioneers or With La Salle on the Mississippi

https://commons.und.edu/settler-literature/1013/thumbnail.jp

A quantum weak energy inequality for the Dirac field in two-dimensional flat spacetime

Fewster and Mistry have given an explicit, non-optimal quantum weak energy inequality that constrains the smeared energy density of Dirac fields in Minkowski spacetime. Here, their argument is adapted to the case of flat, two-dimensional spacetime. The non-optimal bound thereby obtained has the same order of magnitude, in the limit of zero mass, as the optimal bound of Vollick. In contrast with Vollick's bound, the bound presented here holds for all (non-negative) values of the field mass.Comment: Version published in Classical and Quantum Gravity. 7 pages, 1 figur

Investigations in pyrrol chemistry ..

Typewritten sheets in cover. Thesis (M.A.)--Boston University Bibliography: p. 22